DIVINDADES MLK E CULTO A MOLEK NOS QUADROS DA CRISE RELIGIOSA NO FINAL DA MONARQUIA DE JUDÁ (2 Reis 16,3; 17,17.31; 21,6; 23,10; KTU 1.100; 1.118; 1.161)

A dissertação é dirigida a um especial e não resolvido problema na descrição do desenvolvimento religioso de Israel. Em textos do Antigo Testamento acerca do sacrifício de humanos, há uma unidades literárias autônomas relacionadas ao culto a mOlek. Porém, alguns pesquisadores sustentam que o culto a mOlek não tem esta característica. A dissertação aspira a investigar este argumento, concentrando-se em fontes históricas (2Reis 16,3; 17,17.31; 21,6; 23,10). Discutindo fontes ugaríticas duas listas de divindades e um texto funerário nós perguntares acerca das características das divindades mLlK nas culturas cananéias. Em síntese, mOlek é uma divindade ctônica mas não é destinatária de sacrifícios humanos.(AU)

DIVINDADES MLK E CULTO A MOLEK NOS QUADROS DA CRISE RELIGIOSA NO FINAL DA MONARQUIA DE JUDÁ (2 Reis 16,3; 17,17.31; 21,6; 23,10; KTU 1.100; 1.118; 1.161)

A dissertação é dirigida a um especial e não resolvido problema na descrição do desenvolvimento religioso de Israel. Em textos do Antigo Testamento acerca do sacrifício de humanos, há uma unidades literárias autônomas relacionadas ao culto a mOlek. Porém, alguns pesquisadores sustentam que o culto a mOlek não tem esta característica. A dissertação aspira a investigar este argumento, concentrando-se em fontes históricas (2Reis 16,3; 17,17.31; 21,6; 23,10). Discutindo fontes ugaríticas duas listas de divindades e um texto funerário nós perguntares acerca das características das divindades mLlK nas culturas cananéias. Em síntese, mOlek é uma divindade ctônica mas não é destinatária de sacrifícios humanos.(AU)

Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex

Cortical blood flow at the level of individual capillaries and the coupling of neuronal activity to flow in capillaries are fundamental aspects of homeostasis in the normal and the diseased brain. To probe the dynamics of blood flow at this level, we used two-photon laser scanning microscopy to image the motion of red blood cells (RBCs) in individual capillaries that lie as far as 600 μm below the pia mater of primary somatosensory cortex in rat; this depth encompassed the cortical layers with the highest density of neurons and capillaries. We observed that the flow was quite variable and exhibited temporal fluctuations around 0.1 Hz, as well as prolonged stalls and occasional reversals of direction. On average, the speed and flux (cells per unit time) of RBCs covaried linearly at low values of flux, with a linear density of ≈70 cells per mm, followed by a tendency for the speed to plateau at high values of flux. Thus, both the average velocity and density of RBCs are greater at high values of flux than at low values. Time-locked changes in flow, localized to the appropriate anatomical region of somatosensory cortex, were observed in response to stimulation of either multiple vibrissae or the hindlimb. Although we were able to detect stimulus-induced changes in the flux and speed of RBCs in some single trials, the amplitude of the stimulus-evoked changes in flow were largely masked by basal fluctuations. On average, the flux and the speed of RBCs increased transiently on stimulation, although the linear density of RBCs decreased slightly. These findings are consistent with a stimulus-induced decrease in capillary resistance to flow.

Dopamine inhibits mammalian photoreceptor Na+,K+-ATPase activity via a selective effect on the alpha3 isozyme.

The rat retina contains dopaminergic interplexiform cells that send processes to the outer plexiform layer where dopamine is released in a light-dependent manner. We report herein that physiologically relevant concentrations of dopamine inhibited ouabain-sensitive photoreceptor oxygen consumption in dark- and light-adapted rat retinas and inhibited Na+,K+-ATPase specific activity (EC 3.6.1.37) in a rat rod outer-inner segment preparation. Experiments with the selective D1 agonist fenoldopam or D2 agonist quinpirole and experiments with dopamine plus either the D1 antagonist SCH23390 or D2/D4 antagonist clozapine showed that the inhibition of oxygen consumption and enzyme activity were mediated by D2/D4-like receptors. The amphetamine-induced release of dopamine, monitored by the inhibition of oxygen consumption, was blocked by L-2-amino-4-phosphonobutyric acid and kynurenic acid. Pharmacological and biochemical experiments determined that the IC50 values of ouabain for the alpha1-low and alpha3-high ouabain affinity isozymes of photoreceptor Na+,K+-ATPase were approximately 10(-5) and approximately 10(-7) M, respectively, and that the D2/D4-like mediated inhibition of Na+,K+-ATPase was exclusively selective for the alpha3 isozyme. The dopamine-mediated inhibition of alpha3 first occurred at 5 nM, was maximal at 100 microM (-47%), had an IC50 value of 382 +/- 23 nM, and exhibited negative cooperativity (Hill coefficient, 0.27). Prior homogenization of the rod outer-inner segment completely prevented the long-lasting inhibition, suggesting that the effect was coupled to a second messenger. Although the physiological significance of our findings to photoreceptor function is unknown, we hypothesize that these results may have relevance for the temporal tuning properties of rods.

Manhattan, New York, N.Y., 1834 (Raster Image) (Image 2 of 4)

This layer is a georeferenced raster image of the historic paper map entitled: The city of New York drawn from actual surveys as furnished by the several city surveyors. It was printed in 1834 by Pendleton, lithographer. Scale [ca. 1:2,350]. Covers Manhattan below 24th St. This layer is image 2 of 4 total images of the four sheet source map, representing the northeast portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, selected public buildings, banks, markets, churches, schools, colleges, city wards, parks, ferry lines, wharves, original shoreline, and more. Includes index to points of interest. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Mississippi River survey, New Orleans, Louisiana, 1895 (Image 2 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Survey of the Mississippi River : made under the direction of the Mississippi River Commission : chart no. 76, projected from a trigonometrical survey made by the U.S. Coast survey in 1874. It was published by the Mississippi River Commission ca. 1895. Scale 1:10,000. Covers the City of New Orleans and adjacent portions of Jefferson and St. Bernard Parishes. This layer is image 2 of 4 total images of the four sheet source map, representing the southeast portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Louisiana State Plane Coordinate System, South NAD83 (in Feet) (Fipszone 1702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, canals, drainage, vegetation/ground cover, land ownership in outlying areas, selected public, private, and industrial buildings, parks, cemeteries, Parish boundaries, ferry routes and more. Relief shown by contours. Detailed depths of the Mississippi River shown with soundings and dates of survey, and survey control points. River banks and bottom soil types shown. Includes index chart, list of authorities, and notes. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Milwaukee and vicinity, Wisconsin, 1962 (Image 2 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic, topographic paper map entitled: Milwaukee and vicinity, Wisconsin, 1959, mapped, edited and published by the Geological Survey. It was published by U.S. Dept. of the Interior, Geological Survey in 1962. Scale 1:24,000. Compiled from 1:24,000-scale maps of Thiensville, Menomonee Falls, Wauwatosa, Milwaukee, South Milwaukee, Greendale 1958, and Hales Corners 1959 7.5 minute quadrangles. Selected hydrographic data compiled from U.S. Lake Survey Charts 74 and 743 (1957). This layer is image 2 of 4 total images of the four sheet source map representing the northeast portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Wisconsin South State Plane NAD 1927 coordinate system (Fipszone 4803). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This is a typical topographic map portraying both natural and manmade features. It shows and names works of nature, such as mountains, valleys, lakes, rivers, vegetation, etc. It also identify the principal works of humans, such as roads, railroads, boundaries, transmission lines, major buildings, etc. Relief shown by contours (interval 10 feet) and spot heights. Depths shown by contours and soundings. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.