Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania : an open label prospective study

Background: Home-management of malaria (HMM) strategy improves early access of anti-malarial medicines to high-risk groups in remote areas of sub-Saharan Africa. However, limited data are available on the effectiveness of using artemisinin-based combination therapy (ACT) within the HMM strategy. The aim of this study was to assess the effectiveness of artemether-lumefantrine (AL), presently the most favoured ACT in Africa, in under-five children with uncomplicated Plasmodium falciparum malaria in Tanzania, when provided by community health workers (CHWs) and administered unsupervised by parents or guardians at home. Methods: An open label, single arm prospective study was conducted in two rural villages with high malaria transmission in Kibaha District, Tanzania. Children presenting to CHWs with uncomplicated fever and a positive rapid malaria diagnostic test (RDT) were provisionally enrolled and provided AL for unsupervised treatment at home. Patients with microscopy confirmed P. falciparum parasitaemia were definitely enrolled and reviewed weekly by the CHWs during 42 days. Primary outcome measure was PCR corrected parasitological cure rate by day 42, as estimated by Kaplan-Meier survival analysis. This trial is registered with ClinicalTrials.gov, number NCT00454961. Results: A total of 244 febrile children were enrolled between March-August 2007. Two patients were lost to follow up on day 14, and one patient withdrew consent on day 21. Some 141/241 (58.5%) patients had recurrent infection during follow-up, of whom 14 had recrudescence. The PCR corrected cure rate by day 42 was 93.0% (95% CI 88.3%-95.9%). The median lumefantrine concentration was statistically significantly lower in patients with recrudescence (97 ng/mL [IQR 0-234]; n = 10) compared with reinfections (205 ng/mL [114-390]; n = 92), or no parasite reappearance (217 [121-374] ng/mL; n = 70; p <= 0.046). Conclusions: Provision of AL by CHWs for unsupervised malaria treatment at home was highly effective, which provides evidence base for scaling-up implementation of HMM with AL in Tanzania.

qtl.outbred: Interfacing outbred line cross data with the R/qtl mapping software

Background qtl.outbred is an extendible interface in the statistical environment, R, for combining quantitative trait loci (QTL) mapping tools. It is built as an umbrella package that enables outbred genotype probabilities to be calculated and/or imported into the software package R/qtl. Findings Using qtl.outbred, the genotype probabilities from outbred line cross data can be calculated by interfacing with a new and efficient algorithm developed for analyzing arbitrarily large datasets (included in the package) or imported from other sources such as the web-based tool, GridQTL. Conclusion qtl.outbred will improve the speed for calculating probabilities and the ability to analyse large future datasets. This package enables the user to analyse outbred line cross data accurately, but with similar effort than inbred line cross data.

Geoprocessing journey-to-work data : delineating commuting regions in Dalarna, Sweden

Delineation of commuting regions has always been based on statistical units, often municipalities or wards. However, using these units has certain disadvantages as their land areas differ considerably. Much information is lost in the larger spatial base units and distortions in self-containment values, the main criterion in rule-based delineation procedures, occur. Alternatively, one can start from relatively small standard size units such as hexagons. In this way, much greater detail in spatial patterns is obtained. In this paper, regions are built by means of intrazonal maximization (Intramax) on the basis of hexagons. The use of geoprocessing tools, specifically developed for the processing ofcommuting data, speeds up processing time considerably. The results of the Intramax analysis are evaluated with travel-to-work area constraints, and comparisons are made with commuting fields, accessibility to employment, commuting flow density and network commuting flow size. From selected steps in the regionalization process, a hierarchy of nested commuting regions emerges, revealing the complexity of commuting patterns.

Mapping Attribution Metadata to the Open Provenance Model

A description of a data item's provenance can be provided in dierent forms, and which form is best depends on the intended use of that description. Because of this, dierent communities have made quite distinct underlying assumptions in their models for electronically representing provenance. Approaches deriving from the library and archiving communities emphasise agreed vocabulary by which resources can be described and, in particular, assert their attribution (who created the resource, who modied it, where it was stored etc.) The primary purpose here is to provide intuitive metadata by which users can search for and index resources. In comparison, models for representing the results of scientific workflows have been developed with the assumption that each event or piece of intermediary data in a process' execution can and should be documented, to give a full account of the experiment undertaken. These occurrences are connected together by stating where one derived from, triggered, or otherwise caused another, and so form a causal graph. Mapping between the two approaches would be benecial in integrating systems and exploiting the strengths of each. In this paper, we specify such a mapping between Dublin Core and the Open Provenance Model. We further explain the technical issues to overcome and the rationale behind the approach, to allow the same method to apply in mapping similar schemes.

A Resource Centric Approach For Advancing Collaboration Through Hydrologic Data And Model Sharing

HydroShare is an online, collaborative system being developed for open sharing of hydrologic data and models. The goal of HydroShare is to enable scientists to easily discover and access hydrologic data and models, retrieve them to their desktop or perform analyses in a distributed computing environment that may include grid, cloud or high performance computing model instances as necessary. Scientists may also publish outcomes (data, results or models) into HydroShare, using the system as a collaboration platform for sharing data, models and analyses. HydroShare is expanding the data sharing capability of the CUAHSI Hydrologic Information System by broadening the classes of data accommodated, creating new capability to share models and model components, and taking advantage of emerging social media functionality to enhance information about and collaboration around hydrologic data and models. One of the fundamental concepts in HydroShare is that of a Resource. All content is represented using a Resource Data Model that separates system and science metadata and has elements common to all resources as well as elements specific to the types of resources HydroShare will support. These will include different data types used in the hydrology community and models and workflows that require metadata on execution functionality. The HydroShare web interface and social media functions are being developed using the Drupal content management system. A geospatial visualization and analysis component enables searching, visualizing, and analyzing geographic datasets. The integrated Rule-Oriented Data System (iRODS) is being used to manage federated data content and perform rule-based background actions on data and model resources, including parsing to generate metadata catalog information and the execution of models and workflows. This presentation will introduce the HydroShare functionality developed to date, describe key elements of the Resource Data Model and outline the roadmap for future development.

Verification Of The Standard Vector Data Model For Interoperability Of River-Geospatial Information

Recently, two international standard organizations, ISO and OGC, have done the work of standardization for GIS. Current standardization work for providing interoperability among GIS DB focuses on the design of open interfaces. But, this work has not considered procedures and methods for designing river geospatial data. Eventually, river geospatial data has its own model. When we share the data by open interface among heterogeneous GIS DB, differences between models result in the loss of information. In this study a plan was suggested both to respond to these changes in the information envirnment and to provide a future Smart River-based river information service by understanding the current state of river geospatial data model, improving, redesigning the database. Therefore, primary and foreign key, which can distinguish attribute information and entity linkages, were redefined to increase the usability. Database construction of attribute information and entity relationship diagram have been newly redefined to redesign linkages among tables from the perspective of a river standard database. In addition, this study was undertaken to expand the current supplier-oriented operating system to a demand-oriented operating system by establishing an efficient management of river-related information and a utilization system, capable of adapting to the changes of a river management paradigm.

Desenvolvimento e implantação de Data Base Marketing para apoiar estratégia de gestão de fidelização de clientes em empresa administradora de consórcios

o ambiente econômico atual tem exigido empenho das empresas em conhecer, interagir, diferenciar e personalizar cada vez mais produtos e serviços para os clientes. Este cenário requer ferramentas e modelos de gestão para gerenciar as relações com os clientes, com o objetivo de permitir que a empresa consiga perceber e responder rapidamente a exigências dos consumidores. Este trabalho revisa conceitos de CRM (Customer Relationschip Management ou Gerenciamento das Relações com os Clientes) e descreve a implementação de ferramenta de gestão de relacionamento com clientes em empresa de consórcio. O desenvolvimento do trabalho reflete uma necessidade apontada no planejamento estratégico da empresa, sendo que ferramentas de tecnologia de informação e software de banco de dados foram usadas como suporte aos propósitos da gestão empresarial. Como resultado do trabalho, a empresa está hoje atuando com um sistema de Data Base Marketing, o qual foi criado para auxiliar os profissionais envolvidos no processo de atendimento e gestão de relacionamento com clientes. O Data Base Marketing esta sendo utilizado para coletar dados de atendimento a clientes, tais como históricos de atendimento, dados cadastrais, perfil demográfico, perfil psicográfico e categoria de valor dos clientes. Durante o processo de interação com clientes, o sistema facilita o trabalho dos especialistas e permite melhorar a qualidade do atendimento aos clientes, contemplando necessidades dos diversos especialistas da empresa em assuntos como vendas, qualidade em serviços, finanças e gestão empresarial.O processo começou pela constituição de um grupo de trabalho interno para discutir estratégias e cronograma de implantação. A primeira decisão do grupo foi pelo desenvolvimento interno do software visando atender plenamente o "core business" da empresa. O processo começou pela constituição de um grupo de trabalho interno para discutir estratégias e cronograma de implantação. A primeira decisão do grupo foi pelo desenvolvimento interno do software visando atender plenamente o "core business" da empresa. O projeto contou com o conhecimento do negócio dos profissionais da empresa e auxilio de especialistas e consultores externos. O detalhamento do projeto, bem como os passos da pesquisa-ação, está descrito no corpo da dissertação.

Data Mining no Varejo: estudo de caso para loja de materiais de construção

Este trabalho apresenta um estudo de caso de mineração de dados no varejo. O negócio em questão é a comercialização de móveis e materiais de construção. A mineração foi realizada sobre informações geradas das transações de vendas por um período de 8 meses. Informações cadastrais de clientes também foram usadas e cruzadas com informações de venda, visando obter resultados que possam ser convertidos em ações que, por conseqüência, gerem lucro para a empresa. Toda a modelagem, preparação e transformação dos dados, foi feita visando facilitar a aplicação das técnicas de mineração que as ferramentas de mineração de dados proporcionam para a descoberta de conhecimento. O processo foi detalhado para uma melhor compreensão dos resultados obtidos. A metodologia CRISP usada no trabalho também é discutida, levando-se em conta as dificuldades e facilidades que se apresentaram durante as fases do processo de obtenção dos resultados. Também são analisados os pontos positivos e negativos das ferramentas de mineração utilizadas, o IBM Intelligent Miner e o WEKA - Waikato Environment for Knowledge Analysis, bem como de todos os outros softwares necessários para a realização do trabalho. Ao final, os resultados obtidos são apresentados e discutidos, sendo também apresentada a opinião dos proprietários da empresa sobre tais resultados e qual valor cada um deles poderá agregar ao negócio.

Modelo de gerenciamento de versões para evolução de Data Warehouses

Sistemas de tomada de decisão baseados em Data Warehouse (DW) estão sendo cada dia mais utilizados por grandes empresas e organizações. O modelo multidimensional de organização dos dados utilizado por estes sistemas, juntamente com as técnicas de processamento analítico on-line (OLAP), permitem análises complexas sobre o histórico dos negócios através de uma simples e intuitiva interface de consulta. Apesar dos DWs armazenarem dados históricos por natureza, as estruturas de organização e classificação destes dados, chamadas de dimensões, não possuem a rigor uma representação temporal, refletindo somente a estrutura corrente. Para um sistema destinado à análise de dados, a falta do histórico das dimensões impossibilita consultas sobre o ambiente real de contextualização dos dados passados. Além disso, as alterações dos esquemas multidimensionais precisam ser assistidas e gerenciadas por um modelo de evolução, de forma a garantir a consistência e integridade do modelo multidimensional sem a perda de informações relevantes. Neste trabalho são apresentadas dezessete operações de alteração de esquema e sete operações de alteração de instâncias para modelos multidimensionais de DW. Um modelo de versões, baseado na associação de intervalos de validade aos esquemas e instâncias, é proposto para o gerenciamento dessas operações. Todo o histórico de definições e de dados do DW é mantido por esse modelo, permitindo análises completas dos dados passados e da evolução do DW. Além de suportar consultas históricas sobre as definições e as instâncias do DW, o modelo também permite a manutenção de mais de um esquema ativo simultaneamente. Isto é, dois ou mais esquemas podem continuar a ter seus dados atualizados periodicamente, permitindo assim que as aplicações possam consultar dados recentes utilizando diferentes versões de esquema.

Export-led recoveries in small open industrialized economies

This paper studies the role of Vertical Specialization-based trade and foreign damand push as elements capable of explaining export-led recoveries in small open industrialized economies. The empirical evidence on export-led recoveries is reviewed. Data supporting the growing importance of vertical specialization for international trade are presented. I compare the performance of two versions of a small open economy model, calibrated to mimic Canadian Business Cycles. The …rst one is based upon Schmitt-Grohe(1998). The second incorporates Vertical- Specialization-based trade. I show that an arti…cial economy featuring Vertical-Specializationbased trade in conjunction with an exogenous AR(2) process for foreign output displays improved impulse responses to a foreign output shock and is able to mimic the contribution of Canadian exports to output growth during economic recoveries.

Photosynthesis induction in Eucalyptus urograndis seedlings and cuttings measured by Open Photoacoustics

In this work we study the photosynthetic induction in Eucalyptus urograndis leaves using the Open Photoacoustic Cell Technique. In vivo and in situ measurements were performed in leaves of four months-old E. urograndis seedlings and C041 cuttings previously dark-adapted for at least 10 h. Experimental results for the gas exchange component of the photoacoustic (PA) signal are interpreted considering that a gas uptake component would have a phase angle nearly opposite to that of the oxygen evolution component. Analysis of the photosynthetic induction data shows that seedlings present a net oxygen evolution before cuttings, but cuttings reach a higher steady-state photosynthetic activity.

HTRIdb: an open-access database for experimentally verified human transcriptional regulation interactions

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)