Seasonal changes in the D/H ratio of fatty acids of pelagic microorganisms

Culture studies of microorganisms have shown that the hydrogen isotopic composition of fatty acids depends on their metabolism, but there are only few environmental studies available to confirm this observation. Here we studied the seasonal variability of the deuterium/hydrogen (D/H) ratio of fatty acids in the coastal Dutch North Sea and compared this with the diversity of the phyto- and bacterioplankton. Over the year, the stable hydrogen isotopic fractionation factor epsilon between fatty acids and water ranged between -172 per mil and -237 per mil, the algal-derived polyunsaturated fatty acid nC20:5 being the most D-depleted and nC18:0 the least D-depleted fatty acid. The D-depleted nC20:5 is in agreement with culture studies, which indicates that photoautotrophic microorganisms produce fatty acids which are significantly depleted in D relative to water. The epsilon-lipid/water of all fatty acids showed a transient shift towards increased fractionation during the spring phytoplankton bloom, indicated by increasing chlorophyll a concentrations and relative abundance of the nC20:5 PUFA, suggesting increased contributions of photoautotrophy. Time periods with decreased fractionation (less negative epsilon-lipid/water values) can be explained by an increased contribution by heterotrophy to the fatty acid pool. Our results show that the hydrogen isotopic composition of fatty acids is a useful tool to assess the community metabolism of coastal plankton.

The middle-income trap from the viewpoint of trade structures

In this study, we try to elucidate the middle-income trap from the viewpoint of international trade. We conduct regression analyses on the relationship between income level and net export ratios for different types of goods for trapped and non-trapped samples separately. Our findings indicate that industrial upgrading appears to occur exactly as depicted by the flying-geese model for non-trapped countries while trapped countries tend to depend on the export of primary commodities, and industrialization appears to be driven by forward linkages to processed goods and a narrow base. The results of our analyses suggest that the middle-income trap is a form of Dutch disease or a 'resource curse' in the middle-income stage.

Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein.

Cerebrovascular amyloid beta-protein (Abeta) deposition is a pathological feature of several related disorders including Alzheimer disease and hereditary cerebral hemorrhage with amyloidosis Dutch-type (HCHWA-D). HCHWA-D is caused by a point mutation in the gene that encodes the Abeta precursor and results in a Glu --> Gln substitution at position 22 of Abeta. In comparison to Alzheimer disease, the cerebrovascular Abeta deposition in HCHWA-D is generally more severe, often resulting in intracerebral hemorrhage when patients reach 50 years of age. We recently reported that Abeta(1-42), but not the shorter Abeta(1-40) induces pathologic responses in cultured human leptomeningeal smooth muscle cells including cellular degeneration that is accompanied by a marked increase in the levels of cellular Abeta precursor and soluble Abeta peptide. In the present study, we show that the HCHWA-D mutation converts the normally nonpathologic Abeta(1-40) into a highly pathologic form of the peptide for cultured human leptomeningeal smooth muscle cells. These findings suggest that these altered functional properties of HCHWA-D mutated Abeta may contribute to the early and often severe cerebrovascular pathology that is the hallmark of this disorder.

A new rodent from Dutch New Guinea [by] Wilfred H. Osgood.

v.31:no.1(1945)

The Hague, Netherlands, 1891 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Nieuwste plan van 's Gravenhage : met de verschillende hieuwe bouwplannen, John C. Bignell graveur. It was published by John C. Bignell in 1891. Scale 1:10,000. Covers The Hague, Netherlands. Map in Dutch. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'RD_New (Rijksdriehoekstelsel), GCS Amersfoort' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads and stations, street-railroads, drainage, canals, built-up areas and selected buildings, ground cover, parks, cemeteries, and more. Includes also index and advertisements in margins.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

The Hague, Netherlands, 1695 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Haga comitis vulgo 'S Graven-Hage, F. de Wit. It was published by F. de Wit in 1695. Scale [ca.1:1,982]. Covers The Hague, Netherlands. Map in Latin and Dutch. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'RD_New (Rijksdriehoekstelsel), GCS Amersfoort' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, canals, ground cover, windmills, parks, and more. Relief shown pictorially. Includes index. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

The Hague, Netherlands, 1745 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: 's-Gravenhage : en de omgelegen landstreek volgens de nauwkeurige, metting van N. Cruquius. It was published by Isaak Tirion in 1745. Scale [ca.1:37,650]. Covers The Hague, Netherlands. Map in Dutch. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'RD_New (Rijksdriehoekstelsel), GCS Amersfoort' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, ground cover, canals, windmills, and more. Relief shown pictorially. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

The Hague, Netherlands, 1747 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Nieue afbeelding' van S. Gravenhage = Nouveau plan de la Haye, in S. Hage by D. Langeweg boek en kaartverkoper in de Vlaming straat ; I.V. Besoet, fecit. It was published by chez Daniel Langeweg in 1747. Scale [ca.1:3,765]. Covers The Hague, Netherlands. Map in Dutch and French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'RD_New (Rijksdriehoekstelsel), GCS Amersfoort' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, ground cover, canals, windmills, and more. Relief and buildings shown pictorially. Includes index. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

The Hague, Netherlands, 1889 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Nieuw plan van 's Gavenhage : 1889. It was published by Tj. Van Holkema in 1889. Scale [ca. 1:6,300]. Covers The Hague, Netherlands. Map in Dutch. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'RD_New (Rijksdriehoekstelsel), GCS Amersfoort' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, street-railroads, drainage, canals, built-up areas and selected buildings, windmills, ground cover, parks, and more. Includes insets: Scheveningsche Park en Boschjes -- [Haagsche Bosch] -- [Scheveningen]. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Amsterdam Region, the Netherlands, 1749 (Image 1 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Kaarte van alle de dykpligtige en eenige waalpligtige landen behorende onder het Hoogreemraadschap van den Zeeburg en Diemerdyk, J. Wandelaar, delin. et sculpsit. It was published in 1749. Scale [ca. 1:6,000]. This layer is image 1 of 3 total images of the three sheet source map, representing the northern portion of the map. Covers the region east of Amsterdam, the Netherlands including portions of Gemeente Amsterdam, Gemeente Diemen, Gemeente Muiden, and Gemeente Weesp. Map in Dutch.The image inside the map neatline is georeferenced to the surface of the earth and fit to the RD_New (Rijksdriehoekstelsel), GCS Amersfoort coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, canals, cities and other human settlements, administrative boundaries, roads, propery boundaries with names of landowners, selected buildings and built-up areas, fortification, dikes, dams, windmills, shoreline features, and more. Relief shown by hachures. Depths shown by soundings.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Amsterdam Region, the Netherlands, 1749 (Image 2 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Kaarte van alle de dykpligtige en eenige waalpligtige landen behorende onder het Hoogreemraadschap van den Zeeburg en Diemerdyk, J. Wandelaar, delin. et sculpsit. It was published in 1749. Scale [ca. 1:6,000]. This layer is image 2 of 3 total images of the three sheet source map, representing the central portion of the map. Covers the region east of Amsterdam, the Netherlands including portions of Gemeente Amsterdam, Gemeente Diemen, Gemeente Muiden, and Gemeente Weesp. Map in Dutch.The image inside the map neatline is georeferenced to the surface of the earth and fit to the RD_New (Rijksdriehoekstelsel), GCS Amersfoort coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, canals, cities and other human settlements, administrative boundaries, roads, propery boundaries with names of landowners, selected buildings and built-up areas, fortification, dikes, dams, windmills, shoreline features, and more. Relief shown by hachures. Depths shown by soundings.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.