Efeito sinérgico entre a terapia fotodinâmica e a cisplatina: uma nova abordagem para o câncer de colo uterino

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Degradação de forças dos elasticos intermaxilares ortodônticos sintéticos

This study aimed to evaluate the force degradation of synthetic elastics over time using dynamic biomechanical tests in order to find clinical parameters of what size of elastic and frequency of exchange should be used in orthodontic therapy. It was used 240 elastics of Dental Morelli, sizes 1/8", 3/16", 1/4 "and 5/16", medium force, divided in four groups. In each group was measured forces at different times, from immediate to 72 hours after immersion in water at 37°C and incubated stretched to 600% of its initial inner diameter. Tensile tests were performed on a universal testing machine EMIC DL2000 submerged in distilled water maintained at 37°C. Data were analyzed using SPSS version 16.0, by the Analysis of Variance (One-Way) with Tukey´s post test. There was a greater increase in pattern of force decay of immediate measurement until 24 hours in all sizes of synthetic elastics, from which it was observed a decrease in force progressively smaller, with the exception of 5/16´´ elastic with a maximum force decay occurred at 12h. It was concluded that: the elastic synthetic Dental Morelli suffered significant force degradation over time, with reduction of approximately 70% of the initial force during 24 hours of stretching, followed by a progressively smaller decrease; the amount of stretch for a ideal force in intermaxillary therapies depends on the distance between the points of attachment of elastic, being necessary to consult the tables to choose the size, force and frequency of replacement.

Hipersensibilidade dentinária cervical: em busca de um tratamento eficaz

The knowledge of the etiology of any disease or condition is paramount to a safe and effective treatment. This literature review aims to show some options to treat dentine hypersensitivity (HSDC). The loss of cervical enamel and cementum exposure of tubules leads to a painful condition and patient discomfort, called HSDC. This loss of tooth structure occurs due to formation of cervical lesions in cases of gingival recession, abrasion, erosion, or abfraction by the association of two or more factors. Some treatments are not effective, but there are effective therapies, such as: application of ferric oxalate, potassium oxalate, potassium nitrate, fluoride varnish, solutions of calcium phosphate, adhesives and Bonding procedures. Therefore, the identification and removal of etiological factors is essential to successful treatment of HSDC normally associated to tubules obliterate and consequent reduction of fluid motion within the dentin.

Feliz para sempre? Uma análise dos efeitos do uso a longo prazo de antidepressivos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Derivação de células tronco de tecido ovariano na espécie canina

Pós-graduação em Medicina Veterinária - FCAV

Cell therapy in experimental model of inflammatory bowel disease

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

Musculoskeletal injuries that occur in horses during sports activities are often disabling and require a long period of treatment and rehabilitation, most resulting in scar tissue, predisposing to recurrence. In search of more effective therapies and tissue regeneration, studies have been carried out with blood derivatives - platelet rich plasma and autologous conditioned serum. In spite of both being blood-derived therapies, platelet rich plasma and autologous conditioned serum are distinct products, with equally distinct indications for their use. Platelet rich plasma shows promising results in ligament and tendon injuries in clinical and experimental trials. This occurs also in osteoarticular lesions with both hemoderivates, autologous conditioned serum and platelet rich plasma. This review aims to present clinical and experimental studies (in vivo and in vitro) in the equine species, as an aid for an appropriate therapeutic choice, when hemoderivates are considered for treatment of musculoskeletal lesions.

Diretrizes de conduta e tratamento de síndromes febris periódicas associadas à criopirina (Criopirinopatias–CAPS)

To establish guidelines based on cientific evidences for the management of cryopyrin associated periodic syndromes. The Guideline was prepared from 4 clinical questions that were structured through Pico (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 1215 articles were retrieved and evaluated by title and abstract; from these, 42 articles were selected to support the recommendations. 1. The diagnosis of Caps is based on clinical history and clinical manifestations, and later confirmed by genetic study. Caps may manifest itself in three phenotypes: FCAS (mild form), MWS (intermediate form) and Cinca (severe form). Neurological, ophthalmic, otorhinolaryngological and radiological assessments may be highly valuable in distinguishing between syndromes; 2. The genetic diagnosis with NLRP3 gene analysis must be conducted in suspected cases of Caps, i.e., individuals presenting before 20 years of age, recurrent episodes of inflammation expressed by a mild fever and urticaria; 3. Laboratory abnormalities include leukocytosis and elevated serum levels of inflammatory proteins; 4. Targeted therapies directed against interleukin-1 lead to rapid remission of symptoms in most patients. However, there are important limitations on the long-term safety. None of the three anti-IL-1β inhibitors prevents progression of bone lesions.

Efeitos das formulações nanoestruturadas de doxorrubicina e cisplatina em dispersão de óxido de grafeno reduzido no tratamento da progressão do câncer de bexiga Não-músculo invasivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Linfoma de Hodgkin: características anátomo-clínicas e análise de novo biomarcador (IMP3)

Pós-graduação em Patologia - FMB

Avaliação do potencial antioxidante e antiglicante de fitoterápicos utilizados para os sintomas de climatério

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Nefroblastoma em cão de 4 meses: relato de caso

Renal nephroblastoma is a malignant tumor composed by embryonic tissue that affects mainly puppies. This works reports the occurrence of unilateral renal nephroblastoma in a puppy with four months. The diagnosis was obtained by histopathological examination of mass obtained by exploratory laparotomy, with realization of nephrectomy. The animal died at 15 days post-operatively by the presence of pulmonary metastases. The survival rate with surgical excision of the mass, with or without complementary therapies, can vary with the stage of disease.

Vacina de DNA: uma alternativa para o tratamento do melanoma canino: revisão de literatura

O melanoma é considerado um dos tumores cutâneos de maior importância em cães devido ao seu caráter agressivo, à capacidade de produzir metástases em estágios precoces e à baixa resposta aos tratamentos não cirúrgicos. Recentemente, as vacinas de DNA apresentam-se promissoras na terapêutica do melanoma canino. O objetivo deste trabalho é apresentar uma revisão bibliográfica sobre o assunto. As vacinas de DNA são baseadas em plasmídeos que contêm o gene codificante para o antígeno alvo, expressando-o na célula do hospedeiro e apresentando, assim, vantagens em relação às vacinas tradicionais, como: facilidade de produção, estabilidade térmica, baixo custo e estimulação da resposta imune celular (linfócitos T CD8+). Devido ao sucesso limitado das terapias padrões, o estabelecimento de uma vacina de DNA efetiva aumenta a possibilidade de uma terapia promissora para o melanoma canino, podendo trazer novas expectativas aos animais portadores dessa neoplasia.

Ozônioterapia no controle da infecção em cirurgia oral

The objective of the literature review showing their main biological properties involved in the tissue repair process and its therapeutic potential in the prevention , control and treatment of infection in oral surgeries . To carry out this study , a search of the PubMed database . 13 articles that met the inclusion criteria were found . Antimicrobial properties , antiálgicas , anti-inflammatory , imunu - stimulants , oxygenation and neoangiogenesis were attributed to ozone in several studies . And indications such as the treatment of alveolitis , osteomyelitis , osteonecrosis , wound healing in skin and mucosa and antisepsis been suggested. However , many of its effects have not been well understood. The doses and concentrations for their use are not standardized . Studies to establish doses and periods of administration are still needed for increasingly traumatic and biologically effective therapies are found to practice dentistry .

Avaliação clínica da efetividade do clareamento de consultório sem troca do gel clareador

Esse trabalho teve como objetivo avaliar, clinicamente, a efetividade de dois agentes clareadores aplicados sobre a superfície dentária durante 45 minutos, sem troca do gel. Foram selecionados 10 pacientes de acordo com os critérios de inclusão e exclusão, e a arcada superior dos pacientes foi dividida em duas hemiarcadas (n = 10): na hemiarcada direita (HD), foi aplicado o peróxido de hidrogênio a 35% (PH) Clàriant Office (Angelus); e, na hemiarcada esquerda (HE), o PH 38% Opalescence Boost (Ultradent). Foram realizadas duas sessões clínicas, de 45 minutos cada, com intervalo de uma semana entre as sessões. Inicialmente, ao tratamento clareador, os pacientes receberam profilaxia, moldagem para guia de mensuração de cor com silicone de condensação e avaliação de cor por meio de um aparelho espectrofotômetro Vita Easyshade (Vita Zhanfabrik, Alemanha). Após 14 dias do término do tratamento clareador, foi realizada a mensuração final da cor dos dentes. Os dados foram submetidos ao teste t e de Tukey (p < 0,05). Os resultados demonstraram não haver diferença estatisticamente significativa entre as hemiarcadas quanto à efetividade do clareamento (p = 0,146) e nem quanto à sensibilidade. Pode-se concluir que a aplicação dos materiais avaliados sem troca do gel, por 45 minutos, foi eficaz em promover o clareamento de dentes vitais e com baixa sensibilidade dentária.