Die Schächtfrage vor der bayerischen Volksvertretung

von Friedr. Frank

Dissertatiuncula de genuina ratione, quare de legibus mosaicis matrimonialibus dispensari nequeat

ed. a Georg. Fried. a Zanthier

Vollständiges hebräisch-chaldäisch-rabbinisches Wörterbuch über das Alte Testament, die Thargumim, Midraschim und den Talmud, mit Erläuterungen aus dem Bereiche der historischen Kritik, Archäologie, Mythologie, Naturkunde etc. und mit bes. Berücksichtigung der Dieta messiana, als Bindemittel der Schriften des alten und neuen Bundes

von Fr. Nork

Die Schächtfrage vor der bayerischen Volksvertretung

von Friedr. Frank

Neue Eidesverwarnungen zum Gebrauch in Gerichten

von Georg Friedrich Seiler

Evaluation of colon cancer histomorphology: a comparison between formalin and PAXgene tissue fixation by an international ring trial.

The aim of our study was to evaluate the quality of histo- and cytomorphological features of PAXgene-fixed specimens and their suitability for histomorphological classification in comparison to standard formalin fixation. Fifteen colon cancer tissues were collected, divided into two mirrored samples and either formalin fixed (FFPE) or PAXgene fixed (PFPE) before paraffin embedding. HE- and PAS-stained sections were scanned and evaluated in a blinded, randomised ring trial by 20 pathologists from Europe and the USA using virtual microscopy. The pathologists evaluated histological grading, histological subtype, presence of adenoma, presence of lymphovascular invasion, quality of histomorphology and quality of nuclear features. Statistical analysis revealed that the reproducibility with regard to grading between both fixation methods was rather satisfactory (weighted kappa statistic (k w) = 0.73 (95 % confidence interval (CI), 0.41-0.94)), with a higher agreement between the reference evaluation and the PFPE samples (k w = 0.86 (95 % CI, 0.67-1.00)). Independent from preservation method, inter-observer reproducibility was not completely satisfactory (k w = 0.60). Histomorphological quality parameters were scored equal or better for PFPE than for FFPE samples. For example, overall quality and nuclear features, especially the detection of mitosis, were judged significantly better for PFPE cases. By contrast, significant retraction artefacts were observed more frequently in PFPE samples. In conclusion, our findings suggest that the PAXgene Tissue System leads to excellent preservation of histomorphology and nuclear features of colon cancer tissue and allows routine morphological diagnosis.

Die Juden im Preußischen Staate : eine geschichtl. Darstellung d. politischen, bürgerl. u. privatrechtl. Verhältnisse d. Juden in Preußen, nach d. verschiedenen Landesteilen

von C. F. Koch

Die Juden in Deutschland

von e. jüd. Deutschen [d.i. Friedrich Blach]

Ob die Volksschullehrer lesen dürfen? und wie sie lesen sollen?

von Georg Christoph Friedrich Gieseler

Die Juden in England vom achten Jahrhundert bis zur Gegenwart : ein kulturgeschichtl. Bild

von Karl Heinrich Schaible

Systematische Darstellung der in Betreff der Juden in Mähren und im k. k. Antheile Schlesiens erlassenen Gesetze und Verordnungen

von Hieronymus von Scari

Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus.

Her2 overexpression and amplification can be found in a significant subset of esophageal adenocarcinomas. The activity of Her2 has been shown to be modulated by molecular chaperones such as HSP90. We analyzed expression/amplification data for HSP90 and Her2 on 127 primary resected esophageal adenocarcinomas in order to evaluate a possible relationship between these two molecules. HSP90 expression determined by immunohistochemistry was observed in various levels. Thirty nine (39) tumors (30.7%) were classified as Her2-positive according to their immunoreactivity and amplification status. There was a significant correlation between HSP90 expression and Her2-status (p = 0.008). This could also be demonstrated by quantitative protein expression analysis with reverse phase protein arrays (r = 0.9; p < 0.001). Her2-status was associated withpT-category (p = 0.041), lymph node metastases (p = 0.049) and tumor differentiation (p = 0.036) with a higher percentage of cases with negative Her2 status in lower tumor stagesA negative Her2-status was also associated with better survival in univariate and multivariate analysis (p = 0.001 and p = 0.014). For HSP90, no associations between clinical and pathological parameters were found. The observed association between HSP90 expression and Her2 suggests a co-regulation of these molecules in at least a subset of esophageal adenocarcinomas. Anti-HSP90 drugs, which recently have been introduced in cancer treatment, may also be an option for these tumors by targeting HSP90 alone or in combination with Her2.

Der gewaltsame Kinderraub zu Bologna : zugl. e. Wort der Warnung an alle Concordatsfreunde

von Friedrich Albrecht

Der Geist der jüdischen Kultur und das Abendland

von Friedrich Muckle

Der Ritualmord vor den Gerichtshöfen der Wahrheit und Gerechtigkeit

von Fr. Frank