Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight

Sugar intake has dramatically increased during the last few decades. Specifically, there has been a clear trend towards higher consumption of fructose and high fructose corn syrup, which are the most common added sugars in processed food, soft drinks and other sweetened beverages. Although still controversial, this rising trend in simple sugar consumption has been positively associated with weight gain and obesity, insulin resistance and type 2 diabetes mellitus and non-alcoholic fatty liver disease. Interestingly, all of these metabolic alterations have also been related to the development of hepatocellular carcinoma. The purpose of this review is to discuss the evidence coming from epidemiological studies and data from animal models relating the consumption of simple sugars, and specifically fructose, with an increased risk of hepatocellular carcinoma and to gain insight into the putative molecular mechanisms involved.

Supervised regionalization methods: A survey

This paper reviews almost four decades of contributions on the subject of supervised regionalization methods. These methods aggregate a set of areas into a predefined number of spatially contiguous regions while optimizing certain aggregation criteria. The authors present a taxonomic scheme that classifies a wide range of regionalization methods into eight groups, based on the strategy applied for satisfying the spatial contiguity constraint. The paper concludes by providing a qualitative comparison of these groups in terms of a set of certain characteristics, and by suggesting future lines of research for extending and improving these methods.

Patrones de publicación internacional, (ssci) de los autores afiliados a universidades españolas, en el ámbito económico-empresarial (1994-2004)

In this paper we analyse the status of scientific publications in Economics and Business in Spain (1994-2004). We focus our research in showing the preferred journals of the authors affiliated to Spanish universities, the quality of these journals and also the evolution along the decade. Throughout the paper we study deeply the areas of knowledge: which are more productive and also how the articles are distributed among Universities considering the areas of knowledge. The results show an important stability concerning the growth of published articles considering different levels of quality of journals. A second result is the important concentration in a few areas of knowledge: Fundamentals of Economic Analysis and Applied Economics. We observe a degree of specialization of several universities. Last, we display the relationship between journal publication and university’s publication pattern.

Research networks and scientific production in Economics: The recent spanish experience

This paper studies Spanish scientific production in Economics from 1994 to 2004. It focuses on aspects that have received little attention in other bibliometric studies, such as the impact of research and the role of scientific collaborations in the publications produced by Spanish universities. Our results show that national research networks have played a fundamental role in the increase in Spanish scientific production in this discipline.

La investigación regional en España: un análisis bibliométrico

Este trabajo analiza cual ha sido la evolución de la investigación en ciencia regional y urbana en España en el período 1991-2000 situándola en el contexto internacional. Para ello, se elaboran rankings de países, autores e instituciones en función de las publicaciones realizadas en una muestra de nueve revistas internacionales ampliamente reconocidas dentro de este campo. Los resultados muestran que la mejora en la posición relativa a nivel internacional encontrada por otros autores para el conjunto de la investigación española en economía también se produce en el contexto de la investigación económica regional y urbana De hecho, hay un claro aumento de la presencia a nivel internacional de los autores e instituciones españolas motivado en buena medida por un incremento de las publicaciones de autores con tradición en la investigación en ciencia regional y urbana pero también por la irrupción con fuerza de 'nuevos' autores.

La investigación regional en España. Rankings de países, instituciones y autores en ciencia regional y urbana para el período 1991-2000

Este trabajo analiza cual ha sido la evolución de la investigación en ciencia regional y urbana en España en el período 1991-2000 situándola en el contexto internacional. Para ello, se elaboran rankings de países, autores e instituciones en función de las publicaciones realizadas en una muestra de nueve revistas internacionales ampliamente reconocidas dentro de este campo. Los resultados muestran que la mejora en la posición relativa a nivel internacional encontrada por otros autores para el conjunto de la investigación española en economía también se produce en el contexto de la investigación económica regional y urbana De hecho, hay un claro aumento de la presencia a nivel internacional de los autores e instituciones españolas motivado en buena medida por un incremento de las publicaciones de autores con tradición en la investigación en ciencia regional y urbana pero también por la irrupción con fuerza de 'nuevos' autores.

Is the wage curve formal or informal? Evidence for Colombia

The objective of this paper is to analyse the existente or not of a wage curve in Colombia, paying special attention to the differences between formal and informal workers, an issue that has been systematically ignored in the wage curve literature. The obtained results using microdata from the Colombian Continuous Household Survey (CHS) between 2002 and 2006 show the existence of a wage curve with a negative slope for the Colombian economy. Using information on metropolitan areas, the estimates of the elasticity of individual wages to local unemployment rates was -0.07, a value that is very close to those obtained for other countries. However, the disaggregation of statistical information for formal and informal workers has shown significant differences among both groups of workers. In particular, for the less protected groups of the labour market, informal workers (both men and women), a high negatively sloped wage curve was found. This result is consistent with the conclusions from efficiency wage theoretical models and should be taken into account when analysing the functioning of regional labour markets in developing countries.

Ecological fallacy in a time series context: evidence from the Spanish regional unemployment rates

The ecological fallacy (EF) is a common problem regional scientists have to deal with when using aggregated data in their analyses. Although there is a wide number of studies considering different aspects of this problem, little attention has been paid to the potential negative effects of the EF in a time series context. Using Spanish regional unemployment data, this paper shows that EF effects are not only observed at the cross-section level, but also in a time series framework. The empirical evidence obtained shows that analytical regional configurations are the least susceptible to time effects relative to both normative and random regional configurations, while normative configurations are an improvement over random ones.

Supervised regionalization methods: A survey

This paper reviews almost four decades of contributions on the subject of supervised regionalization methods. These methods aggregate a set of areas into a predefined number of spatially contiguous regions while optimizing certain aggregation criteria. The authors present a taxonomic scheme that classifies a wide range of regionalization methods into eight groups, based on the strategy applied for satisfying the spatial contiguity constraint. The paper concludes by providing a qualitative comparison of these groups in terms of a set of certain characteristics, and by suggesting future lines of research for extending and improving these methods.

Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Most morbidity associated with the metabolic syndrome is related to vascular complications, in which endothelial dysfunction is a major pathogenic factor. However, whether NAFLD is associated with endothelial dysfunction within the hepatic vasculature is unknown. The aims of this study were to explore, in a model of diet-induced overweight that expresses most features of the metabolic syndrome, whether early NAFLD is associated with liver endothelial dysfunction. Wistar Kyoto rats were fed a cafeteria diet (CafD; 65% of fat, mostly saturated) or a control diet (CD) for 1 month. CafD rats developed features of the metabolic syndrome (overweight, arterial hypertension, hypertryglyceridemia, hyperglucemia and insulin resistance) and liver steatosis without inflammation or fibrosis. CafD rats had a significantly higher in vivo hepatic vascular resistance than CD. In liver perfusion livers from CafD rats had an increased portal perfusion pressure and decreased endothelium-dependent vasodilation. This was associated with a decreased Akt-dependent eNOS phosphorylation and NOS activity. In summary, we demonstrate in a rat model of the metabolic syndrome that shows features of NAFLD, that liver endothelial dysfunction occurs before the development of fibrosis or inflammation.

La producción científica en el ámbito de la Economía y Empresa en España. Rankings de las universidades españolas en términos de producción, productividad, calidad e impacto en el período 1994-2003.

En este trabajo se analiza la situación de las publicaciones científicas en Economía y Empresa en España en el decenio 1994-2003. En concreto se analizan la producción de artículos, la productividad por investigador, la calidad de las publicaciones y su impacto (citas) y se elaboran rankings de las universidades españolas. Los principales resultados apuntan a unos niveles de producción científica que evolucionan de manera creciente en los últimos años. Esta mejora se debe al incremento de la plantilla y, sobre todo, al incremento de su productividad.

Wages and productivity: the role of labour market institutions in OECD countries

In the context of a monetary union, to keep a territorial equilibrium in terms of economic activity and employment, the relationship between real wages and productivity is crucial. In this paper, empirical evidence about the response of wages to productivity is obtained for 20 OECD countries and the role of labour market institutions to explain differences in this response is analysed.

Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009-2010

The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI≥40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population

La naturaleza jurídica de la responsabilidad civil ex delicto: o cómo 'resolver' la cuadratura del círculo

El presente trabajo versa sobre una cuestión nominal y materialmente zanjada por la doctrina civil y penal como es la naturaleza jurídica de la RC ex delicto. Sin embargo, a juicio del autor, se trata de una problemática todavía viva. No se defiende la mutación penal de la responsabilidad civil derivada de delito. Pero sí se hace especial hincapié en los relevantes efectos punitivos a ella asignados, en su carácter no sólo y exclusivamente civil, así como en la existencia de un interés público que trasciende a las partes en conflicto y que justificaría su ejercicio en el proceso penal por el Ministerio Fiscal.

Effects of solar activity and climate variability on large floods in Switzerland

The paper presents the variability of major floods in Switzerland for the period 1800-2008 from a summer index (INU). The index is constructed from the damage caused by flooding, with the aim of establishing the possible influence of the solar and climate variability on the major floods. The coincidence of flood-rich periods with those observed in other regions of different climate and fluvial regimes suggests that climate forcings and changes in the general circulation of the atmosphere are those who govern the appearance of these high-frequency temporal clusters.