The VOP Voice, Septmeber 1, 2016, Vol. 9

Volunteer of Month - Shelley Turner, New Volunteers, Volunteer Anniversaries, Continuing Education, Residents Rights Mini-Seminars, In Memoriam of Roger Leff

The works of Alfred Lord Tennyson.

vol. II. Idylls of the king. To the queen.- vol. III. The princess. Maud. Enoch Arden. In memoriam.- vol. IV. Queen Mary. Harold. The lover's tale. Ballads and other poems. Sonnets. Translations, etc.- Vol. V. Tiresias and other poems. The promise of May. Demeter and other poems.- vol. VI. Becket. The cup. The falcon. The foresters. Balin and Balan. The death of Oenone, and other poems. Complete indexes.

La oración de san León papa: varia fortuna arqueológica de un librito-escapulario (con una nota tipobibliográfica sobre la imposición por medios pliegos)

Este trabajo analiza los avatares editoriales y el sistema de composición por medios pliegos de un librito-escapulario de principios el siglo XVI a través de las tres ediciones conocidas de La oración de San León papa. Es la versión previa, ilustrada con imágenes, del capítulo publicado en extracto en el Catálogo de la exposición "La fortuna de los libros" de la Biblioteca Lázaro Galdíano (2015), actualizada y dada a luz in memoriam de Víctor Infantes. Constituye la segunda entrega de la colección Papeles del divisorio, 2.

La igualdad de género : perspectivas del feminismo liberal y del feminismo de la diferencia a través de las novelas dimensión de la angustia y las andariegas

La presente disertación tiene como objetivo analizar la «igualdad de género» en el feminismo liberal y en el feminismo de la diferencia a través de las novelas literarias Dimensión de la angustia y Las andariegas. La influencia de algunas corrientes políticas puede permear ideológicamente herramientas como la literatura, que a su vez, puede cumplir una función de denuncia social basada en dicha influencia. Así, en Dimensión de la angustia se muestra cómo la igualdad de género es percibida como la consecución jurídica de una situación igualitaria, premisa básica del feminismo liberal; y, en Las andariegas se plasma la igualdad de género como la necesidad de crear una identidad propia de la mujer alejada de la creación social de «lo femenino», hipótesis que maneja el feminismo de la diferencia. En este sentido, para la realización del presente análisis se empleó el enfoque feminista, y se hizo uso de fuentes primarias como las obras Vindicación de los Derechos de la Mujer de Mary Wollstonecraft, y Espéculo de la otra mujer de Luce Irigaray, y como fuentes secundarias se usaron las novelas Dimensión de la Angustia y Las andariegas.

Breeding calabrian pepper lines (capsicum annuum L.) for Brazilian agriculture from sui generis introduction of germplasm.

This work aimed to report on the introduction of germplasm in a sui generis way and the initial results of Calabrian pepper breeding at Embrapa Vegetables.

Orbis terrae compendiosa descriptio : quam ex Magna Universali Gerardi Mercatoris domino Richardo Gartho, geographiae ac caeterarum bonarum artium amatori ac fautori summo, in veteris amicitiae ac familiaritatis memoriam

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Alexander episcopus seruus seruorum Dei, ad perpetuam Rei memoriam... in dicta Ecclesia Valentina omnino observentur... per Thomam vel Franciscum Riz. [Texto impreso]

Ejemplar incompleto, falto de p. 1 y 2

Christopheri Heinrici Loeberi historia ecclesiastica quae ephoriam Orlamundanam in Ducatu Altenburgensi describit, potentissimorum ac serenissimorum Saxoniae electorum ac Ducum studium propagandae veritatis divinae à temporibus reformationis refert, ipsam Reformationem per B. Lutherum factam, & quae tum temporis in his terris acta sunt, recenset, multa insuper notatu dignissima, de Carolstadio praesertim, & Flacio, qui Orlamundae docuerunt aliquando, aut innotuerunt, de libris symbolicis libro interim &c. annectit, memoriam tandem omnium ministrorum qui post pulsas papales tenebras in huius ephoriae ecclesiis verbum Dei docuerunt & adhuc docent, conservat; eorumpue nomina multis memorabilibus distinguit.

Title on two leaves.

Examen Canonis Levitici De Pvrificatione Pverperarvm ad ductum Levit. XII. Luc. II. ac lib. III. Decretal. tit. XLVII. : In perennem memoriam exoptatissimae dominicae Esto mihi CII II CCVII. Qua Serenissima ... Domina Wilhelmina Carolina ... Dn. Georgii Avgvsti, Dignitatum ac terrarum Electoralium Brunovico-Luneburgicarum Haeredis ... Conjux, Post felicissime superatum Primogeniti puerperium, laudum sacrificium Deo triuni offerebat ... /

Mode of access: Internet.

In Vivo Modulation of Mitochondrial Activity Determines HSC Engraftment and Post-Transplant Survival in Mice

Cellular metabolism is emerging as a potential fate determinant in cancer and stem cell biology, constituting a crucial regulator of the hematopoietic stem cell (HSC) pool [1-4]. The extremely low oxygen tension in the HSC microenvironment of the adult bone marrow forces HSCs into a low metabolic profile that is thought to enable their maintenance by protecting them from reactive oxygen species (ROS). Although HSC quiescence has for long been associated with low mitochondrial activity, as testified by the low rhodamine stain that marks primitive HSCs, we hypothesized that mitochondrial activation could be an HSC fate determinant in its own right. We thus set to investigate the implications of pharmacologically modulating mitochondrial activity during bone marrow transplantation, and have found that forcing mitochondrial activation in the post-transplant period dramatically increases survival. Specifically, we examined the mitochondrial content and activation profile of each murine hematopoietic stem and progenitor compartment. Long-term-HSCs (LT-HSC, Lin-cKit+Sca1+ (LKS) CD150+CD34-), short-term-HSCs (ST-HSC, LKS+150+34+), multipotent progenitors (MPPs, LKS+150-) and committed progenitors (PROG, Lin-cKit+Sca1-) display distinct mitochondrial profiles, with both mitochondrial content and activity increasing with differentiation. Indeed, we found that overall function of the hematopoietic progenitor and stem cell compartment can be resolved by mitochondrial activity alone, as illustrated by the fact that low mitochondrial activity LKS cells (TMRM low) can provide efficient long-term engraftment, while high mitochondrial activity LKS cells (TMRM high) cannot engraft in lethally irradiated mice. Moreover, low mitochondrial activity can equally predict efficiency of engraftment within the LT-HSC and ST-HSC compartments, opening the field to a novel method of discriminating a population of transitioning ST-HSCs that retain long-term engraftment capacity. Based on previous experience that a high-fat bone marrow microenvironment depletes short-term hematopoietic progenitors while conserving their long-term counterparts [5], we set to measure HSC mitochondrial activation in high-fat diet fed mice, known to decrease metabolic rate on a per cell basis through excess insulin/IGF-1 production. Congruently, we found lower mitochondrial activation as assessed by flow cytometry and RT-PCR analysis as well as a depletion of the short-term progenitor compartment in high fat versus control chow diet fed mice. We then tested the effects of a mitochondrial activator known to counteract the negative effects of high fat diet. We first analyzed the in vitro effect on HSC cell cycle kinetics, where no significant change in proliferation or division time was found. However, HSCs responded to the mitochondrial activator by increasing asynchrony, a behavior that is thought to directly correlate with asymmetric division [6]. As opposed to high-fat diet fed mice, mice fed with the mitochondrial activator showed an increase in ST-HSCs, while all the other hematopoietic compartments were comparable to mice fed on control diet. Given the dependency on short-term progenitors to rapidly reconstitute hematopoiesis following bone marrow transplantation, we tested the effect of pharmacological mitochondrial activation on the recovery of mice transplanted with a limiting HSC dose. Survival 3 weeks post-transplant was 80% in the treated group compared to 0% in the control group, as predicted by faster recovery of platelet and neutrophil counts. In conclusion, we have found that mitochondrial activation regulates the long-term to short-term HSC transition, unraveling mitochondrial modulation as a valuable drug target for post-transplant therapy. Identification of molecular pathways accountable for the metabolically mediated fate switch is currently ongoing.

Professori Kauko Pirisen julkaisutoiminta 1989-1995

Mikko Ketola & Hannu Mustakallio