Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells

Cells with impaired transporter associated with antigen processing (TAP) function express low levels of cell surface major histocompatibility complex (MHC) class I molecules, and are generally resistant to lysis by MHC class I restricted cytotoxic T lymphocytes (CTLs). Here we report the generation of MHC class I restricted CD8+ CTLs that surprisingly require target cell TAP deficiency for efficient recognition. C57BL/6 (B6) mice immunized with syngenic B7–1 (CD80) expressing TAP-deficient cells generated a potent CTL response against both TAP-deficient RMA-S tumor cells and TAP-deficient Con A blasts, whereas the corresponding TAP-expressing target cells were considerably less susceptible or resistant to lysis. The CTL epitopes recognized were expressed also by the human TAP-deficient cell line T2, transfected with appropriate MHC class I molecules. B6 mice immunized with B7–1-transfected TAP-deficient RMA-S cells were protected from outgrowth of a subsequent RMA-S tumor challenge. These findings are discussed in relation to the biochemical nature of MHC class I dependent CTL epitopes associated with impaired TAP function, as well as implications for immunotherapy and autoimmunity.

Open randomised study of use of levonorgestrel releasing intrauterine system as alternative to hysterectomy

Objectives: To assess whether the levonorgestrel intrauterine system could provide a conservative alternative to hysterectomy in the treatment of excessive uterine bleeding.

Late-Holocene Mass Movements in High Arctic East Lake, Melville Island (Western Canadian Arctic Archipelago)

East Lake, located at Cape Bounty (Melville Island, Canadian High Arctic), was mapped using a high-resolution swath bathymetric sonar and a 12 kHz sub-bottom profiler, allowing for the first time the imaging of widespread occurrence of mass movement deposits (MMDs) in a Canadian High Arctic Lake. Mass movements occurred mostly on steep slopes located away from deltaic sedimentation. The marine to lacustrine transition in the sediment favours the generation of mass movements where the underlying massive mud appears to act as a gliding surface for the overlying varved deposits. Based on acoustic stratigraphy, we have identified at least two distinct events that triggered failures in the lake during the last 2000 years. The synchronicity of multiple failures and their widespread distribution suggest a seismic origin that could be related to the nearby Gustaf-Lougheed Arch seismic zone. Further sedimentological investigations on the MMDs are however required to confirm their age and origin.

(Table 19, page 199) Minor constituents of one of the San Clemente iron concretions and its metallic core

The chemical and mineralogical composition of pelagic sediments from the East Pacific Ocean has been determined with the aim of defining the ultimate sources and the mechanisms of formation of the solid phases. The distribution of elements between sea-water, the pore solution and the various solid components of the sediments permits interpretations of the variations in time and space of the gross chemical composition of pelagic clays. For example, manganese, present in sea-water in a divalent form, is apparently oxidized at the sediment-water interface to tetravalent species which subsequently become a part of the group of ferromanganese oxide minerals which are found in the marine environment. It is suggested the rate of manganese accumulation in sediments is some function of the length of time the sediment surface is in contact with sea-water. The contribution of chemical species from the different geospheres is considered. The quantitative importance of pelagic clays in the major sedimentary cycle is studied on the basis of the distribution of the weathered igneous rock products between continental and pelagic deposits and sea-water. These analyses of a wide variety of pelagic clays allow a reformulation of the geochemical balance and it is concluded that pelagic clays account for approximately 13 per cent of the total mass of sediments produced over geologic time.

Oma maa : tietokirja suomen kodeille /

v.1. Tammikuu-Helmikuu -- v.2. Maaliskuu-Huhtikuu -- v.3. Toukokuu-Kesäkuu -- v.4. Heinäkuu-Elokuu -- v.5. Syyskuu-Lokakuu -- v.6. Marraskuu-Joulukuu.

Schwedische Volkslieder der Vorzeit /

Mode of access: Internet.

Betänkande angående gemensamt lönesystem samt lönereglering för postverket : telegrafverket, statens järnvägar och statens vattenfallsverk avgivet enligt det av Kungl. Maj: t den 28 juni 1918 lämnade uppdrag.

C. Ekman, ordförande; A. Hamilton, sekreterare.

Arbitration between the United States and Sweden under special agreement of December 17, 1930.

Parts 3 and 4, "Photographic reprint".

Sveriges bibliografi, 1481-1600. : Band I ... 1481-1530 /

Two volumes in continuation and a new edition of this first volume were published by Isak Collijn (Uppsala, 1927-38) with title: Sveriges bibliografi intill ȧr 1600.

The psychological basis of phonetic law and analogy.

"Reprinted from the Publications of the Modern language association of America, vol. IX, no. 2."

Sanningen om kriget. En framställning efter officiella källor.

"Utgifvare: Paul Dehn ... d:r Drechsler ... Matthias Erzberger [o.a.]"

Konungariket Sveriges statistik i sammandrag.

Mode of access: Internet.

Svenska folkvisor /

Melodies with piano.

Bibliotheca historica sueo-gothica, af C.G. Warmholtz. 1782-9.

Preface signed: Aksel Andersson.