Report on activities of the Caribbean Council for Science and Technology: Workshop on Methodology for Assessment of National Science and Technology Capabilities

Informe de la reunion sobre metodologia para la evaluacion de las capacidades nacionales en ciencia y tecnologia, realizada en Suriname, del 12 al 15 de octubre de 1981. Presenta un resumen de los debates, conclusiones y recomendaciones.

Informe de actividades del Consejo del Caribe de Ciencia y Tecnología (CCCT), 1981-1982 = Report of the activities of the Caribbean Council for Science and Technology (CCST), 1981-1982

Describe las actividades realizadas por el Consejo del Caribe para la Ciencia y la Tecnologia, desde noviembre de 1981 a diciembre de 1982. Incluye el informe de la segunda reunion plenaria del Consejo, llevada a cabo en Kingston, Jamaica, del 3 al 5 de noviembre de 1982.

A brief overview of economic activities of Caribbean countries, 1988

Includes bibliography

Report to the Caribbean Development and Co-operation Committee (CDCC) on activities of the Caribbean Council for Science and Technology (CCST) for the period 1984-1990

Describe los objetivos del CCCT, su programa de trabajo, proyectos, y actividades realizadas entre 1984 y 1990.

Synthesis, characterization, x-ray structure, DNA cleavage, and cytotoxic activities of palladium(ii) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphane

Complexes of the type [PdX(PPh3)(1)]X [1 = 4-phenyl-3- thiosemicarbazide; X = Cl- (2), Br- (3), I- (4), and SCN- (5)] have been synthesized and characterized by elemental analyses and IR, UV/Vis, and 1H and 13C NMR spectroscopy. The molecular structure of complex 4 was determined by single-crystal X-ray diffraction. The binding of the complexes with a purine base (guanosine) was investigated by 1H NMR spectroscopy and mass spectrometry, which showed the complexes to coordinate to guanosine through N7. A gel electrophoresis assay demonstrated the ability of 2-5 to cleave DNA plasmid. All the complexes were tested in vitro by means of the MTT assay for their cytotoxicity against two murine cell lines, LM3 (mammary adenocarcinoma) and LP07 (lung adenocarcinoma), and compared with cisplatin. Complexes 2-5 exhibited good cytotoxicity that surpasses that of cisplatin in the case of LM3. A series of thiosemicarbazide/phosphane palladium(II) complexes have been synthesized and fully characterized. These complexes are able to cleave DNA plasmid and show cytotoxicity against adenocarcinoma (mammary LM3 and lung LP07), surpassing the cytotoxicity of cisplatin in the case of LM3. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Report on activities of the Caribbean Council for Science and Technology

Informe de la Primera Sesión Plenaria del Consejo del Caribe para Ciencia y Tecnología y subsiguientes actividades en la implementación de las decisiones del Consejo. Contiene guías para el programa de trabajo (1981-1983).

Information activities of the Latin American Demographic Centre (ECLAC

Includes bibliography

Description of information activities of the Caribbean Documentation Centre

Analiza la información utilizada y generada por las unidades de información bibliográfica y los bancos de datos del Centro de Documentación del Caribe; su papel como coordinador regional del CARISPLAN; y presenta las actividades y una lista de publicaciones producidas por la Unidad de Población.

Estrogenic and mutagenic activities of crotalaria pallida measured by recombinant yeast assay and ames test

Background: Crotalaria pallida Ailton is a plant belonging to the Fabaceae family, popularly known as rattle or rattlesnake and used in traditional medicine to treat swelling of the joints and as a vermifuge. Previous pharmacological studies have also reported anti-inflammatory, antimicrobial and antifungal activities. Nevertheless, scientific information regarding this species is scarce, and there are no reports related to its possible estrogenic and mutagenic effects. Thus, the purpose of the present study was to investigate the estrogenic potential of C. pallida leaves by means of the Recombinant Yeast Assay (RYA), seeking an alternative for estrogen replacement therapy during menopause; and to reflect on the safe use of natural products to assess the mutagenic activity of the crude extract from C. pallida leaves, the dichloromethane fraction and stigmasterol by means of the Ames test.Methods: The recombinant yeast assay with the strain BY4741 of Saccharomyces cerevisiae, was performed with the ethanolic extract, dichloromethane fraction and stigmasterol isolated from the leaves of C. pallida. Mutagenic activity was evaluated by the Salmonella/microsome assay (Ames test), using the Salmonella typhimurium tester strains TA100, TA98, TA97 and TA102, with (+S9) and without (-S9) metabolization, by the preincubation method.Results: All samples showed estrogenic activity, mainly stigmasterol. The ethanolic extract from C. pallida leaves showed mutagenic activity in the TA98 strain (-S9), whereas dichloromethane fraction and stigmasterol were found devoid of activity.Conclusion: Considering the excellent estrogenic activity performed by stigmasterol in the RYA associated with the absence of mutagenic activity when evaluated by the Ames test, stigmasterol becomes a strong candidate to be used in hormone replacement therapy during menopause. © 2013 Boldrin et al.; licensee BioMed Central Ltd.

Synthesis, crystal structures, antimicrobial, antifungal and antituberculosis activities of mixed ligand silver(I) complexes

The biological activity of some new mixed silver-phosphane-thio-ligand complexes, with 1:1:2, 1:1:1 and 1:2:1 (Ag:phospine:ligand) compositions, have been examined. Ten compounds were prepared using a series of silver(I) salts [AgX, where X = NO3, ClO4, PF6 and Br], tertiary phosphines and the ligands thi-osemicarbazide, 2-(propan-2-ylidene) hydrazinecarbothioamide, and thiazolidine-2-thione. The syntheses were carried out under ambient conditions, and the ten complexes obtained were found to be light stable. All 10 compounds were characterized by elemental analysis, FTIR, and NMR spectroscopy, whereas nine compounds were characterized by X-ray diffraction analysis. The anti-proliferative activities were evaluated by minimum inhibitory concentration (MIC: lg/mL) in an aqueous suspension system and they all show promising potential activity against selective strains of Gram-positive and Gram-negative bacteria, fungous and Mycrobaterium tuberculosis H37Rv. © 2013 Elsevier Ltd. All rights reserved.

Actividades de los gobiernos de América Latina y el Caribe para la superación de la pobreza = Anti-poverty activities of the governments of Latin America and the Caribbean

Incluye Bibliografía