Numerical study of circulation on the inner Amazon Shelf

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Systemic CA-MRSA infection following trauma during soccer match in inner Brazil: Clinical and molecular characterization

Even though community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) was described a decade ago, reports from Brazil are scarce and cases occurred in large urban centers. We report MRSA sepsis in a 16-year-old male from a small town and who had no history of exposure to healthcare or recent travel. After trauma during a soccer match, he presented swelling in the right thigh, which evolved in a month to cellulitis complicated by local abscess, orchitis and pneumonia. The patient presented severe sepsis, with fever and respiratory failure. Laboratory findings included blood leukocyte counts above 40,000/mm3 and thrombocytopenia. He was submitted to mechanical ventilation and therapy with vancomycin and imipenem. He had a slow but favorable response to therapy and was discharged after six weeks of hospitalization. MRSA grew from blood cultures and respiratory aspirates obtained before antimicrobial therapy. The isolate belonged to sequence type 5, spa type t311, harbored SCCmec type IV and genes for Panton-Valentine leukocidin and Enterotoxin A. The pulsed-field gel electrophoresis pattern was distinct from North American classic CA-MRSA clones. However, the sequence type and the spa type revealed that the clone belong to the same clonal complex isolated in Argentina. This is the first CA-MRSA infection reported in that region, with significant epidemiologic and clinical implications. © 2013 Elsevier Inc.

Resolución 6: Cotizaciones de emisiones de capital = Resolution 6: Quotations of capital issues = Résolution 6: Cotation des émissions de capital

El símbolo E/840/Rev.1 corresponde a la edición bilingüe inglés/francés publicada en 1953

On computational aspects of discrete Sobolev inner products on the unit circle

In this paper, we show how to compute in O(n2) steps the Fourier coefficients associated with the Gelfand-Levitan approach for discrete Sobolev orthogonal polynomials on the unit circle when the support of the discrete component involving derivatives is located outside the closed unit disk. As a consequence, we deduce the outer relative asymptotics of these polynomials in terms of those associated with the original orthogonality measure. Moreover, we show how to recover the discrete part of our Sobolev inner product. © 2013 Elsevier Inc. All rights reserved.

Shvo's catalyst in chemoenzymatic dynamic kinetic resolution of amines-inner or outer sphere mechanism?

Evidence is provided for the inner-sphere mechanism with actual metal coordination of the racemic amine in the crucial hydrogen transfer step promoted by Shvo's catalyst of the chemoenzymatic dynamic kinetic resolution (DKR) of amines. Key intermediates involved in this H-transfer step were intercepted and continuously monitored by electrospray ionization mass spectrometry (ESI-MS) and characterized by their dissociation chemistries via ESI-MS/MS. © 2013 The Royal Society of Chemistry.

Origin of the peculiar eccentricity distribution of the inner cold Kuiper belt

Dawson and Murray-Clay (Dawson and Murray-Clay [2012]. Astrophys. J., 750, 43) pointed out that the inner part of the cold population in the Kuiper belt (that with semi major axis a < 43.5 AU) has orbital eccentricities significantly smaller than the limit imposed by stability constraints. Here, we confirm their result by looking at the orbital distribution and stability properties in proper element space. We show that the observed distribution could have been produced by the slow sweeping of the 4/7 mean motion resonance with Neptune that accompanied the end of Neptune's migration process. The orbital distribution of the hot Kuiper belt is not significantly affected in this process, for the reasons discussed in the main text. Therefore, the peculiar eccentricity distribution of the inner cold population cannot be unequivocally interpreted as evidence that the cold population formed in situ and was only moderately excited in eccentricity; it can simply be the signature of Neptune's radial motion, starting from a moderately eccentric orbit. We discuss how this agrees with a scenario of giant planet evolution following a dynamical instability and, possibly, with the radial transport of the cold population. (C) 2014 Elsevier Inc. All rights reserved.

Bio-Optical Properties of the Inner Continental Shelf off Santos Estuarine System, Southeastern Brazil, and their Implications for Ocean Color Algorithm Performance

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Small hospitals matter: insights from the emergence and spread of vancomycin-resistant enterococci in 2 public hospitals in inner Brazil

Although vancomycin-resistant enterococci (VRE) are reported in Brazil since 1996, data on their impact over settings of different complexity are scarce. We performed a study aimed at identifying determinants ofVRE emergence and spread in a public hospital consortium (comprising 2 hospitals, with 318 and 57 beds) in inner Brazil. Molecular typing and case-control studies (addressing predictors of acquisition or clonality) were performed. Among 122 authocthonous isolates, 106 were Enterococcus faecium (22 clones), and 16, Enterococcus faecalis (5 clones). Incidence was greater in the small-sized hospital, and a previous admission to this hospital was associated with greater risk of VRE colonization or infection during admission to the larger one. Overall risk factors included comorbidities, procedures, and antimicrobials (piperacillin-tazobactam, cefepime, and imipenem). Risk factors varied among different hospitals, species, and clones. Our findings demonstrate that VRE can spread within low-complexity facilities and from these to larger hospitals. (C) 2015 Elsevier Inc. All rights reserved.

Evidence for dark matter in the inner Milky Way

The ubiquitous presence of dark matter in the Universe is today a central tenet in modern cosmology and astrophysics(1). Throughout the Universe, the evidence for dark matter is compelling in dwarfs, spiral galaxies, galaxy clusters as well as at cosmological scales. However, it has been historically difficult to pin down the dark matter contribution to the total mass density in the Milky Way, particularly in the innermost regions of the Galaxy and in the solar neighbourhood(2). Here we present an up-to-date compilation of Milky Way rotation curve measurements(3-13), and compare it with state-of-the-art baryonic mass distribution models(14-26). We show that current data strongly disfavour baryons as the sole contribution to the Galactic mass budget, even inside the solar circle. Our findings demonstrate the existence of dark matter in the inner Galaxy without making any assumptions about its distribution. We anticipate that this result will compel new model-independent constraints on the dark matter local density and profile, thus reducing uncertainties on direct and indirect dark matter searches, and will help reveal the structure and evolution of the Galaxy.

Neural differentiation from equine inner cell mass cells in vitro

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)