Interaction of small molecules with specific immune receptors: the p-i concept and its consequences

Drugs may stimulate the immune system by forming stable new antigenic complexes consisting of the drug or drug metabolite which is covalently bound to a protein or peptide (hapten-carrier complex). Both, B- and T-cell immunity may arise, the latter directed to hapten modified peptides presented by HLA molecules. Beside this immunological stimulation, drugs can also stimulate the immune system through binding by non-covalent bonds to proteins like immune receptors. This so-called “pharmacological interaction with immune receptors” concept (“p-i concept”) may occur with HLA or TCR molecules themselves (p-i HLA or p-i TCR), and not the immunogenic peptide. It is a type of “off-target” activity of the drug on immune receptors, but more complex as various cell types, cell interactions and functionally different T cells are involved. In this review the conditions which lead to activation of T cells by p-i are discussed: important factors for a functional consequence of drug binding is the location of binding (p-i HLA or p-i TCR); the exact site within these immune receptors; the affinity of binding and the finding that p-i HLA can stimulate the immune system like an allo-allele. The p-i concept is able to solve some puzzles of drug hypersensitivity reactions and are a basis to better treat and potentially avoid drug hypersensitivity reactions. Moreover, the p-i concept shows that in contrast to previous beliefs small molecules do interact with immune receptors with functional consequence. But these interactions are not based on “immune recognition”, are at odds with some immunological concepts, but may nevertheless open new possibilities to understand and even treat immune reactions

Adsorption of Ni(2+), Zn(2+) and Pb(2+) onto dry biomass of Arthrospira (Spirulina) platensis and Chlorella vulgaris. I. Single metal systems

Adsorption of Ni(2+), Zn(2+) or Pb(2+) by dry biomass of Arthrospira (Spirulina) platensis and Chlorella vulgaris was studied as a function of contact time and initial metal concentration. The zero point of charge calculated for these biosorbents (pH(zpc) 4.0 and 3.4, respectively) and additional pH tests suggested the use of pH in the range 5.0-5.5 for the experiments. The equilibrium isotherms were evaluated in terms of maximum sorption capacity and sorption affinity. The pseudo first and second order kinetic models were considered to interpret the experimental data, and the latter best described the adsorption system. Both the Freundlich and Langmuir models were shown to well describe the sorption isotherms, thus suggesting an intermediate mono/multilayer sorption mechanism. Compared to A. platensis (q(e) = 0.354, 0.495 and 0.508 mmol g(-1) for Ni(2+), Pb(2)+ and Zn(2+), respectively), C. vulgaris behaved as a better biosorbent because of higher equilibrium sorption capacity (q(e) = 0.499, 0.634 and 0.664 mmol g(-1), respectively). The removal efficiency decreased with increasing metal concentration, pointing out a passive adsorption process involving the active sites on the surface of the biomasses. The FT-IR spectroscopy evidenced that ions removal occurred mainly by interaction between metal and carboxylate groups present on both the cell walls. (C) 2011 Elsevier B.V. All rights reserved.

Cognitive models for the concept of angle

Tese de doutoramento em Filosofia

Standards for Single Span Prefabricated Bridges, Phase I - Concept Development, TR-663, 2014

In coordination with a Technical Advisory Committee (TAC) consisting of County Engineers and Iowa DOT representatives, the Iowa DOT has proposed to develop a set of standards for a single span prefabricated bridge system for use on the local road system. The purpose of the bridge system is to improve bridge construction, accelerate project delivery, improve worker safety, be cost effective, reduce impacts to the travelling public by reducing traffic disruptions and the duration of detours, and allow local forces to construct the bridges. HDR Inc. was selected by the Iowa DOT to perform the initial concept screening of the bridge system. This Final Report summarizes the initial conceptual effort to investigate potential systems, make recommendations for a preferred system and propose initial details to be tested in the laboratory in Phase 2 of the project. The prefabricated bridge components were to be based on the following preliminary criteria set forth by the TAC. The criteria were to be verified and/ or modified as part of the conceptual development. - 24’ and 30’ roadway widths - Skews of 0o, 15o, and 30o - Span lengths of 30’ – 70’ in 10’ increments using precast concrete beams - Voided box beams could be considered - Limit precast element weight to 45,000 pounds for movement and placement of beams - Beams could be joined transversely with threaded rods - Abutment concepts may included precast as well as an option for cast-in-place abutments with pile foundations In addition to the above criteria, there was an interest to use a single-width prefabricated bridge component to simplify fabrication as well as a desire to utilize non-prestressed concrete systems where possible to allow for precasting of the beam modules by local forces or local precast plants. The SL-1 modular steel bridge rail was identified for use with this single span prefabricated bridge system.

Human factors requirements for real-time motorist information displays. Volume 3: summary of systems in the United States. Final report.

Federal Highway Administration, Office of Research, Washington, D.C.

Способы лексикализации события движения в русском языке в сопоставлении с итальянским

В данной работе рассматривается лексикализация события движения в русском языке в сопоставлении с итальянским. Цель нашей работы двойная: с одной стороны, мы рассмотрим пространственную семантику выбранных нами глагольных префиксов и определим их семантический вклад в лексикализацию события движения. С другой стороны, мы проанализируем соответствия русских приставочных глаголов движения при переводе на итальянский язык. В частности, мы сосредоточимся на том, выражается ли вклад префикса, передается ли он полностью или частично, какие нюансы его пространственной семантики могут опускаться, а какие выражаются обязательно и какими языковыми средствами. Работа состоит из введения, трех глав и заключения. В Первой главе представляется теоретическая рамка, на которую опирается сопоставительный анализ. Рассматриваются понятия движения и перемещения согласно семантическим толкованиям, приведенным как в русскоязычной литературе, так и в работах на других языках. Кроме того, концептуализация пространства описывается в русле когнитивного подхода к изучению языка. Представлена классификация языков по лексикализации события движения, введенной Л. Талми, а также основные последующие исследования, посвященные лексикализации события движения в различных языках, проведенные в русле типологического подхода. Отдельный параграф первой главы посвящается вкладу исследований, проведенных Д. Слобиным в области лексикализации компонентов движения, в частности, способа движения в различных языках. Во Второй главе описываются система бесприставочных глаголов движения в русском языке и основные подходы к их изучению. Регулярно проводятся параллели с итальянской системой глаголов движения. Далее в этой главе представлен обзор системы приставочных глаголов движения русского языка. Отдельно мы рассматриваем главные подходы к изучению семантики глагольных префиксов, фокусируясь на их пространственных значениях. В Третьей главе представляется подбор глагольных префиксов с пространственной семантикой, выбранных для целей сопоставительного анализа. Для каждого префикса предлагается словарное толкование, описывается его пространственная семантика согласно концепциям, разработанным различными авторами, и проводится анализ контекстов употребления приставочных глаголов в русском языке и возможные стратегии их передачи на итальянский язык. Выводы изложены в заключении, прилагается также список литературы.

Neurocognitive profile and cognitive intervention in Alzheimer's disease

Tese de Doutoramento em Psicologia (Especialidade de Psicologia Clínica)

Development of LRFD Procedures for Bridge Pile Foundations in Iowa Volume III: Recommended Resistance Factors with Consideration of Construction Control and Setup, TR-584, 2012

The Federal Highway Administration (FHWA) mandated utilizing the Load and Resistance Factor Design (LRFD) approach for all new bridges initiated in the United States after October 1, 2007. As a result, there has been a progressive move among state Departments of Transportation (DOTs) toward an increased use of the LRFD in geotechnical design practices. For the above reasons, the Iowa Highway Research Board (IHRB) sponsored three research projects: TR-573, TR-583 and TR-584. The research information is summarized in the project web site (http://srg.cce.iastate.edu/lrfd/). Two reports of total four volumes have been published. Report volume I by Roling et al. (2010) described the development of a user-friendly and electronic database (PILOT). Report volume II by Ng et al. (2011) summarized the 10 full-scale field tests conducted throughout Iowa and data analyses. This report presents the development of regionally calibrated LRFD resistance factors for bridge pile foundations in Iowa based on reliability theory, focusing on the strength limit states and incorporating the construction control aspects and soil setup into the design process. The calibration framework was selected to follow the guidelines provided by the American Association of State Highway and Transportation Officials (AASHTO), taking into consideration the current local practices. The resistance factors were developed for general and in-house static analysis methods used for the design of pile foundations as well as for dynamic analysis methods and dynamic formulas used for construction control. The following notable benefits to the bridge foundation design were attained in this project: 1) comprehensive design tables and charts were developed to facilitate the implementation of the LRFD approach, ensuring uniform reliability and consistency in the design and construction processes of bridge pile foundations; 2) the results showed a substantial gain in the factored capacity compared to the 2008 AASHTO-LRFD recommendations; and 3) contribution to the existing knowledge, thereby advancing the foundation design and construction practices in Iowa and the nation.

Llenguatge i decisions morals

'Què faries si l"única manera de salvar cinc persones d"una mort segura a causa d"un accident atzarós fos provocar expressament la mort d"una altra persona que no està en perill?" No és una pregunta fàcil, ni la resposta trivial. Prenem decisions constantment, sovint intranscendents-quina camisa em poso avui?-, però també moltes que tenen un cert component moral, que poden afectar altres persones.

Formal semantics for propositional attitudes

Contemporary logic is confined to a few paradigmatic attitudes such as belief, knowledge, desire and intention. My purpose is to present a general model-theoretical semantics of propositional attitudes of any cognitive or volitive mode. In my view, one can recursively define the set of all psychological modes of attitudes. As Descartes anticipated, the two primitive modes are those of belief and desire. Complex modes are obtained by adding to primitive modes special cognitive and volitive ways or special propositional content or preparatory conditions. According to standard logic of attitudes (Hintikka), human agents are either perfectly rational or totally irrational. I will proceed to a finer analysis of propositional attitudes that accounts for our imperfect but minimal rationality. For that purpose I will use a non standard predicative logic according to which propositions with the same truth conditions can have different cognitive values and I will explicate subjective in addition to objective possibilities. Next I will enumerate valid laws of my general logic of propositional attitudes. At the end I will state principles according to which minimally rational agents dynamically revise attitudes of any mode.

La ambigüedad, las creencias y los estereotipos que rodean a lo que hoy en día se conoce como terrorismo: Una revisión de literatura

El terrorismo en la actualidad es considerado como uno de los conceptos más controversiales en los campos social, académico y político. El término se empieza a utilizar después de la Revolución Francesa, pero recientemente, a raíz de los atentados del 11 de septiembre de 2001, ha tomado suma relevancia y ha motivado numerosas investigaciones para tratar de entender qué es terrorismo. Aunque a la fecha existen varias revisiones sistemáticas, este trabajo tiene como propósito revisar, agrupar y concretar diferentes teorías y conceptos formulados por los autores que han trabajado sobre el concepto de “terrorismo” con el fin de entender las implicaciones de su utilización en el discurso, y cómo esto afecta la dinámica interna de las sociedades en relación con la violencia, las creencias, los estereotipos entre otros elementos. Para lograrlo, se revisaron 56 artículos, publicados entre los años 1985 y 2013; 10 fuentes secundarias entre noticias y artículos de periódicos correspondientes a los años 1995-2013 y 10 estudios estadísticos cuyos resultados nos aportan a la comprensión del tema en cuestión. La búsqueda se limitó al desarrollo histórico del terrorismo, sus diferentes dimensiones y el concepto social de la realidad de terrorismo. Los hallazgos demuestran que la palabra “terrorismo” constituye un concepto que como tal es un vehículo lingüístico que puede ser utilizado con fines, estratégicos movilizando al público conforme a través del discurso e intereses políticos, destacando la necesidad de estudiar las implicaciones psicológicas y sociales de su uso.