Les Annales coloniales : organe de la "France coloniale moderne" / directeur : Marcel Ruedel

1929/01/03 (A30,N1).

Les Annales coloniales : organe de la "France coloniale moderne" / directeur : Marcel Ruedel

1922/01/03 (A23,N1).

Les Annales coloniales : organe de la "France coloniale moderne" / directeur : Marcel Ruedel

1914/01/01 (A15,N1).

Les Annales coloniales : organe de la "France coloniale moderne" / directeur : Marcel Ruedel

1903/01/01 (A4,N1).

Les Annales coloniales : organe de la "France coloniale moderne" / directeur : Marcel Ruedel

1903/01/01 (A4,N1).

Beurling-Landau densities of weighted Fekete sets and correlation kernel estimates

Let $Q$ be a suitable real function on $C$. An $n$-Fekete set corresponding to $Q$ is a subset ${Z_{n1}},\dotsb, Z_{nn}}$ of $C$ which maximizes the expression $\Pi^n_i_{n1}+\dots+\delta_{znn})$ converges to the equilibrium measure $\Delta Q.1 _S$d$A$ as $n \rightarrow \infty$. In this note we prove that Fekete sets are, in a sense, maximally spread out with respect to the equilibrium measure. In general, our results apply only to a part of the Fekete set, which is at a certain distance away from the boundary of the droplet. However, for the potential $Q=|Z|^2$ we obtain results which hold globally, and we conjecture that such global results are true for a wide range of potentials.

Les Annales coloniales : organe de la "France coloniale moderne" / directeur : Marcel Ruedel

1926/01/04 (A27,N1).

Annales de finances publiques comparées

1936 (N1).

Annales de l'Institut national agronomique : administration, enseignement et recherche

1876 (A1,N1)-1877.

Annales de l'Institut national agronomique : administration, enseignement et recherche

1876 (A1,N1,DOUBLE)-1877.

Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.

Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 = 164, n3 = 178) and in two population-based samples (CoLaus, n4 = 5409; GIANT, n5 = 113809). In the discovery sample, TT carriers of rs7754794C>T had 1.08 kg/m2 (p = 0.04) lower BMI as compared to C-allele carriers. This observation was replicated in an independent psychiatric sample (-2.18 kg/m2; p = 0.009). The association of rs7754794C>T and BMI seemed stronger in subjects younger than 45 years (median of age). In the population-based sample, a moderate association was observed (-0.17 kg/m2; p = 0.02) among younger individuals (<45y). Interestingly, this association was totally driven by patients meeting lifetime criteria for atypical depression, i.e. major depressive episodes characterized by symptoms such as an increased appetite. Indeed, patients with atypical depression carrying rs7754794-TT had 1.17 kg/m2 (p = 0.04) lower BMI values as compared to C-allele carriers, the effect being stronger in younger individuals (-2.50 kg/m2; p = 0.03; interaction between rs7754794 and age: p-value = 0.08). This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.

Annales de la Confédération universelle des amis de la vérité : ... supplément à "la Bouche de fer"

1791 (N1)- (N2).

Annales de la jeunesse catholique : organe de l'Association catholique de la jeunesse française

1909/01/01 (A24,SER3,N1).

Annales de la jeunesse catholique : organe de l'Association catholique de la jeunesse française

1908/01/01 (A23,SER3,N1).

Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart.

AIMS: Notch1 signalling in the heart is mainly activated via expression of Jagged1 on the surface of cardiomyocytes. Notch controls cardiomyocyte proliferation and differentiation in the developing heart and regulates cardiac remodelling in the stressed adult heart. Besides canonical Notch receptor activation in signal-receiving cells, Notch ligands can also activate Notch receptor-independent responses in signal-sending cells via release of their intracellular domain. We evaluated therefore the importance of Jagged1 (J1) intracellular domain (ICD)-mediated pathways in the postnatal heart. METHODS AND RESULTS: In cardiomyocytes, Jagged1 releases J1ICD, which then translocates into the nucleus and down-regulates Notch transcriptional activity. To study the importance of J1ICD in cardiac homeostasis, we generated transgenic mice expressing a tamoxifen-inducible form of J1ICD, specifically in cardiomyocytes. Using this model, we demonstrate that J1ICD-mediated Notch inhibition diminishes proliferation in the neonatal cardiomyocyte population and promotes maturation. In the neonatal heart, a response via Wnt and Akt pathway activation is elicited as an attempt to compensate for the deficit in cardiomyocyte number resulting from J1ICD activation. In the stressed adult heart, J1ICD activation results in a dramatic reduction of the number of Notch signalling cardiomyocytes, blunts the hypertrophic response, and reduces the number of apoptotic cardiomyocytes. Consistently, this occurs concomitantly with a significant down-regulation of the phosphorylation of the Akt effectors ribosomal S6 protein (S6) and eukaryotic initiation factor 4E binding protein1 (4EBP1) controlling protein synthesis. CONCLUSIONS: Altogether, these data demonstrate the importance of J1ICD in the modulation of physiological and pathological hypertrophy, and reveal the existence of a novel pathway regulating cardiac homeostasis.