Illicit drug use, alcohol use and nicotine dependence as predictors of antiretroviral adherence in a sample of HIV positive smokers

Objective. Predictors of non-adherence to antiretroviral medications in a population of low-income, multiethnic, HIV-positive smokers were investigated. ^ Methods. A secondary analysis was conducted using baseline data collected from 326 patients currently prescribed antiretrovirals enrolled in a randomized clinical trial assessing smoking outcomes. Variables evaluated included demographics, stress, depression, nicotine dependence, illicit drug use and alcohol use. ^ Results. The average age of participants was 45.9 years (SD=7.6). The majority of participants were male (72.1%), Black (76.7%), reported sexual contact as the method of HIV exposure (heterosexual (43%) and MSM (27%)) and were antiretroviral adherent (60.4%). Results from unadjusted analyses indicated depression (OR=1.02; 95% CI=1.00-1.04), illicit drug use (OR=2.39; 95% CI=1.51-3.79) and alcohol consumption (OR=2.86; 95% CI=1.79-4.57) were associated with non-adherence. Multivariate analyses indicated nicotine dependence (OR=1.13; 95% CI=1.02-1.25), illicit drug use (OR=2.10; 95% CI=1.27-3.49) and alcohol use (OR=2.50; 95% CI=1.52-4.12) were associated with nonadherence. ^ Conclusions. Illicit drug use, alcohol use and nicotine dependence are formidable barriers to antiretroviral adherence in this population. Future research is needed to assess how to address these variables in the context of improving antiretroviral adherence for individuals living with HIV/AIDS.^

Drug and alcohol testing results 1996 annual report.

Federal Transit Administration, Washington, D.C.

Drug and alcohol testing results 1997 annual report.

Federal Transit Administration, Washington, D.C.

Drug and alcohol testing results 1999 annual report.

Federal Transit Administration, Washington, D.C.

Drug and alcohol testing results 2001 annual report.

Statistics on employees returned to duty and results of return-to-duty tests and follow-up tests are presented separately from results of the other four test types because return-to-duty tests and follow-up tests represent a different segment of the test population and not all employers offer rehabilitation.

Public acceptability of highway safety countermeasures. Volume III: alcohol and drug research. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Review of legal literature--published between July 1974 and July 1978. Pertaining to alcohol and drug involvement in highway safety.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Safety, Washington, D.C.

Potential for application of corneal retinal potential measurements to detect alcohol and drug use: a report to Congress.

Mode of access: Internet.

Retired Senior Volunteer Program activities in alcohol and drug abuse prevention and education /

Mode of access: Internet.

Effect of alcohol and drug abuse on productivity : joint hearing before the Subcommittee on Alcoholism and Drug Abuse and the Subcommittee on Employment and Productivity of the Committee on Labor and Human Resources, United States Senate, Ninety-seventh Congress, second session, on to review employee assistance programs for alcohol and drug abuse problems in American industry and professions, July 14, 1982.

Mode of access: Internet.

Alcohol, drugs, and driving : hearing before the Subcommittee on Alcoholism and Drug Abuse of the Committee on Labor and Human Resources, United States Senate, Ninety-seventh Congress, second session, on to examine what effect alcohol and drugs have on individuals while driving, August 5, 1982.

Mode of access: Internet.

Advancing the agenda for recovery : specialized alcohol and drug treatment services for women : plan years 2007-2011.

"December 20, 2006."--Cover letter.

Alcohol, tobacco, and other drug use by women in the Illinois child welfare system : prevalence - treatment need - impact on children.

"This report represents a joint effort between the Illinois Department of Alcoholism and Substance Abuse (DASA) and Department of Children and Family Services (DCFS). The study examined alcohol, tobaccco, and other drug abuse (ATODA) and need for treatment among adults involved with the child welfare system in Illinois. The purpose of the study was to provide data on the relationships between ATODA and child abuse and neglect"--P. iii.

Alcohol and drug abuse among the elderly : an annotated bibliography /

"September 1979."

Combined alcohol or drug-related hospital discharges in Illinois for 1988 and 1990 /

"July 1992."