Individual assets, market structure and the drivers of return

Much UK research and market practice on portfolio strategy and performance benchmarking relies on a sector‐geography subdivision of properties. Prior tests of the appropriateness of such divisions have generally relied on aggregated or hypothetical return data. However, the results found in aggregate may not hold when individual buildings are considered. This paper makes use of a dataset of individual UK property returns. A series of multivariate exploratory statistical techniques are utilised to test whether the return behaviour of individual properties conforms to their a priori grouping. The results suggest strongly that neither standard sector nor regional classifications provide a clear demarcation of individual building performance. This has important implications for both portfolio strategy and performance measurement and benchmarking. However, there do appear to be size and yield effects that help explain return behaviour at the property level.

Identification of potential drug targets in Salmonella Typhimurium using metabolic modelling and experimental validation

almonella enterica serovar Typhimurium is an established model organism for Gram-negative, intracellular pathogens. Owing to the rapid spread of resistance to antibiotics among this group of pathogens, new approaches to identify suitable target proteins are required. Based on the genome sequence of Salmonella Typhimurium and associated databases, a genome-scale metabolic model was constructed. Output was based on an experimental determination of the biomass of Salmonella when growing in glucose minimal medium. Linear programming was used to simulate variations in energy demand, while growing in glucose minimal medium. By grouping reactions with similar flux responses, a sub-network of 34 reactions responding to this variation was identified (the catabolic core). This network was used to identify sets of one and two reactions, that when removed from the genome-scale model interfered with energy and biomass generation. 11 such sets were found to be essential for the production of biomass precursors. Experimental investigation of 7 of these showed that knock-outs of the associated genes resulted in attenuated growth for 4 pairs of reactions, while 3 single reactions were shown to be essential for growth.

Physical analyses of compost from composting plants in Brazil

Nowadays the composting process has shown itself to be an alternative in the treatment of municipal solid wastes by composting plants. However, although more than 50% of the waste generated by the Brazilian population is composed of matter susceptible to organic composting, this process is, still today, insufficiently developed in Brazil, due to low compost quality and lack of investments in the sector. The objective of this work was to use physical analyses to evaluate the quality of the compost produced at 14 operative composting plants in the Sao Paulo State in Brazil. For this purpose, size distribution and total inert content tests were done. The results were analyzed by grouping the plants according to their productive processes: plants with a rotating drum, plants with shredders or mills, and plants without treatment after the sorting conveyor belt. Compost quality was analyzed considering the limits imposed by the Brazilian Legislation and the European standards for inert contents. The size distribution tests showed the influence of the machinery after the sorting conveyer on the granule sizes as well as the inert content, which contributes to the presence of materials that reduce the quality of the final product. (C) 2007 Elsevier Ltd. All rights reserved.

HiPP: A Novel Hierarchical Point Placement Strategy and its Application to the Exploration of Document Collections

Point placement strategies aim at mapping data points represented in higher dimensions to bi-dimensional spaces and are frequently used to visualize relationships amongst data instances. They have been valuable tools for analysis and exploration of data sets of various kinds. Many conventional techniques, however, do not behave well when the number of dimensions is high, such as in the case of documents collections. Later approaches handle that shortcoming, but may cause too much clutter to allow flexible exploration to take place. In this work we present a novel hierarchical point placement technique that is capable of dealing with these problems. While good grouping and separation of data with high similarity is maintained without increasing computation cost, its hierarchical structure lends itself both to exploration in various levels of detail and to handling data in subsets, improving analysis capability and also allowing manipulation of larger data sets.

Study of environmental burden of lead in children using teeth as bioindicator

The south region of Sao Paulo city hosts the Guarapiranga dam, responsible for water supply to 25% of the city population. Their surroundings have been subject to intense and irregular occupation by people from very low socioeconomics classes. Measurements undertaken on sediment and particulate materials in the dam revealed concentrations of lead. copper, zinc and cadmium above internationally accepted limits. Epidemiological and toxicological studies undertaken by the World Health Organization in individuals exhibiting lead concentrations in blood, near or below the maximum recommended (10 mu g dl(-1)), surprisingly revealed that toxic effects are more intense in individuals belonging to low socioeconomics classes. Motivated by these facts, we aimed at the investigation of chronic incorporation of lead. as well as the use of our BIOKINETICS code, which is based on an accepted ICRP biokinetics model for lead, in order to extrapolate the results from teeth to other organs. The focus of our data taking was children from poor families, living in a small, restrict and allegedly contaminated area in Sao Paulo city. Thus, a total of 74 human teeth were collected. The average concentration of lead in teeth of children 5 to 10 years old was determined by means of a high-resolution inductively coupled plasma mass spectrometer (ICP-MS). For standardization of the measurements, an animal bone certified material (H-Animal Bone), from the International Atomic Energy Agency, was analyzed. The amount of lead in children living in the surroundings of the dam, was approximately 40% higher than those from the control region, and the average lead concentration was equal to 1.3 mu g g(-1) approximately. Grouping the results in terms of gender, tooth type and condition, it was concluded that a carious molar of boys is a much more efficient contamination pathway for lead, resulting in concentrations 70% higher than in the control region. We also inferred the average concentrations of lead in other organs of these children, by making use of our BIOKINETIC code. (C) 2008 Elsevier Ltd. All rights reserved.

The Aedes aegypti larval transcriptome: a comparative perspective with emphasis on trypsins and the domain structure of peritrophins

The genome sequence of Aedes aegypti was recently reported. A significant amount of Expressed Sequence Tags (ESTs) were sequenced to aid in the gene prediction process. In the present work we describe an integrated analysis of the genomic and EST data, focusing on genes with preferential expression in larvae (LG), adults (AG) and in both stages (SG). A total of 913 genes (5.4% of the transcript complement) are LG, including ion transporters and cuticle proteins that are important for ion homeostasis and defense. From a starting set of 245 genes encoding the trypsin domain, we identified 66 putative LG, AG, and SG trypsins by manual curation. Phylogenetic analyses showed that AG trypsins are divergent from their larval counterparts (LG), grouping with blood-induced trypsins from Anopheles gambiae and Simulium vittatum. These results support the hypothesis that blood-feeding arose only once, in the ancestral Culicomorpha. Peritrophins are proteins that interlock chitin fibrils to form the peritrophic membrane (PM) that compartmentalizes the food in the midgut. These proteins are recognized by having chitin-binding domains with 6 conserved Cys and may also present mucin-like domains (regions expected to be highly O-glycosylated). PM may be formed by a ring of cells (type 2, seen in Ae. aegypti larvae and Drosophila melanogaster) or by most midgut cells (type 1, found in Ae. aegypti adult and Tribolium castaneum). LG and D. melanogaster peritrophins have more complex domain structures than AG and T. castaneum peritrophins. Furthermore, mucin-like domains of peritrophins from T. castaneum (feeding on rough food) are lengthier than those of adult Ae. aegypti (blood-feeding). This suggests, for the first time, that type 1 and type 2 PM may have variable molecular architectures determined by different peritrophins and/or ancillary proteins, which may be partly modulated by diet.

A quantum chemical study on a set of non-imidazole H(3) antihistamine molecules

Molecular orbital calculations were carried out on a set of 28 non-imidazole H(3) antihistamine compounds using the Hartree-Fock method in order to investigate the possible relationships between electronic structural properties and binding affinity for H3 receptors (pK(i)). It was observed that the frontier effective-for-reaction molecular orbital (FERMO) energies were better correlated with pK(i) values than highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy values. Exploratory data analysis through hierarchical cluster (HCA) and principal component analysis (PCA) showed a separation of the compounds in two sets, one grouping the molecules with high pK(i) values, the other gathering low pK(i) value compounds. This separation was obtained with the use of the following descriptors: FERMO energies (epsilon(FERMO)), charges derived from the electrostatic potential on the nitrogen atom (N(1)), electronic density indexes for FERMO on the N(1) atom (Sigma((FERMO))c(i)(2)). and electrophilicity (omega`). These electronic descriptors were used to construct a quantitative structure-activity relationship (QSAR) model through the partial least-squares (PLS) method with three principal components. This model generated Q(2) = 0.88 and R(2) = 0.927 values obtained from a training set and external validation of 23 and 5 molecules, respectively. After the analysis of the PLS regression equation and the values for the selected electronic descriptors, it is suggested that high values of FERMO energies and of Sigma((FERMO))c(i)(2), together with low values of electrophilicity and pronounced negative charges on N(1) appear as desirable properties for the conception of new molecules which might have high binding affinity. 2010 Elsevier Inc. All rights reserved.

Electrical Evaluation of a Low Concentrating PVT Collector Based on Performance Ratio

Photovoltaic Thermal/Hybrid collectors are an emerging technology that combines PV and solar thermal collectors by producing heat and electricity simultaneously. In this paper, the electrical performance evaluation of a low concentrating PVT collector was done through two testing parts: power comparison and performance ratio testing. For the performance ratio testing, it is required to identify and measure the factors affecting the performance ratio on a low concentrating PVT collector. Factors such as PV cell configuration, collector acceptance angle, flow rate, tracking the sun, temperature dependence and diffuse to irradiance ratio. Solarus low concentrating PVT collector V12 was tested at Dalarna University in Sweden using the electrical equipment at the solar laboratory. The PV testing has showed differences between the two receivers. Back2 was producing 1.8 energy output more than Back1 throughout the day. Front1 and Front2 were almost the same output performance. Performance tests showed that the cell configuration for Receiver2 with cells grouping (6- 32-32-6) has proved to have a better performance ratio when to it comes to minimizing the shading effect leading to more output power throughout the day because of lowering the mismatch losses. Different factors were measured and presented in this thesis in chapter 5. With the current design, it has been obtained a peak power at STC of 107W per receiver. The solar cells have an electrical efficiency of approximately 19% while the maximum measured electrical efficiency for the collector was approximately 18 % per active cell area, in addition to a temperature coefficient of -0.53%/ ˚C. Finally a recommendation was done to help Solarus AB to know how much the electrical performance is affected during variable ambient condition and be able to use the results for analyzing and introducing new modification if needed.

Hushållsavfall i Borlänge kommun : analyser av material en och flerfamiljshus

In Borlänge, source separation has been the basis for management of household waste for over five years. This report reviews today?s system and gives a model for further follow-up through waste grouping. In the basic system waste is separated into three fractions: biodegradable, waste to energy and waste to landfill. All waste is packed in plastic bags, put in separate containers for each fraction, and collected from the property. Separate analyses were made of waste from single family houses and apartment buildings. The amount of waste per household and week, number of non-sorted bags, purity, recovery rate and density of each fraction was calculated. The amount of packaging collected together with the household waste is given. Material collected under the Swedish law of Producers? Responsibility is not covered in this report.

Recording and Using Provenance in a Protein Compressibility Experiment

Very large scale computations are now becoming routinely used as a methodology to undertake scientific research. In this context, `provenance systems' are regarded as the equivalent of the scientist's logbook for in silico experimentation: provenance captures the documentation of the process that led to some result. Using a protein compressibility analysis application, we derive a set of generic use cases for a provenance system. In order to support these, we address the following fundamental questions: what is provenance? how to record it? what is the performance impact for grid execution? what is the performance of reasoning? In doing so, we define a technologyindependent notion of provenance that captures interactions between components, internal component information and grouping of interactions, so as to allow us to analyse and reason about the execution of scientific processes. In order to support persistent provenance in heterogeneous applications, we introduce a separate provenance store, in which provenance documentation can be stored, archived and queried independently of the technology used to run the application. Through a series of practical tests, we evaluate the performance impact of such a provenance system. In summary, we demonstrate that provenance recording overhead of our prototype system remains under 10% of execution time, and we show that the recorded information successfully supports our use cases in a performant manner.

Reasoning about Requirements Evolution Using Clustered Belief Revision

During the development of system requirements, software system specifications are often inconsistent. Inconsistencies may arise for different reasons, for example, when multiple conflicting viewpoints are embodied in the specification, or when the specification itself is at a transient stage of evolution. These inconsistencies cannot always be resolved immediately. As a result, we argue that a formal framework for the analysis of evolving specifications should be able to tolerate inconsistency by allowing reasoning in the presence of inconsistency without trivialisation, and circumvent inconsistency by enabling impact analyses of potential changes to be carried out. This paper shows how clustered belief revision can help in this process. Clustered belief revision allows for the grouping of requirements with similar functionality into clusters and the assignment of priorities between them. By analysing the result of a cluster, an engineer can either choose to rectify problems in the specification or to postpone the changes until more information becomes available.

Perfil da indústria de alimentos no Brasil: 1990-1995

A pesquisa sobre o perfil da indústria de alimentos no período de 1990-95 observou uma superior participação do grupo de produtos de maior valor agregado, com destaque para os laticínios, assim como um aumento do consumo de alimentos em geral propiciado pelo aumento da renda real dos trabalhadores após o Plano Real. Constataram-se, também, ajustes aos novos padrões de competitividade devido à abertura de mercado, com conseqüências na diminuição das margens líquidas e do número de emprego.

From XML to relational view updates: applying old solutions to solve a new problem

XML has become an important medium for data exchange, and is frequently used as an interface to - i.e. a view of - a relational database. Although lots of work have been done on querying relational databases through XML views, the problem of updating relational databases through XML views has not received much attention. In this work, we give the rst steps towards solving this problem. Using query trees to capture the notions of selection, projection, nesting, grouping, and heterogeneous sets found throughout most XML query languages, we show how XML views expressed using query trees can be mapped to a set of corresponding relational views. Thus, we transform the problem of updating relational databases through XML views into a classical problem of updating relational databases through relational views. We then show how updates on the XML view are mapped to updates on the corresponding relational views. Existing work on updating relational views can then be leveraged to determine whether or not the relational views are updatable with respect to the relational updates, and if so, to translate the updates to the underlying relational database. Since query trees are a formal characterization of view de nition queries, they are not well suited for end-users. We then investigate how a subset of XQuery can be used as a top level language, and show how query trees can be used as an intermediate representation of view de nitions expressed in this subset.

Influência da composição do grupo (turma escolar), entre crianças da primeira serie do 1. grau, sobre a estrutura sócio-afetiva

Neste estudo discutem-se as influências da forma de composição do grupo (turma escolar), entre crianças da primeira série do 1º Grau, em função da maturidade necessária à aprendizagem da leitura e da escrita, relativamente à estrutura e mudança da estrutura sócio-afetiva. O problema teve origem no questionamento em torno do valor da prática e suas possíveis influências sobre o desenvolvimento social da criança que, por volta dos sete anos de idade - coincidindo com a entrada para a escola - é mais fortemente incrementado. O suporte teórico do estudo é dado pela Teoria de Campo de Kurt Lewin. O percentual de indicações positivas (PIP) , o percentual de indicações negativas (PIN) , o destaque da posição sociométrica (D), a qualidade do destaque (Qd) , e a mudança das posições sociométricas dos indivíduos nos grupos (MPS) , - constituiram-se em indicadores da variável composição do grupo. Do estudo realizado conclui-se que as formas homogênea e heterogênea de composição do grupo influenciaram de maneira não significativamente diferente em relação à estrutura e a mudança da estrutura sócio-afetiva do grupo, sendo, portanto, injustificada a prática da homogeneização das classes escolares em relação a estes aspectos.

Missão organizacional, uma questão de discurso?: por uma análise crítica

A partir do entendimento de que as grandes corporações são poderosos agentes políticos, econômicos e sociais e que suas missões organizacionais sintetizam a sua razão de ser e existir, o estudo tem como objetivo desvelar o conteúdo político e ideológico subjacente ao discurso empresarial das missões das maiores empresas do Brasil. Assim, foram analisadas as missões divulgadas nas homepages institucionais e/ ou de relações com investidores das 64 empresas que compõem a carteira teórica do Ibovespa, principal indicador do desempenho médio das cotações do mercado de ações brasileiro. Os dados foram analisados à luz das tendências de apropriação do simbolismo pela cultura organizacional, da Análise Crítica do Discurso (ACD), instrumento teórico transdisciplinar que busca compreender a relação entre linguagem, poder, ideologia e sociedade e da perspectiva foucaultiana de discurso, entendendo-o como um espaço de luta pela estabilização dos sentidos, que se pretendem hegemônicos. Os dados foram tratados de forma quantitativa, em busca das palavras de uso mais frequente e, consequentemente de maior relevância, e qualitativa, agrupando-as em categorias lexicais em função de seu significado e de seu papel na declaração de missão organizacional. Os resultados revelam a estrutura subjacente do discurso das missões, permitindo a identificação de perfis específicos de empresas segundo suas características discursivas. Além disso, o trabalho discute como o discurso empresarial se apropria da dimensão simbólica com o propósito de controlar e manipular os trabalhadores, legitimar a atuação das empresas perante a sociedade e naturalizar os preceitos da ideologia neoliberal, apresentando o sistema capitalista atual como a única, melhor e inexorável forma de organização e de produção societária.