L'Univers

1871/10/20 (Numéro 1588).

L'Univers

1871/08/21 (Numéro 1528).

S. Maria Antiqua, S. Maria Rotonda, Moserato, Santa, S. Martino, Buchima, Dominica

Julkaisussa: Libro di Benedetto Bordone nel qual si ragiona de tutte l'isole del mondo

Caloiero

Julkaisussa: Libro di Benedetto Bordone nel qual si ragiona de tutte l'isole del mondo

Europa

Julkaisussa: Libro di Benedetto Bordone nel qual si ragiona de tutte l'isole del mondo

Santa Madera, Camera di Lioni, Fonzal, monerico

Julkaisussa: Libro di Benedetto Bordone nel qual si ragiona de tutte l'isole del mondo

Jamaiqua, Spagnola, Chanchite, Curtana, Maria Tambal, Paria

Julkaisussa: Libro di Benedetto Bordone nel qual si ragiona de tutte l'isole del mondo

[Il mondo]

Julkaisussa: Libro di Benedetto Bordone nel qual si ragiona de tutte l'isole del mondo

Opera di M. Giacomo Gastaldi Piamontese cosmografo in Venetia disegno, particolare de regni e regioni, che son da Venetia, a Constantinopoli, et da Constantinopoli, a Vienna, d'Austria et da Vienna ..

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Opera di M. Giacomo Gastaldi Piamontese cosmografo in Venetia disegno, particolare de regni e regioni, che son da Venetia, a Constantinopoli, et da Constantinopoli, a Vienna, d'Austria et da Vienna ..

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Multiple facets of HIV-associated renal disease

HIV infection has a broad spectrum of renal manifestations. This study examined the clinical and histological manifestations of HIV-associated renal disease, and predictors of renal outcomes. Sixty-one (64% male, mean age 45 years) HIV patients were retrospectively evaluated. Clinical presentation and renal histopathology were assessed, as well as CD4 T-cell count and viral load. The predictive value of histological lesion, baseline CD4 cell count and viral load for end-stage renal disease (ESRD) or death were determined using the Cox regression model. The outcomes of chronic kidney disease (CKD) and ESRD or death were evaluated by baseline CD4 cell count. The percent distribution at initial clinical presentation was non-nephrotic proteinuria (54%), acute kidney injury (28%), nephrotic syndrome (23%), and chronic kidney disease (22%). Focal segmental glomerulosclerosis (28%), mainly the collapsing form (HIVAN), acute interstitial nephritis (AIN) (26%), and immune complex-mediated glomerulonephritis (ICGN) (25%) were the predominant renal histology. Baseline CD4 cell count ≥200 cells/mm3 was a protective factor against CKD (hazard ratio=0.997; 95%CI=0.994-0.999; P=0.012). At last follow-up, 64% of patients with baseline CD4 ≥200 cells/mm3 had eGFR >60 mL·min-1·(1.73 m2)-1 compared to the other 35% of patients who presented with CD4 <200 cells/mm3 (log rank=9.043, P=0.003). In conclusion, the main histological lesion of HIV-associated renal disease was HIVAN, followed by AIN and ICGN. These findings reinforce the need to biopsy HIV patients with kidney impairment and/or proteinuria. Baseline CD4 cell count ≥200 cells/mm3 was associated with better renal function after 2 years of follow-up.

Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis

Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies (ANCAs) and other autoantibodies. Here we report the case of a 49-year-old male who was a chronic cocaine user, and who presented spontaneous weight loss, arthralgia, and 3 weeks before admission purpuric skin lesions in the earlobes and in the anterior thighs. His laboratory tests on admission showed serum creatinine of 4.56 mg/dL, white blood count 3,800/μL, hemoglobin 7.3 g/dL, urinalysis with 51 white blood cells/μL and 960 red blood cells/μL, and urine protein-to-creatinine ratio 1.20. Serum ANCA testing was positive (>1:320), as well as serum anti-myeloperoxidase and anti-proteinase 3 antibodies. Urine toxicology screen was positive for cocaine and levamisole, with 62.8% of cocaine, 32.2% of levamisole, and 5% of an unidentified substance. Skin and renal biopsies were diagnostic for leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis, respectively. The patient showed a good clinical response to cocaine abstinence, and use of corticosteroids and intravenous cyclophosphamide. Last serum creatinine was 1.97 mg/dL, white blood cell count 7,420/μL, and hemoglobin level 10.8 g/dL. In levamisole-induced systemic vasculitis, the early institution of cocaine abstinence, concomitant with the use of immunosuppressive drugs in severe cases, may prevent permanent end organ damage and associate with better clinical outcomes.

Päällyskasvustot ja kasviplankton järvien ekologisen tilan arvioinnissa ja seurannassa

Selvityksessä testattiin perifytonin eli päällyskasvuston ja kasviplanktonin seurantaan sopivia menetelmiä. Työhön sisältyi myös kenttäkäyttöisen fluorometrin käytön testaus. Kohdejärvinä oli kaikkiaan 14 järveä Vuoksen vesistöalueella. Järvet edustivat erilaisia luontaisia järvityyppejä sekä kuormitustilanteita. Selvitys on osa Life Vuoksi -projektia, joka saa rahoitusta EU:n Life Ympäristö -rahastosta. Kohdejärvien perifytonkasvustoja tutkittiin sekä luonnonalustoilta, joita olivat kivet ja vesikasvit, että keinoalustoilta. Keinoalustanäytteistä analysoitiin kvantitatiivisina muuttujina a-klorofyllipitoisuus sekä kiintoaine. Kaikista näytteistä tehtiin lajiston yleiskatsaus eli määritettiin eri leväryhmien ja detrituksen osuudet. Lisäksi määritettiin piilevälajiston koostumus ja runsaussuhteet. Järvet erosivat toisistaan piilevien lajistokoostumuksen perusteella, mutta tulkinta ei ollut yksiselitteinen. Myös kvantitatiivisten tunnusten perusteella kuormitetut ja vertailujärvet erosivat toisistaan. Fluorometrilaitteisto oli toimiva, mutta vaatii vielä kehittelyä, jotta toiminta käytännössä olisi mahdollisimman sujuvaa. Kasviplanktonmenetelmistä valtalajilaskenta soveltui hyvin selittämään a-klorofyllituloksia ja antoi karkean yleiskuvan lajistosta. Vesien ekologisen laadun arviointiin (EQR-luku) käytettävien biomassojen laskentaan tarvittiin tarkempaa, kvantitatiivista analysointimenetelmää, sillä valtalajien määritys oli siihen tarkoitukseen liian yleispiirteinen. Aineistojen käyttöä järvien ekologisen tilan arvioinnissa kokeiltiin. Tavoitteena oli menettelytapojen kokeilu, sillä mm. vähäisen vertailuaineiston vuoksi varsinaisia tila-arvioita ei voitu luotettavasti tehdä.

Graduale (MS C.ö.III.17)

A Lutheran gradual from Kalanti. As covers used a fragment of the Liturgical calendar of the Diocese of Turku, Saec. XIV 2/2, Diocese of Turku.

Clinical and pathological correlations of C4d immunostaining and its infl uence on the outcome of kidney transplant recipients

INTRODUCTION: C4d is a marker of antibody-mediated rejection (ABMR) in kidney allografts, although cellular rejection also have C4d deposits. OBJECTIVE: To correlate C4d expression with clinico-pathological parameters and graft outcomes at three years. METHODS: One hundred forty six renal transplantation recipients with graft biopsies by indication were included. C4d staining was performed by paraffin-immunohistochemistry. Graft function and survival were measured, and predictive variables of the outcome were determined by multivariate Cox regression. RESULTS: C4d staining was detected in 48 (31%) biopsies, of which 23 (14.7%) had diffuse and 25 (16%) focal distribution. Pre-transplantation panel reactive antibodies (%PRA) class I and II were significantly higher in C4d positive patients as compared to those C4d negative. Both glomerulitis and pericapillaritis were associated to C4d (p = 0.002 and p < 0.001, respectively). The presence of C4d in biopsies diagnosed as no rejection (NR), acute cellular rejection (ACR) or interstitial fibrosis/ tubular atrophy (IF/TA) did not impact graft function or survival. Compared to NR, ACR and IF/TA C4d-, patients with ABMR C4d+ had the worst graft survival over 3 years (p = 0.034), but there was no difference between ABMR versus NR, ACR and IF/TA that were C4d positive (p = 0.10). In Cox regression, graft function at biopsy and high %PRA levels were predictors of graft loss. CONCLUSIONS: This study confirmed that C4d staining in kidney graft biopsies is a clinically useful marker of ABMR, with well defined clinical and pathological correlations. The impact of C4d deposition in other histologic diagnoses deserves further investigation.