1000 resultados para saint wolf poetry Milton
Resumo:
Imprimés et manuscrits. — On y remarque des lettres originales de Mauduyt (fol. 122, etc.), de P. Guérin de Tenein, archevêque d'Embrun (fol. 139), de Noüet (fol. 145 et 186), du duc de Luynes (fol. 163 et 167) et du duc de Villeroy (fol. 175). — Il y a une table des pièces en tète du volume.
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Une table alphabétique termine le volume.
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Manuscrit autographe.
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Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated response to various signals received from many organs, which depends heavily on the integrity and physiological status of the adipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma), which is a fatty acid- and eicosanoid-dependent nuclear receptor that plays key roles in the development and maintenance of the adipose tissue. Furthermore, synthetic PPARgamma agonists are therapeutic agents used in the treatment of type 2 diabetes.This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles of PPARgamma in this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits of targeting this nuclear receptor with still-to-be-identified highly selective PPARgamma modulators.
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Collection : [Physiologies Aubert]
Resumo:
Collection : [Physiologies Aubert]
