Characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in North America.

The silver-haired bat variant of rabies virus (SHBRV) has been identified as the etiological agent of a number of recent human rabies cases in the United States that are unusual in not having been associated with any known history of conventional exposure. Comparison of the different biological and biochemical properties of isolates of this virus with those of a coyote street rabies virus (COSRV) revealed that there are unique features associated with SHBRV. In vitro studies showed that, while the susceptibility of neuroblastoma cells to infection by both viruses was similar, the infectivity of SHBRV was much higher than that of COSRV in fibroblasts (BHK-21) and epithelial cells (MA-104), particularly when these cells were kept at 34 degrees C. At this temperature, low pH-dependent fusion and cell-to-cell spread of virus is seen in BHK-21 cells infected with SHBRV but not with COSRV. It appears that SHBRV may possess an unique cellular tropism and the ability to replicate at lower temperature, allowing a more effective local replication in the dermis. This hypothesis is supported by in vivo results which showed that while SHBRV is less neurovirulent than COSRV when administered via the intramuscular or intranasal routes, both viruses are equally neuroinvasive if injected intracranially or intradermally. Consistent with the above findings, the amino acid sequences of the glycoproteins of SHBRV and COSRV were found to have substantial differences, particularly in the region that contains the putative toxic loop, which are reflected in marked differences in their antigenic composition. Nevertheless, an experimental rabies vaccine based on the Pittman Moore vaccine strain protected mice equally well from lethal doses of SHBRV and COSRV, suggesting that currently used vaccines should be effective in the postexposure prophylaxis of rabies due to SHBRV.

Trapping of branched DNA in microfabricated structures.

We have observed electrostatic trapping of tribranched DNA molecules undergoing electrophoresis in a microfabricated pseudo-two-dimensional array of posts. Trapping occurs in a unique transport regimen in which the electrophoretic mobility is extremely sensitive to polymer topology. The arrest of branched polymers is explained by considering their center-of-mass motion; in certain conformations, owing to the constraints imposed by the obstacles a molecule cannot advance without the center of mass first moving a short distance backwards. The depth of the resulting local potential well can be much greater than the thermal energy so that escape of an immobilized molecule can be extremely slow. We summarize the expected behavior of the mobility as a function of field strength and topology and point out that the microfabricated arrays are highly suitable for detecting an extremely small number of branched molecules in a very large population of linear molecules.

Kitāb Soḥbat ōrang ber-dōsa: [The friend of sinners; a collection of pious tracts in the Malay language]

Lithographed.

Kitāb Tuḥfat ahl al-futūḥāt wa-al-adhwāq fī ittikhādh al-subḥah wa-jaʻlihā fī al-aʻnāq wa-baʻḍ al-ādāb al-lāʼiqah bi-al-mukarramīn bi-ṣuḥbat ahl ḥaḍrat al-iṭlāq bi-faḍl al-karīm al-khallāq

lil-Shaykh Fatḥ Allāh ibn al-Shaykh Sayyidī Abī Bakr al-Bannānī.

Hādhihi awāʼil khuṭbat Tafsīr al-Baghawī : manuscript, [ca. 1567]

Bound with: Hādhihi qaṣīdah al-musammāh bi-Lāmīyat al-ʻajam / lil-Ṭughrāʼī.

Polyurethane foam as trapping agent for airborne pesticides : analytical method development /

"Interagency agreement no. 78-D-XO449."

Canadian wilds : tells about the Hudson's Bay Company, northern Indians and their modes of hunting, trapping, etc. /

Mode of access: Internet.

Historical sketch of the Flathead Indian nation from the year 1813 to 1890. Embracing the history of the establishment of St. Mary's Indian mission in the Bitter Root Valley, Mont. With sketches of the missionary life of Father Ravalli and other early missionaries, wars of the Blackfeet and Flatheads, and sketches of history, trapping and trading in the early days ...

Mode of access: Internet.

Iosephi Scaligeri Iul. Caes. f. De re nummaria dissertatio, Liber posthumus: ex bibliotheca Academiae Lugd. Bat.

Mode of access: Internet.

R.P. Ioan. Bat. de Expectatione, Vallisoletani, ordinis Excalceatorum Sanctissimae Trinitatis, Minerale concionum : in quo sacer textus, unde sumuntur sermones aduentus, [et] à dominica in septuagesima vsque ad dominicam in albis, fuse exponitur.

Mode of access: Internet.

The bat and the ball; or, Negative evidence, a farce in one act,

Mode of access: Internet.

Kitāb iḥyāʾ al-qulūb sharḥ al-imām al-ʻārif billāh taʻālah ʻUmdat al-wāṣilīn wa-kaʻbat al-sālikīn yanbūʻ ʻilm al-ḥaqīqah wa-al-dīn mawlānā al-Shaykh ʻAbd al-Qādir al-Rāfiʻī al-Fārūqī al-Ṭarābulusī ʻalá ḥukum shaykhihi waliya Allāh ṣāḥib al-karāmāt al-ḍhāhirah wa-al-ishārāt al-bāhirah Sayyidī Maḥmūd al-Khallūtī.

Mode of access: Internet.

Hādhā Kitāb al-Lumʻah al-bayḍāʼ fī sharḥ khuṭbat al-Zahrāʼ[microform]

Caption title.