Dernier Conseil suprême, 9-1-20, [Hugh Wallace], Lloyd George, Bonar Law [Paris, ministère des Affaires étrangères] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57551

ABD e-News - April 9, 2004

Weekly Newsletter

Lottery Action, February 9-22, 2004, Vol. 11, no. 3

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, May 3-16, 2004, Vol. 11, no. 9

Iowa Lottery Authority Retailer Information Newsletter

La voix de M. Léon Bourgeois, Président du Conseil des ministres : discours prononcé le 9 novembre 1917. La voix de M. Gaston Doumergue, Président du Conseil des ministres : discours prononcé le 5 septembre 1916

Collection : Série des documents historiques

ABD e-News July 9, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division

Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: implications for dermatitis.

Fas ligand (FasL) causes apoptosis of epidermal keratinocytes and triggers the appearance of spongiosis in eczematous dermatitis. We demonstrate here that FasL also aggravates inflammation by triggering the expression of proinflammatory cytokines, chemokines, and adhesion molecules in keratinocytes. In HaCaT cells and in reconstructed human epidermis (RHE), FasL triggered a NF-kappaB-dependent mRNA accumulation of inflammatory cytokines (tumor necrosis factor-alpha, IL-6, and IL-1beta), chemokines (CCL2/MCP-1, CXCL1/GROalpha, CXCL3/GROgamma, and CXCL8/IL-8), and the adhesion molecule ICAM-1. Oligomerization of Fas was required both for apoptosis and for gene expression. Inhibition of caspase activity abolished FasL-dependent apoptosis; however, it failed to suppress the expression of FasL-induced genes. Additionally, in the presence of caspase inhibitors, but not in their absence, FasL triggered the accumulation of CCL5/RANTES (regulated on activation normal T cell expressed and secreted) mRNA. Our findings identify a novel proinflammatory role of FasL in keratinocytes that is independent of caspase activity and is separable from apoptosis. Thus, in addition to causing spongiosis, FasL may play a direct role in triggering and/or sustaining inflammation in eczemas.

Lottery Action, August 9-22, 2004, Vol. 11, no. 15

Iowa Lottery Authority Retailer Information Newsletter

The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.

The level of intracellular proteins is mainly regulated through modifications by ubiquitin ligases that target them for degradation. Members of the NEDD4 family of E3 ubiquitin ligases, such as Itch (atrophin-1 interacting protein 4), possess up to four WW domains for specific association with PY motif-containing substrates. We have identified sorting nexin 9 (SNX9), a protein involved in endocytic processes, as a new substrate of Itch. Itch ubiquitylates SNX9 and regulates intracellular SNX9 levels. Using truncated proteins, we found that the interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9. Interaction with the PRD of Itch is essential for SNX9 ubiquitylation and degradation. Furthermore, this effect is specific for Itch, as NEDD4, a related PRD-containing E3 ligase, does not bind SNX9. SNX18, a second member of the SNX family containing an SH3 domain, was also found to bind to Itch. Our results indicate that the pool of substrates of NEDD4 family E3 ubiquitin ligases extends beyond proteins containing PY motifs.

Histoire du dix-neuvième siècle depuis les traités de Vienne. Tome 9 / G. G. Gervinus,... ; traduit de l'allemand par J.-F. Minssen,...

Collection : Collection d'historiens contemporains

Credit Union Division Activities, December 2003, Issue 9

Newsletter for Iowa Credit Union Division

Footnotes, September-October 2004, Vol. 28, no. 9-10

Monthly newsletter of the State Library

Footnotes, July/August 2004, Vol. 28, no. 7-9

Monthly newsletter of the State Library

Lottery Action, August 23-September 9, 2004, Vol. 11, no. 16

Iowa Lottery Retailer Newsletter