Escuela en Hunstanton de A+P Smithson: el Nuevo Brutalismo en Inglaterra

La tesis estudia en detalle la Hunstanton Secondary School y su trascendencia. Así, se trata de analizar el conjunto de procesos que hace que esta obra sea entendida como el manifiesto construido del Nuevo Brutalismo en Inglaterra. La Escuela en Hunstanton fue la primera obra proyectada y construida por los Smithson y, si se considera que el legado que dejaron Alison y Peter fue más de carácter teórico que constructivo, ésta se ha convertido en un edificio relevante dentro de su trayectoria profesional. Además, el rigor con el que fue realizado el proyecto y la ratificación de las ideas que subyacían tras él, a pesar del extenso intervalo temporal que caracterizó su proceso constructivo, hacen que esta obra se convierta en una síntesis de la filosofía arquitectónica gestada en Inglaterra tras la guerra. Por otro lado, hay que contemplar que la sencillez del lenguaje constructivo empleado, viene dada por la compleja reiteración de los sistemas proyectuales tipo que formulan para este proyecto y el establecimiento de una gramática casi matemática. La sistematización de su vocabulario hace que, tras el análisis de su arquitectura, se encuentren nuevos parámetros capaces de documentar este momento de la historia de la arquitectura en Inglaterra. La envolvente del edificio constituye al tiempo fachada y estructura. Esta característica ha pasado inadvertida cuando, en numerosas ocasiones y durante seis décadas, se han venido publicando las fotografías de la obra terminada y los dibujos que los Smithson habían realizado en la fase de proyecto. Como consecuencia, ha proliferado el conocimiento de la arquitectura de la escuela a un nivel más superficial, mostrando el resultado formal de la misma y con ello, simplemente se ha dejado intuir la gran influencia que Mies Van der Rohe provocó en los Smithson en los primeros años de desarrollo de su labor como arquitectos. El objetivo principal de esta tesis es, por tanto, facilitar el entendimiento del espacio que propusieron los Smithson a partir del análisis pormenorizado de los distintos sistemas constructivos empleados y del equipo personal que se vio implicado en su construcción. Para ello, es necesario abordar el estudio de los materiales y mecanismos proyectuales que hicieron posible que este conjunto de espacios –interiores y exteriores- resultase definido a través de la relación entre dos variables: una evidente austeridad en la utilización de los materiales y la combinación de los distintos sistemas intervinientes a partir del recurso de la repetición. La Escuela de Hunstanton, a pesar de las inoportunas intervenciones realizadas para adaptar el centro a unas necesidades derivadas de su número de alumnos actual (el doble que en su inicio), continúa proclamando su integridad espacial. Partiendo de la hipótesis de que la arquitectura de la Secondary School en Hunstanton, representa el manifiesto construido del Nuevo Brutalismo en Inglaterra, se concluye que el resultado de su construcción fue consecuencia de numerosas influencias que, en relación con los Smithson, estuvieron presentes durante los años en que se gestó. Algo que va más allá de la conclusión de aquellos debates arquitectónicos que se habían emprendido, por escrito, en las distintas revistas locales de arquitectura. Los mecanismos compositivos empleados, también habían tenido mucho que ver con lo que los historiadores del arte habían venido aportando a la historia de la arquitectura hasta ese momento. Desde los años 40, éstos últimos habían emprendido una nueva manera de contar la historia en la que quedaba fuertemente involucrada su capacidad crítica, provocando interferencias en la mentalidad de los arquitectos de nueva generación y otorgándoles un bagaje cultural subliminalmente determinado y subjetivo. Por supuesto, en el resultado arquitectónico final, también tuvieron mucho que ver los recursos materiales de que se disponía en aquel momento. Así como la optimización de los mismos a través de la adopción de nuevas metodologías de trabajo como puede ser la organización multidisciplinar. La inclusión del ingeniero Ronald Jenkins en el equipo de trabajo de los Smithson supuso una gran oportunidad. Este ingeniero, propuso poner en práctica la entonces innovadora Teoría Plástica en la metodología de cálculo estructural y, con ello consiguió enriquecer el resultado espacial, posibilitando la percepción de una arquitectura ligera –a pesar de sus grandes dimensiones- y vinculada al paisaje donde se inserta. Pero todos estos condicionantes fueron pasados a su vez por el filtro del deseo de una regeneración social, que buscaba el modelo de la sociedad americana. El Buen Vivir que propugnaban los americanos, viajaba a Europa de la mano de la publicidad. Y, al igual que la componente publicitaria tuvo algo que ver en el proceso creativo de la arquitectura de la escuela, también lo tuvo el conocimiento del arte pop y sus recursos compositivos. ABSTRACT The thesis examines in detail the project of Hunstanton Secondary School and the architectural language’s significance used in it. Thus, it is reinterpreting the set of processes that makes this work to be understood as the “built manifesto” of the English New Brutalism. Hunstanton School’s project was the first work designed and built by the Smithsons and, considering their legacy -more theoretical than constructed-, make of this building an important work within their career. In addition, the rigor with which it was carried out the project and the ratification of the ideas lying behind him, make this work becomes a synthesis of the architectural philosophy gestated in England after the war, despite the extensive time interval that characterized its construction process. On the other hand, it must be considered the simplicity of the constructive language used in this project. It is given by the complex projective repetition of the type systems and by the establishment of a quasi-mathematical grammar. The systematization of its vocabulary makes, after a deep analysis of its architecture, to recognize new parameters able to document this moment in the history of English architecture. The building envelope is, at the same time, facade and structure. This feature has been overlooked when many photographs of the finished work and its drawings -made by the Smithsons during the design phase- has been exposed over six decades. As a result, it has proliferated the knowledge of Hunstanton Secondary Modern School’s architecture as a more superficial level, just by showing the formal outcome of its project and thus simply been left the sensation of the great influence that Mies Van der Rohe provocated in the Smithson thinking during their first years of developing his work as architects. Therefore, the main objective of this thesis is to facilitate an understanding of the Smithsons’ proposed space. This is made possible through the detailed analysis of the different systems used in it and, by understanding the knowledge of the team involved in its construction. To prove this, it is necessary to pay attention to the study of the materials and to different project mechanisms that make possible to this group of spaces -inner and outer- be defined through the game played by two variables: an apparent austerity in the use of materials and the combination of the various participant systems through the resource of repetition. Despite the untimely interventions made in order to adapt the center to the new needs (the large increase in the number of students), Hunstanton School’s building continues proclaiming its spatial integrity. Assuming that Hunstanton Secondary School’s architecture represents the manifesto of New Brutalism in England, it is concluded that the result of its construction was the result of numerous influences that, in connection with the Smithsons, were present during the years in which its project was conceived. This meaning goes beyond the conclusions made from the architectural debate that was published in many of local architectural magazines. The compositional mechanisms employed, are also linked to what art historians had contributed to the history of architecture until then. Since the 40s, historians had undertaken a new way to tell History. This new mode strongly implied its critical capacity. All this, was causing interferences in the mentality of the architects of the new generation and, giving them a subliminally determined and very subjective cultural background. Of course, the final architectural result had much to do with the material resources available at that time and, with its optimization through the adoption of new working methods as the multidisciplinary organization. The inclusion of engineer Ronald Jenkins in the team of the Smithsons was a great opportunity. He proposed to implement the new Plastic Theory in the structural calculation and thereby he got enrich the spatial results achieved, by enabling the perception of a lightweight construction, despite its large size and, linked to the landscape where it is inserted. But all these conditions were passed through the filter of social regeneration’s desire, following the American society’s model. This American model travelled to Europe in the hands of advertising. And, in the same way that publicity had something to do with the creative process of this architecture, also had a lot to do the knowledge of pop art and its compositional resources.

ESPERANÇAS E DECEPÇÕES Uma análise crítica da Prática Pastoral do neopentecostalismo na Igreja Internacional da Graça de Deus sob a perspectiva da Práxis Religiosa

O texto analisa a prática pastoral do neopentecostalismo na Igreja Internacional da Graça de Deus. Esta Igreja expandiu-se substancialmente no Brasil, conseguiu arregimentar um número enorme de seguidores e conquistou expressiva visibilidade na mídia. A pesquisa estuda a trajetória histórica do neopentecostalismo, o seu desenvolvimento no Brasil e os aspectos teológicos do movimento. Estuda-se também a Igreja da Graça, sua origem, sua teologia, sua estrutura de governo, seu ministério pastoral e expansão. Por estar inserida dentro do neopentecostalismo, a Igreja da Graça reflete também a sua teologia, que propõe banir a doença, a pobreza e todo o tipo de sofrimento da vida humana, a fim de produzir uma nova geração de fiéis: ricos e saudáveis. De acordo com a sua teologia, o cristão deve viver todo o tempo de sua vida livre de qualquer aspecto negativo da existência humana. Se isso não acontece, é porque ele não tem fé, está sob o poder de Satã ou tem um comportamento que desagrada a Deus. Assim, a marca do verdadeiro cristão é a plena saúde física e emocional, além da prosperidade financeira. Entretanto, a pregação neopentecostal tem produzido desapontamentos, principalmente, quando a cura física não acontece e o dinheiro não aparece. Portanto, esta tese formula uma proposta de prática pastoral de esperança que possibilite aos decepcionados com essa mensagem triunfalista retomarem a vida cristã dentro do seu espaço cristão.(AU)

ESPERANÇAS E DECEPÇÕES Uma análise crítica da Prática Pastoral do neopentecostalismo na Igreja Internacional da Graça de Deus sob a perspectiva da Práxis Religiosa

O texto analisa a prática pastoral do neopentecostalismo na Igreja Internacional da Graça de Deus. Esta Igreja expandiu-se substancialmente no Brasil, conseguiu arregimentar um número enorme de seguidores e conquistou expressiva visibilidade na mídia. A pesquisa estuda a trajetória histórica do neopentecostalismo, o seu desenvolvimento no Brasil e os aspectos teológicos do movimento. Estuda-se também a Igreja da Graça, sua origem, sua teologia, sua estrutura de governo, seu ministério pastoral e expansão. Por estar inserida dentro do neopentecostalismo, a Igreja da Graça reflete também a sua teologia, que propõe banir a doença, a pobreza e todo o tipo de sofrimento da vida humana, a fim de produzir uma nova geração de fiéis: ricos e saudáveis. De acordo com a sua teologia, o cristão deve viver todo o tempo de sua vida livre de qualquer aspecto negativo da existência humana. Se isso não acontece, é porque ele não tem fé, está sob o poder de Satã ou tem um comportamento que desagrada a Deus. Assim, a marca do verdadeiro cristão é a plena saúde física e emocional, além da prosperidade financeira. Entretanto, a pregação neopentecostal tem produzido desapontamentos, principalmente, quando a cura física não acontece e o dinheiro não aparece. Portanto, esta tese formula uma proposta de prática pastoral de esperança que possibilite aos decepcionados com essa mensagem triunfalista retomarem a vida cristã dentro do seu espaço cristão.(AU)

Noncytopathic Sindbis virus RNA vectors for heterologous gene expression

Infection of vertebrate cells with alphaviruses normally leads to prodigious expression of virus-encoded genes and a dramatic inhibition of host protein synthesis. Recombinant Sindbis viruses and replicons have been useful as vectors for high level foreign gene expression, but the cytopathic effects of viral replication have limited their use to transient studies. We recently selected Sindbis replicons capable of persistent, noncytopathic growth in BHK cells and describe here a new generation of Sindbis vectors useful for long-term foreign gene expression based on such replicons. Foreign genes of interest as well as the dominant selectable marker puromycin N-acteyltransferase, which confers resistance to the drug puromycin, were expressed as subgenomic transcripts of noncytopathic replicons or defective-interfering genomes complemented in trans by a replicon. Based on these strategies, we developed vectors that can be initiated via either RNA or DNA transfection and analyzed them for their level and stability of foreign gene expression. Noncytopathic Sindbis vectors express reasonably high levels of protein in nearly every cell. These vectors should prove to be flexible tools for the rapid expression of heterologous genes under conditions in which cellular metabolism is not perturbed, and we illustrate their utility with a number of foreign proteins.

Metabolic pathway engineering in cotton: Biosynthesis of polyhydroxybutyrate in fiber cells

Alcaligenes eutrophus genes encoding the enzymes, β-ketothiolase (phaA), acetoacetyl-CoA reductase (phaB), and polyhydroxyalkanoate synthase (phaC) catalyze the production of aliphatic polyester poly-d-(−)-3-hydroxybutyrate (PHB) from acetyl-CoA. PHB is a thermoplastic polymer that may modify fiber properties when synthesized in cotton. Endogenous β-ketothiolase activity is present in cotton fibers. Hence cotton was transformed with engineered phaB and phaC genes by particle bombardment, and transgenic plants were selected based on marker gene, β-glucuronidase (GUS), expression. Fibers of 10 transgenic plants expressed phaB gene, while eight plants expressed both phaB and phaC genes. Electron microscopy examination of fibers expressing both genes indicated the presence of electron-lucent granules in the cytoplasm. High pressure liquid chromatography, gas chromatography, and mass spectrometry evidence suggested that the new polymer produced in transgenic fibers is PHB. Sixty-six percent of the PHB in fibers is in the molecular mass range of 0.6 × 106 to 1.8 × 106 Da. The presence of PHB granules in transgenic fibers resulted in measurable changes of thermal properties. The fibers exhibited better insulating characteristics. The rate of heat uptake and cooling was slower in transgenic fibers, resulting in higher heat capacity. These data show that metabolic pathway engineering in cotton may enhance fiber properties by incorporating new traits from other genetic sources. This is an important step toward producing new generation fibers for the textile industry.

Very large radio surveys of the sky

Recent advances in electronics and computing have made possible a new generation of large radio surveys of the sky that yield an order-of-magnitude higher sensitivity and positional accuracy. Combined with the unique properties of the radio universe, these quantitative improvements open up qualitatively different and exciting new scientific applications of radio surveys.

Synthetic transcripts of double-stranded Birnavirus genome are infectious.

We have developed a system for generation of infectious bursal disease virus (IBDV), a segmented double-stranded RNA virus of the Birnaviridae family, with the use of synthetic transcripts derived from cloned cDNA. Independent full-length cDNA clones were constructed that contained the entire coding and noncoding regions of RNA segments A and B of two distinguishable IBDV strains of serotype I. Segment A encodes all of the structural (VP2, VP4, and VP3) and nonstructural (VP5) proteins, whereas segment B encodes the RNA-dependent RNA polymerase (VP1). Synthetic RNAs of both segments were produced by in vitro transcription of linearized plasmids with T7 RNA polymerase. Transfection of Vero cells with combined plus-sense transcripts of both segments generated infectious virus as early as 36 hr after transfection. The infectivity and specificity of the recovered chimeric virus was ascertained by the appearance of cytopathic effect in chicken embryo cells, by immunofluorescence staining of infected Vero cells with rabbit anti-IBDV serum, and by nucleotide sequence analysis of the recovered virus, respectively. In addition, transfectant viruses containing genetically tagged sequences in either segment A or segment B of IBDV were generated to confirm the feasibility of this system. The development of a reverse genetics system for double-stranded RNA viruses will greatly facilitate studies of the regulation of viral gene expression, pathogenesis, and design of a new generation of live vaccines.

Eradication of large colon tumor xenografts by targeted delivery of maytansinoids.

The maytansinoid drug DM1 is 100- to 1000-fold more cytotoxic than anticancer drugs that are currently in clinical use. The immunoconjugate C242-DM1 was prepared by conjugating DM1 to the monoclonal antibody C242, which recognizes a mucin-type glycoprotein expressed to various extents by human colorectal cancers. C242-DM1 was found to be highly cytotoxic toward cultured colon cancer cells in an antigen-specific manner and showed remarkable antitumor efficacy in vivo. C242-DM1 cured mice bearing subcutaneous COLO 205 human colon tumor xenografts (tumor size at time of treatment 65-130 mm3), at doses that showed very little toxicity and were well below the maximum tolerated dose. C242-DM1 could even effect complete regressions or cures in animals with large (260- to 500-mm3) COLO 205 tumor xenografts. Further, C242-DM1 induced complete regressions of subcutaneous LoVo and HT-29 colon tumor xenografts that express the target antigen in a heterogeneous manner. C242-DM1 represents a new generation of immunoconjugates that may yet fulfill the promise of effective cancer therapy through antibody targeting of cytotoxic agents.

Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.

Matrix metalloproteinase enzymes have been implicated in degenerative processes like tumor cell invasion, metastasis, and arthritis. Specific metalloproteinase inhibitors have been used to block tumor cell proliferation. We have examined the interaction of batimastat (BB-94) with a metalloproteinase [atrolysin C (Ht-d), EC 3.4.24.42] active site at 2.0-angstroms resolution (R = 16.8%). The title structure exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. This unprecedented binding geometry dramatizes the significance of the cavernous primary specificity site, pointing the way for the design of a new generation of potential antitumor drugs.

bioNMF: a versatile tool for non-negative matrix factorization in biology

Medical imaging has become an absolutely essential diagnostic tool for clinical practices; at present, pathologies can be detected with an earliness never before known. Its use has not only been relegated to the field of radiology but also, increasingly, to computer-based imaging processes prior to surgery. Motion analysis, in particular, plays an important role in analyzing activities or behaviors of live objects in medicine. This short paper presents several low-cost hardware implementation approaches for the new generation of tablets and/or smartphones for estimating motion compensation and segmentation in medical images. These systems have been optimized for breast cancer diagnosis using magnetic resonance imaging technology with several advantages over traditional X-ray mammography, for example, obtaining patient information during a short period. This paper also addresses the challenge of offering a medical tool that runs on widespread portable devices, both on tablets and/or smartphones to aid in patient diagnostics.

Aplicações híbridas entre sistemas multiagentes e técnicas de inteligência artificial para redes inteligentes de distribuição de energia elétrica

Os smart grids representam a nova geração dos sistemas elétricos de potência, combinando avanços em computação, sistemas de comunicação, processos distribuídos e inteligência artificial para prover novas funcionalidades quanto ao acompanhamento em tempo real da demanda e do consumo de energia elétrica, gerenciamento em larga escala de geradores distribuídos, entre outras, a partir de um sistema de controle distribuído sobre a rede elétrica. Esta estrutura modifica profundamente a maneira como se realiza o planejamento e a operação de sistemas elétricos nos dias de hoje, em especial os de distribuição, e há interessantes possibilidades de pesquisa e desenvolvimento possibilitada pela busca da implementação destas funcionalidades. Com esse cenário em vista, o presente trabalho utiliza uma abordagem baseada no uso de sistemas multiagentes para simular esse tipo de sistema de distribuição de energia elétrica, considerando opções de controle distintas. A utilização da tecnologia de sistemas multiagentes para a simulação é baseada na conceituação de smart grids como um sistema distribuído, algo também realizado nesse trabalho. Para validar a proposta, foram simuladas três funcionalidades esperadas dessas redes elétricas: classificação de cargas não-lineares; gerenciamento de perfil de tensão; e reconfiguração topológica com a finalidade de reduzir as perdas elétricas. Todas as modelagens e desenvolvimentos destes estudos estão aqui relatados. Por fim, o trabalho se propõe a identificar os sistemas multiagentes como uma tecnologia a ser empregada tanto para a pesquisa, quanto para implementação dessas redes elétricas.

Ianus: an adaptive FPGA computer

Dedicated machines designed for specific computational algorithms can outperform conventional computers by several orders of magnitude. In this note we describe Ianus, a new generation FPGA based machine and its basic features: hardware integration and wide reprogrammability. Our goal is to build a machine that can fully exploit the performance potential of new generation FPGA devices. We also plan a software platform which simplifies its programming, in order to extend its intended range of application to a wide class of interesting and computationally demanding problems. The decision to develop a dedicated processor is a complex one, involving careful assessment of its performance lead, during its expected lifetime, over traditional computers, taking into account their performance increase, as predicted by Moore’s law. We discuss this point in detail.

Onsite Wastewater Model Performance Code Implementation Plan

As the population of Colorado continues to grow, the impacts from individual sewage disposal systems, or onsite wastewater systems (OWS), are becoming more apparent. Increased use of OWS impacts not only water quality but land use and development as well. These impacts have led to the need for a new generation of wastewater regulations in the state, a transition from the historic prescriptive requirements to a more progressive, performance-based system. A performance-based system will allow smarter growth, improved water quality, and cost savings for both the regulatory agencies and the OWS industry in Colorado. This project outlines the challenges and essential elements required to make this transition, and provides guidance on how to meet the challenges and overcome barriers to implementing a performance code in Colorado.

TEXT-MESS: Intelligent, Interactive and Multilingual Text Mining based on Human Language Technologies, TIN2006-15265-C06

The goal of the project is to analyze, experiment, and develop intelligent, interactive and multilingual Text Mining technologies, as a key element of the next generation of search engines, systems with the capacity to find "the need behind the query". This new generation will provide specialized services and interfaces according to the search domain and type of information needed. Moreover, it will integrate textual search (websites) and multimedia search (images, audio, video), it will be able to find and organize information, rather than generating ranked lists of websites.

A Survey on FPGA-Based Sensor Systems: Towards Intelligent and Reconfigurable Low-Power Sensors for Computer Vision, Control and Signal Processing

The current trend in the evolution of sensor systems seeks ways to provide more accuracy and resolution, while at the same time decreasing the size and power consumption. The use of Field Programmable Gate Arrays (FPGAs) provides specific reprogrammable hardware technology that can be properly exploited to obtain a reconfigurable sensor system. This adaptation capability enables the implementation of complex applications using the partial reconfigurability at a very low-power consumption. For highly demanding tasks FPGAs have been favored due to the high efficiency provided by their architectural flexibility (parallelism, on-chip memory, etc.), reconfigurability and superb performance in the development of algorithms. FPGAs have improved the performance of sensor systems and have triggered a clear increase in their use in new fields of application. A new generation of smarter, reconfigurable and lower power consumption sensors is being developed in Spain based on FPGAs. In this paper, a review of these developments is presented, describing as well the FPGA technologies employed by the different research groups and providing an overview of future research within this field.