Vota decisiva a Francisco Maria Constantino nobili Asculano, celebratissimo juris utriusque consulto, ac Romanae Curiae advocato elucubrata in causis, in quibus ... vel definitivè pronunciavit, aùt in sensu veritatis respondit, nunc vero primum a J.U.D. Cosmo Mathia Constantino authoris pridem defuncti pronepote in lucem edita ... tomus II.

Mode of access: Internet.

Magnum Bullarium romanum a Beato Leone Magno usque ad S.D.N. Benedictum XIV : opus absolutissimum Laertii Cherubini ... à D. Angelo Maria Cherubino ... cura & studio ... ; tomus sextus.

"Appendix ad tomum VI bullarii ... Alexandri VII, Clementis IX, Smi. D.N. Clementis X ..." con port. propia.

Vota decisiva a Francisco Maria Constantino nobili Asculano, celebratissimo juris utriusque consulto, ac Romanae Curiae advocato elucubrata in causis, in quibus ... vel definitivè pronunciavit, aùt in sensu veritatis respondit, nunc vero primum a J.U.D. Cosmo Mathia Constantino authoris pridem defuncti pronepote in lucem edita ... tomus I.

Mode of access: Internet.

Storio della Madre di Dio Maria Vergine Santissima del Monte Berico, del suo santo tempio, e d'altro di Vicenza.

Mode of access: Internet.

Ueber die politischen Programmschriften des Giuseppe Mazzini, Vincenzo Gioberti, Cesare Balbo und Massimo D'Azeglio : Beitrage zur Vorgeschichte der Bildung des neuen italienischen Konigreiches.

Thesis (doctoral)--Universitat Bern.

Ragguaglio del miracoloso avvenimento operato da Dio Nostro Signore per intercessione della gloriosa Vergine Maria, e del patriarca S. Giuseppe in persona del sig. D. Domenico di Mauro : tratto dalla di lui diposizione fatta avanti a' ministri della curia arcivescovile per ordine dell'eminentiss. e reverendiss. signor cardinal Pignatelli, arcivescovo di Napoli.

University of Illinois bookplate: "From the library of Conte Antonio Cavagna Sangiuliani di Gualdana Lazelada di Bereguardo, purchased 1921".

Teofrasto, Os caracteres. Introdução, tradução e notas de Maria Fátima Silva. Lisboa, Relógio d'Água, «Humanitas - autores gregos e latinos», 1999. [ISBN 972-708-531-8]

Sem resumo disponível.

Atenção ao idoso com diabetes mellitus na equipe saúde da família Maria de Lourdes Guimarães, no município de Pingo D'água, Minas Gerais

Apesar de a Diabetes Mellitus (DM) ser uma doença não transmissível, esta representa um grave problema de saúde pública no Brasil. A Atenção Básica, especificamente a Estratégia Saúde da Família, constitui-se para o desempenho do cuidado integral, da promoção à saúde e prevenção das complicações decorrentes dessa e de outras patologias. Diante desta realidade é premissa a discussão permanente sobre as práticas em saúde, utilizando-se de estratégias que permitam a reflexão fidedigna do processo de trabalho a ser executado. O presente estudo teve como objetivo sistematizar os cuidados aos portadores da diabetes Mellitus cadastrados na ESF Maria de Lourdes Guimarães no município de Pingo D��gua, Minas Gerais. Foi realizada uma revisão de literatura narrativa proporcionando maior conhecimento sobre tema do presente trabalho. Após ser realizado um diagnóstico situacional da referida ESF, considerou-se de fundamental importância e urgência ampliar os cuidados aos portadores de Diabetes da ESF. A DM acomete 4,74% da população cadastrada na área abrangente da Equipe Saúde da Família Maria de Lourdes Guimarães, no município de Pingo D��gua, Minas Gerais, sendo um total de 93 portadores da patologia. Vale ressaltar que, mesmo estando dentro da estimativa preconizada pelo Ministério da Saúde, que é 7%, este índice ainda representa para a área de abrangência um número significativo, considerando as consequências danosas oriundas deste mal. É necessária, portanto, a intervenção através da elaboração de um Plano de Ação para prevenção às complicações decorrentes desta patologia, e melhorar a qualidade de vida dos diabéticos idosos.

Unfavorable Outcomes During Treatment Of Multiple Sclerosis With High Doses Of Vitamin D.

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The effects of the experimental onfection from a focus of transmissopn of Schistosoma mansoni in a population of Biomphalaria tenagophila (D'Orbigny, 1835) in the region of "Vale do Ribeira de Iguape", Brazil

Com objetivo de observar os efeitos da infecção parasitária na biologia de B. tenagophila, foram realizadas infecções experimentais em populações de campo e laboratório, ambas procedentes de Itariri, Vale do Ribeira, Brasil. Cada molusco recebeu 10 miracídios de Schistosoma mansoni (linhagem SJ), sendo observado durante o desenvolvimento dos parasitos. As variáveis biológicas foram comparadas segundo os critérios "grupo" e "fase de infecção". Os principais danos decorrentes do parasitismo se manifestaram na reprodução, na longevidade e em lesões na concha dos moluscos na fase patente. Foi encontrada uma taxa de infecção de 58,8 por cento. O estudo microanatômico da glândula digestiva e do ovoteste do molusco revelou a presença de formas larvárias em evolução e cercárias. Concluiu-se que os efeitos da infecção parasitária, sobre as duas populações, foram moderados, uma vez que os danos não impediram a reprodução e a eliminação de cercárias que se manteve por um longo período, apesar da baixa sobrevivência dos moluscos parasitados

Deficiência em micronutrientes em mudas de sangra d'agua (Croton urucurana, Baill.)

This study had the following objectives: to induce and describe symptoms of deficiency of boron (B), copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo) and zinc (Zn), determining the effect on the mineral composition of leaves. The experiment was developed in a green house and used diagnosis technique by subtraction. The experimental design usedn was a randomized blocks, with seven treatments and three replicates. It was verified that micronutrient omission led to morphological alterations which, in turn, caused visual symptoms. The symptoms caused by the omission of Cu, Mn and Zn were the first to appear, and were followed by those of B, Fe and Mo. The omission of B, Mn and Zn was responsible for the more pronounced reduction in height and stem diameter.

Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E-2 and D-2 and expression of cyclooxygenases

The effects of myotoxin III (MT-III), a phospholipase A(2) (sPLA(2)) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases (COXs) expression and biosynthesis of prostaglandins (PGs) were evaluated, together with the mechanisms involved in these effects. Upon intraperitoneal injection in mice, both sPLA(2)s promoted the synthesis of PGD(2) and PGE(2), with a different time-course. MT-III, but not CB, induced COX-2 expression by peritoneal leukocytes without modification on COX-1 constitutive expression, whereas CB increased the constitutive activity of COX-1. MT-III increased the enzymatic activity of COX-1 and COX-2. Similar effects were observed when these sPLA(2)s were incubated with isolated macrophages, evidencing a direct effect on these inflammatory cells. Moreover, both toxins elicited the release of arachidonic acid from macrophages in vitro. inhibition of cPLA(2) by AACOCF(3), but not of iPLA(2) by PACOCF(3) or BEL, significantly reduced PGD2, PGE2 and arachidonic acid (AA) release promoted by MT-III. These inhibitors did not affect MT-III-induced COX-2 expression. In contrast, cPLA2 inhibition did not modify the effects of CB, whereas iPLA2 inhibition reduced PGD2 and AA production induced by CB. These findings imply that distinct regulatory mechanisms leading to PGs` synthesis are triggered by these snake venom sPLA(2)s. Such differences are likely to explain the dissimilar patterns of inflammatory reaction elicited by these sPLA(2)s in vivo. (C) 2008 Elsevier Ltd. All rights reserved.

Paracoccin from Paracoccidioides brasiliensis; purification through affinity with chitin and identification of N-acetyl-beta-D-glucosaminidase activity

The dimorphic fungus Paracoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, the most frequent systemic mycosis in Latin America. Our group has been working with paracoccin, a P. brasiliensis lectin with MM 70 kDa. which is purified by affinity, with immobilized N-acetylglucosamine (GlcNAc). Paracoccin has been described to play a role in fungal adhesion to extracellular matrix components and to induce high and persistent levels or TNF alpha. and nitric oxide production by macrophages. In the cell wall, paracoccin colocalizes with the beta-1,4-homopolymer of GlcNAc into the budding sites of the P. brasiliensis yeast cell. In this paper we present a protocol for the chitin-affinity purification or paracoccin. This procedure provided higher yields than those achieved by means of the technique based oil the affinity of this lectin with GlcNAc and had an impact on downstream assays. SDS-PAGE and Western blot analysis revealed similarities between the N-acetylglucosamine- and chitin-bound fractions, confirmed by MALDI-TOF-MS of trypsinic peptides. Western blot of two-dimensional gel electrophoresis of the yeast extract showed a major spot with M(r) 70000 and pl approximately 5.63. Moreover, an N-acetyl-beta-D-glucosaminidase activity was reported for paracoccin, thereby providing new insights into the mechanisms that lead to cell wall remodelling and opening new perspectives for its structural characterization. Copyright (C) 2009 John Wiley & Sons. Ltd.

Conditioned fear is modulated by D(2) receptor pathway connecting the ventral tegmental area and basolateral amygdala

Excitation of the mesocorticolimbic pathway, originating from dopaminergic neurons in the ventral tegmental area (VTA), may be important for the development of exaggerated fear responding. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. The functional role of the dopaminergic pathway connecting the VIA to the basolateral amygdala (BLA) in fear and anxiety has received little attention. In vivo microdialysis was performed to measure dopamine levels in the BLA of Wistar rats that received the dopamine D(2) agonist quinpirole (1 mu g/0.2 mu l) into the VTA and were subjected to a fear conditioning test using a light as the conditioned stimulus (CS). The effects of intra-BLA injections of the D(1) antagonist SCH 23390 (1 and 2 mu g/0.2 mu l) and D(2) antagonist sulpiride (1 and 2 mu g/0.2 mu l) on fear-potentiated startle (FPS) to a light-CS were also assessed. Locomotor performance was evaluated by use of open-field and rotarod tests. Freezing and increased dopamine levels in the BLA in response to the CS were both inhibited by intra-VTA quinpirole. Whereas intra-BLA SCH 23390 did not affect FPS, intra-BLA sulpiride (2 mu g) inhibited FPS. Sulpiride`s ability to decrease FPS cannot be attributed to nonspecific effects because this drug did not affect motor performance. These findings indicate that the dopamine D(2) receptor pathway connecting the ventral tegmental area and the basolateral amygdala modulates fear and anxiety and may be a novel pharmacological target for the treatment of anxiety. (C) 2010 Elsevier Inc. All rights reserved.

Low bone mass in juvenile onset sclerosis systemic: the possible role for 25-hydroxyvitamin D insufficiency

Juvenile onset systemic sclerosis (JoSSc) is a rare disease, and there are no studies focusing in bone mineral density and biochemical bone parameters. Ten consecutive patients with JoSSc and 10 controls gender, age, menarche age, and physical activity matched were selected. Clinical data were obtained at the medical visit and chart review. Laboratorial analysis included autoantibodies, 25-hydroxyvitamin D (25OHD), intact parathyroid hormone, calcium, phosphorus, alkaline phosphatase and albumin sera levels. Bone mineral density was analyzed by dual-energy X-ray absorptiometry, and bone mineral apparent density (BMAD) was calculated. A lower BMAD in femoral neck (0.294 +/- A 0.060 vs. 0.395 +/- A 0.048 g/cm(3), P = 0.001) and total femur (0.134 +/- A 0.021 vs. 0.171 +/- A 0.022 g/cm(3), P = 0.002) was observed in JoSSc compared to controls. Likewise, a trend to lower BMAD in lumbar spine (0.117 +/- A 0.013 vs. 0.119 +/- A 0.012 g/cm(3), P = 0.06) was also found in these patients. Serum levels of 25OHD were significantly lower in JoSSc compared to controls (18.1 +/- A 6.4 vs. 25.1 +/- A 6.6 ng/mL, P = 0.04), and all patients had vitamin D insufficiency (< 20 ng/mL) compared to 40% of controls (P = 0.01). All other biochemical parameters were within normal range and alike in both groups. BMAD in femoral neck and total femur was correlated with 25OHD levels in JoSSc (r = 0.82, P = 0.004; r = 0.707, P = 0.02; respectively). We have identified a remarkable high prevalence of 25OHD insufficiency in JoSSc. Its correlation with hip BMAD suggests a causal effect and reinforces the need to incorporate this hormone evaluation in this disease management.