Trabajo interdisciplinario de historia e informática en América Latina.

Las nuevas tecnologías, específicamente, los equipos digitales han hecho mucho más atractivos para los estudiantes el aprendizaje que las tradicionales y antiguas clases. Este trabajo se centra en la informática como herramienta para el aprendizaje. A comienzos del siglo XXI la sociedad, sin necesidad de leer, puede recibir mensajes mediante la imagen y la palabra y, por consiguiente, se masifica. El ordenador es una herramienta muy importante que tiene el docente a su alcance para mejorar el manejo de la información y el rendimiento escolar de sus alumnos. Para lograr esto es necesario trabajar de forma interdisciplinaria y, unir los distintos conocimientos para que el alumno pueda visualizar el conjunto de la realidad que lo circunda. Se presentan los modelos basados en la experiencia didáctica y se muestran las posibilidades interdisciplinarias, una práctica general que puede ser utilizada en varios ambientes escolares y en prácticamente todas las asignaturas, completada con la utilización de la informática. Finalmente, se examinan casos específicos de escuelas brasileñas.

Diseño y desarrollo de unidades didácticas en la escuela primaria.

Este libro examina el papel del trabajo con unidades didácticas globalizadas, en los términos del debate actual sobre el currículum de la educación primaria, refiriéndose, sobre todo, al equilibrio, continuidad, progresión y diferenciación. Presenta estudios de casos en los que el alumnado y el profesorado actúan en colaboración a la hora de elegir, desarrollar y supervisar cada tópico; de este modo, se amplían las oportunidades para la obtención de destrezas y actitudes adicionales, y los alumnos-as aprenden a evaluar su propio aprendizaje. Además, el libro ofrece: ejemplos prácticos del trabajo por tópicos con niños-as de todas las edades comprendidas en la enseñanza primaria; formas de analizar el trabajo por tópicos con el fin de establecer una coherencia entre las metas educativas y la práctica; un apéndice con ejemplos para plantear objetivos, realizar planificaciones de las lecciones, analizar y supervisar el tópico y el progreso del aprendizaje individual.

Teaching humanities in primary schools.

Esta guía ayuda a los profesores en período de formación inicial a superar el Qualified Teacher Status (QTS), aunque también es de utilidad para la etapa de infantil y para la estrategia nacional de primaria para la alfabetización y las matemáticas. Asimismo, desarrolla un enfoque integrador e intercurricular del aprendizaje y de la enseñanza de las materias centrales de las humanidades: geografía, historia y religión.

The science teacher's activity-a-day: over 180 reproducible pages of kick, fun projects that illustrate basic concepts.

Recurso para enseñar ciencias a los estudiantes de secundaria. Cada una de las ciento ochenta actividades tiene una duración de cinco minutos y están pensadas para captar la atención del alumno. Comienza con una breve explicación del concepto sobre el que se va a centrar e incluye una lista de materiales, el procedimiento a seguir, las preguntas de seguimiento, y las ampliaciones. Dividido en tres unidades: Ciencias Físicas, Ciencias de la Vida, y Ciencias de la Tierra y del Universo, las actividades son especialmente estimulantes para alumnos kinestésicos, ya que la mayoría de estos alumnos aprenden mejor al estar físicamente en contacto con la experiencia de aprendizaje. Todas deben estar supervisadas por un adulto y los estudiantes seguir las reglas de seguridad de de las clases de ciencias.

Helping immigrants identify as 'university-bound students' : unexpected difficulties in teaching the hidden curriculum. 'Ayudar a los inmigrantes a identificarse como 'estudiantes con destino a la universidad' : dificultades inesperadas en la enseñanza del currículo oculto'.

Monográfico con el título: 'Identidad y educación'. Resumen basado en el de la publicación

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

We elucidate the detailed effects of gut microbial depletion on the bile acid sub-metabolome of multiple body compartments (liver, kidney, heart, and blood plasma) in rats. We use a targeted ultraperformance liquid chromatography with time of flight mass-spectrometry assay to characterize the differential primary and secondary bile acid profiles in each tissue and show a major increase in the proportion of taurine-conjugated bile acids in germ-free (GF) and antibiotic (streptomycin/penicillin)-treated rats.Although conjugated bile acids dominate the hepatic profile (97.0 ± 1.5%) of conventional animals, unconjugated bile acids comprise the largest proportion of the total measured bile acid profile in kidney (60.0±10.4%) andheart (53.0 ± 18.5%) tissues. In contrast, in the GF animal, taurine-conjugated bile acids (especially taurocholic acid and tauro-β-muricholic acid) dominated the bile acid profiles (liver: 96.0 ± 14.5%; kidney: 96 ± 1%; heart: 93 ± 1%; plasma: 93.0 ± 2.3%), with unconjugated and glycine-conjugated species representing a small proportion of the profile. Higher free taurine levels were found in GF livers compared with the conventional liver (5.1-fold; P < 0.001). Bile acid diversity was also lower in GF and antibiotic-treated tissues compared with conventional animals. Because bile acids perform important signaling functions, it is clear that these chemical communication networks are strongly influencedbymicrobial activitiesormodulation, as evidenced by farnesoid X receptor-regulated pathway transcripts. The presence of specific microbial bile acid co-metabolite patterns in peripheral tissues (including heart and kidney) implies a broader signaling role for these compounds and emphasizes the extent of symbiotic microbial influences in mammalian homeostasis.

Gut microbiota modulate the metabolism of brown adipose tissue in mice

A two by two experimental study has been designed to determine the effect of gut microbiota on energy metabolism in mouse models. The metabolic phenotype of germ-free (GF, n = 20) and conventional (n = 20) mice was characterized using a NMR spectroscopy-based metabolic profiling approach, with a focus on sexual dimorphism (20 males, 20 females) and energy metabolism in urine, plasma, liver, and brown adipose tissue (BAT). Physiological data of age-matched GF and conventional mice showed that male animals had a higher weight than females in both groups. In addition, conventional males had a significantly higher total body fat content (TBFC) compared to conventional females, whereas this sexual dimorphism disappeared in GF animals (i.e., male GF mice had a TBFC similar to those of conventional and GF females). Profiling of BAT hydrophilic extracts revealed that sexual dimorphism in normal mice was absent in GF animals, which also displayed lower BAT lactate levels and higher levels of (D)-3-hydroxybutyrate in liver, plasma, and BAT, together with lower circulating levels of VLDL. These data indicate that the gut microbiota modulate the lipid metabolism in BAT, as the absence of gut microbiota stimulated both hepatic and BAT lipolysis while inhibiting lipogenesis. We also demonstrated that (1)H NMR metabolic profiles of BAT were excellent predictors of BW and TBFC, indicating the potential of BAT to fight against obesity.

A metabolic system-wide characterisation of the pig: a model for human physiology

The pig is a single-stomached omnivorous mammal and is an important model of human disease and nutrition. As such, it is necessary to establish a metabolic framework from which pathology-based variation can be compared. Here, a combination of one and two-dimensional (1)H and (13)C nuclear magnetic resonance spectroscopy (NMR) and high-resolution magic angle spinning (HR-MAS) NMR was used to provide a systems overview of porcine metabolism via characterisation of the urine, serum, liver and kidney metabolomes. The metabolites observed in each of these biological compartments were found to be qualitatively comparable to the metabolic signature of the same biological matrices in humans and rodents. The data were modelled using a combination of principal components analysis and Venn diagram mapping. Urine represented the most metabolically distinct biological compartment studied, with a relatively greater number of NMR detectable metabolites present, many of which are implicated in gut-microbial co-metabolic processes. The major inter-species differences observed were in the phase II conjugation of extra-genomic metabolites; the pig was observed to conjugate p-cresol, a gut microbial metabolite of tyrosine, with glucuronide rather than sulfate as seen in man. These observations are important to note when considering the translatability of experimental data derived from porcine models.

Colonization-induced host-gut microbial metabolic interaction

The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems. We have probed the systemic metabolic adaptation to gut colonization for 20 days following exposure of axenic mice (n = 35) to a typical environmental microbial background using high-resolution (1)H nuclear magnetic resonance (NMR) spectroscopy to analyze urine, plasma, liver, kidney, and colon (5 time points) metabolic profiles. Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization with parallel changes in multiple pathways in all compartments analyzed. The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis. These changes were associated with modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites, including taurocholate and tauromuricholate, which are essential regulators of lipid absorption. Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated. Remarkably, statistical modeling of the interactions between hepatic metabolic profiles and microbial composition analyzed by 16S rRNA gene pyrosequencing revealed strong associations of the Coriobacteriaceae family with both the hepatic triglyceride, glucose, and glycogen levels and the metabolism of xenobiotics. These data demonstrate the importance of microbial activity in metabolic phenotype development, indicating that microbiota manipulation is a useful tool for beneficially modulating xenobiotic metabolism and pharmacokinetics in personalized health care. IMPORTANCE: Gut bacteria have been associated with various essential biological functions in humans such as energy harvest and regulation of blood pressure. Furthermore, gut microbial colonization occurs after birth in parallel with other critical processes such as immune and cognitive development. Thus, it is essential to understand the bidirectional interaction between the host metabolism and its symbionts. Here, we describe the first evidence of an in vivo association between a family of bacteria and hepatic lipid metabolism. These results provide new insights into the fundamental mechanisms that regulate host-gut microbiota interactions and are thus of wide interest to microbiological, nutrition, metabolic, systems biology, and pharmaceutical research communities. This work will also contribute to developing novel strategies in the alteration of host-gut microbiota relationships which can in turn beneficially modulate the host metabolism.