Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients - A position paper endorsed by ESMINT and ESNR : Part II: methodology of future trials

Based on current data and experience, the joint working group of the European Society of Minimally Invasive Neurological Therapy (ESMINT) and the European Society of Neuroradiology (ESNR) make suggestions on trial design and conduct aimed to investigate therapeutic effects of mechanical thrombectomy (MT). We anticipate that this roadmap will facilitate the setting up and conduct of successful trials in close collaboration with our neighbouring disciplines.

Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients: a position paper endorsed by ESMINT and ESNR : Part I: Current situation and major research questions

A new era of stroke treatment may have begun with mechanical thrombectomy (MT) by fully deployed closed-cell self-expanding stents (stent-triever). Multiple case series and the first randomised controlled trials (RCTs) have now been published. More studies are under way involving large numbers of patients, which in turn has resulted in less strict "pragmatic" study protocols. Problems with current trials include a lack of standardisation in the conduct of the recanalisation procedure, the definition of primary endpoints such as the grade of arterial recanalisation and tissue reperfusion, and the post-surgical care provided. In Part 1 of this two part series, we outline the current situation and the major research questions.

Detrital Zircon Evidence for Mixing of Mazatzal Province Age Detritus With Yavapai Age (ca. 1700-1740 Ma) and Older Detritus in the ca. 1650 Ma Mazatzal Province of Central New Mexico, USA

Preliminary detrital zircon age distributions from Mazatzal crustal province quartzite and schist exposed in the Manzano Mountains and Pedernal Hills of central New Mexico are consistent with a mixture of detritus from Mazatzal age (ca. 1650 Ma), Yavapai age (ca. 1720 Ma.), and older sources. A quartzite sample from the Blue Springs Formation in the Manzano Mountains yielding 67 concordant grain analyses shows two dominant age peaks of 1737 Ma and 1791 Ma with a minimum peak age of 1652 Ma. Quartzite and micaceous quartzite samples from near Pedernal Peak give unimodal peak ages of ca. 1695 Ma and 1738 Ma with minimum detrital zircon ages of ca. 1625 Ma and 1680 Ma, respectively. A schist sample from the southern exposures of the Pedernal Hills area gives a unimodal peak age of 1680 Ma with a minimum age of ca. 1635 Ma. Minor amounts of older detritus (>1800 Ma) possibly reflect Trans-Hudson, Wyoming, Mojave Province, and older Archean sources and aid in locating potential source terrains for these detrital zircon. The Blue Springs Formation metarhyolite from near the top of the Proterozoic section in the Manzano Mountains yields 71 concordant grains that show a preliminary U-Pb zircon crystallization age of 1621 ¿ 5 Ma, which provides a minimum age constraint for deposition in the Manzano Mountains. Normalized probability plots from this study are similar to previously reported age distributions in the Burro and San Andres Mountains in southern New Mexico and suggest that Yavapai Province age detritus was deposited and intermingled with Mazatzal Province age detritus across much of the Mazatzal crustal province in New Mexico. This data shows that the tectonic evolution of southwestern Laurentia is associated with multiple orogenic events. Regional metamorphism and deformation in the area must postdate the Mazatzal Orogeny and ca. 1610 Ma ¿ 1620 Ma rhyolite crystallization and is attributed to the Mesoproterozoic ca. 1400 ¿ 1480 Ma Picuris Orogeny.

Sulle tracce del primo Neoclassicismo. Il viaggio del principe ereditario Friedrich Christian di Sassonia in Italia (1738-1740)

Vom 13. Mai 1738 bis zum 7. September 1740 befindet sich der sächsische Kurprinz Friedrich Christian (1722-1764) auf seiner Italienreise. Sein eigenhändig geschriebenes Reisejournal, sowie die Berichte seines Tutors geben einen tiefen Einblick über das aktuelle Kunstgeschehen in Rom. Friedrich Christian wird durch die Fürsorge der Kardinäle Alessandro und Annibale Albani mit der intellektuellen Elite und mit den namhaftesten in Rom wirkenden Künstlern sowie mit der Kunst Raphaels und der bolognesisch-römischen Barock-Klassizisten bekannt beziehungsweise vertraut gemacht. In der römischen Akademie der Arkadier und in der Académie de France kommt er mit dem Ideal der Simplizität und der 'Nachahmung' der Antike in Berührung. Auf seinem Rückweg von Rom nach Venedig ist hierfür der Aufenthalt bei Scipione Maffei in Verona bezeichnend. In Venedig schließlich kann im besonderen Friedrich Christians Kenntnis von der Inventarisation des dortigen 'Statuario Pubblico', der ehemaligen Antikensammlung in der Antisala der Bibliothek von San Marco verzeichnet werden. Friedrich Christian kehrte mit diesen neuen Eindrücken nach Dresden zurück, wo Anton Raphael Mengs seine Karriere als Künstler begann und ein paar Jahre später sich Johann Joachim Winckelmann aufhielt. Unter der Obhut des Kardinals Alessandro Albani sollten Mengs und Winckelmann dann in Rom die malerische und theoretische Grundlage für den Klassizismus schaffen.

Elegie als Frau Francisca, Freyinn von Arnstein, geb. Itzig, am 8. Juny 1818 uns entrissen wurde

(Verf.[[Elektronische Ressource]] : Riedinger)

Festschrift zum hundertjährigen Bestehen des Israelitischen Tempels in Hamburg 1818 - 1918

hrsg. von D. Leimdörfer