An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease

Although the presence of an olfactory impairment in Parkinson's disease (PD) has been recognized for 25 years, its cause remains unclear. Here we suggest a contributing factor to this impairment, namely, that PD impairs active sniffing of odorants. We tested 10 men and 10 women with clinically typical PD, and 20 age- and gender-matched healthy controls, in four olfactory tasks: (i) the University of Pennsylvania smell identification test; (ii and iii) detection threshold tests for the odorants vanillin and propionic acid; and (iv) a two-alternative forced-choice detection paradigm during which sniff parameters (airflow peak rate, mean rate, volume, and duration) were recorded with a pneomatotachograph-coupled spirometer. An additional experiment tested the effect of intentionally increasing sniff vigor on olfactory performance in 20 additional patients. PD patients were significantly impaired in olfactory identification (P < 0.0001) and detection (P < 0.007). As predicted, PD patients were also significantly impaired at sniffing, demonstrating significantly reduced sniff airflow rate (P < 0.01) and volume (P < 0.002). Furthermore, a patient's ability to sniff predicted his or her performance on olfactory tasks, i.e., the more poorly patients sniffed, the worse their performance on olfaction tests (P < 0.009). Finally, increasing sniff vigor improved olfactory performance in those patients whose baseline performance had been poorest (P < 0.05). These findings implicate a sniffing impairment as a component of the olfactory impairment in PD and further depict sniffing as an important component of human olfaction.

Minority Coaches in the NFL: An Examination of Hiring Patterns as a Basis for Recommendations for Improved Employment Practices

Hiring minority coaches is a serious concern in the National Football League (NFL). The NFL's hiring practices are inconsistent, specifically for minority candidates. The author investigates why NFL teams underutilize minority coaches with research from Central Florida University and the University of Pennsylvania. Research findings suggest that minority hires positively affect the NFL, yet the hiring process remains weak. Case study examples show the poor decision-making trends of NFL personnel, implying that although minority coaches' success is better than non-minorities, the negative perception of minorities, as aspiring head coaches and leaders, is a barrier. As a result, the NFL has a unique opportunity to improve its hiring process by aligning its approach to hiring within the guidelines of federal law.

Bandringa rayi: a new Ctenacanthoid shark from the Pennsylvania Essex fauna of Illinois / Rainer Zangerl --

v.12:no.10(1969)

The royal charter of King Charles the Second to William Penn, esquire, proprietor of the province of Pennsylvania, 1701

A copy of the charter giving William Penn land in the colonies. Also contains Penn's "Frame of the Government of Pennsylvania in America", the laws he established, and the charter of the city of Philadelphia.

An act for granting to His Majesty the sum of fifty-five thousand pounds, and for striking the same in bills of credit, in the manner herein after directed..., 1764

Contains an act for collection of taxes to pay the debt by establishing a set fee of fifteen shillings per head and household.

Commission of Noah Cooke, Jr., as chaplain in the Continental Army, signed by John Hancock, 1776 January 1

Commission of Noah Cooke, Jr., as chaplain in the Continental Army, signed by John Hancock, 1 January 1776.

Pittsburgh, Pennsylvania, 1900 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the cities of Pittsburgh, Allegheny and environs. It was published by R. L. Polk and Co. in 1900. Scale [ca. 1:11,800]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane NAD 1983 coordinate system (in Feet) (Fipszone 3702) coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, railroad stations, street railroads, drainage, selected public buildings, cemeteries, parks, city ward boundaries, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Philadelphia, Pennsylvania, 1797 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: This plan of the city of Philadelphia and it's environs (shewing the improved parts) is dedicated to the mayor, aldermen and citizens thereof, by their most obedient servant John Hills surveyor and draughtsman ; May 30th 1796 ; engraved by John Cooke of Hendon Middlesex near London. It was Published and Sold by John Hills Surveyor and Draughsman in 1797. Scale [1:7,200]. The image inside the map neatline is georeferenced to the surface of the earth and fit to Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas, selected public and private buildings, schools, churches, industry locations (e.g. mills, factories, mines, etc.), docks, fortification, ground cover, and more. Relief shown by hachures. Includes also references to points of interest. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.

Northeastern United States, 1799 : showing township grants and land purchases in New York (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the middle states of North America : shewing the position of the Geneseo country comprehending the counties of Ontario & Steuben as laid off in townships of six miles squar[e] each, Maverick, sculpt. It was printed by T. & J. Swords for Charles Williamson's Description of the settlement of the Genesee country, in the state of New-York, 1799. Scale [ca. 1:2,250,000]. Partial cadastral map showing large land purchases and township grants in New York State. Covers New York, Pennsylvania, Vermont, Massachusetts, Connecticut, New Jersey, Washington, D.C. and portions of Maryland, Delaware, and West Virginia. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, major cities and towns, land purchases, township grants, state boundaries, and more. Includes key to "principal villages in Ontario & Steuben counties." This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Philadelphia, Pennsylvania and vicinity, Landowners, 1681 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Fac-simile of a portion of Holme's map of the Province of Pennsylvania : with names of original purchasers from William Penn 1681. It was published by L. H. Everts & co. ca. 1884. Scale not given. Facsimile of a map published in 1681. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. Cadastral map showing townships, landowner names, property boundaries, drainage, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Philadelphia, Pennsylvania and Camden, New Jersey, 1886 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Plan of the city of Philadelphia and Camden, drawn and engraved by W.H. Gamble. It was published by Wm. M. Bradley & Bro. in 1886. Scale [ca.1:25,000]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings, city wards, parks, cemeteries, ferry routes, wharves, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Philadelphia, Pennsylvania and Camden, New Jersey, 1874 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Plan of the city of Philadelphia and Camden, drawn and engraved by W.H. Gamble. It was published by S. Augustus Mitchell Jr. in 1874. Scale [ca.1:25,000]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings, city wards, parks, cemeteries, wharves, ferry routes, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Philadelphia, Pennsylvania, 1882 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: New map of Philadelphia. It was published by Pickwick & Co., Booksellers in 1882. Scale not given. Covers also a portion of Camden, New Jersey. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings, city wards, parks, cemeteries, wharves, ferry routes, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Philadelphia, Pennsylvania, 1893 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: New map of the city of Philadelphia :from the latest city surveys : prepared for Gopsill's directories 1893. It was published by J.L. Smith in 1893. Scale [ca.1:21,500]. Covers Philadelphia and a portion of surrounding cities. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings, cemeteries, parks, city wards, and more. Includes three indices: Street directory -- Statistical notes -- Elevation of the highest recorded points above high tides in the Delaware River. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Philadelphia, Pennsylvania, 1794 (Raster Image) (Image 1 of 2)

This layer is a georeferenced raster image of the historic paper map entitled: To Thomas Mifflin, governor and commander in chief of the state of Pennsylvania, this plan of the city and suburbs of Philadelphia is respectfully inscribed by the editor, 1794, A.P. Folie del. ; R. Scot & S. Allardice sculpsit. It was published in 1794. Scale [ca. 1:6,800]. This layer is image 1 of 2 total images of the two sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, selected public and private buildings, and more. Relief is shown by hachures. Includes index to points of interest, ill., and coat of arms held by two female figures. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.