Metáforas e intertextos de la enfermedad: suicidio y homoerotismo adolescente en las novelas Conquering Venus, de Collin Kelley y Suicide Notes, de Michael Thomas Ford

En el mundo cada cinco minutos se produce un suicidio en adolescentes por problemas inherentes a su sexualidad. Frente a este escenario la genealogía de los discursos médico, jurídico y literario se entreteje apretando los hilos, convirtiéndose en cábala del suicidio; un reflejo difuso de una realidad menos ficcional y más dolorosa. A pesar de las cifras alarmantes, no se ha trabajado el tema; menos aún con la perspectiva de encontrar relación entre los discursos históricos que en su búsqueda de poder y control han dibujado sobre los cuerpos, representaciones de una disciplina heterosexual. Es indispensable una perspectiva cualitativa, reflexiones que aporten a una práctica ética diferente, que incluya los nuevos cuerpos filosóficos, legales, concibiendo al adolescente como sujeto, con la agencia que deben tener sus cuerpos. En contraste en la literatura (¿mundo ficticio?) se describe y resignifica de manera exhaustiva esta realidad, rescatando la capacidad creativa y re-creativa del lenguaje. Esto por un lado permite analizar los contextos y coyunturas sociales, culturales; y, por otro interpretar los imaginarios sociales y las metáforas que refuerzan este contexto. Como mencionara Stuart Hall, a través de la representación conectamos el lenguaje al sentido y la cultura. Y esto nos licencia a referirnos al mundo real pero también a un mundo ficticio. Esta exploración pretende aportar a esta problemática mediante la descripción de esa compleja interseccionalidad y la identificación de posibles intersticios en el lenguaje que pudieran dar sentido y descodificar ciertas incertidumbres, contribuir a cambios micro sociales y, quizás, conducir a lo que pudiera ser el comienzo de un diálogo más amplio que empuje posicionamientos y cambios estructurales, frente a discursos vetustos que siempre encuentran mecanismos para reinventarse. ¿Cómo se representan y entretejen los discursos de homoerotismo1 adolescente y suicidio representados en las novelas Conquering Venus de Collin Kelley, Suicide Notes de Michael Thomas Ford? Lo podremos averiguar examinando las matrices discursivas del homoerotismo y su castigo, la homosexualidad; analizando el suicidio como un acto humano complejo, incomprensible, un tabú en nuestra sociedad, e identificando en las novelas escogidas, las intersecciones entre homoerotismo y tendencias suicidas en el cuerpo adolescente.

Enfermedad mental, crimen y dignidad humana. Un estudio sobre la «medida de seguridad» en Brasil

¿La «medida de seguridad» en Brasil actúa como un instrumento de violación de la dignidad de las personas que cometieron crímenes y que sufren algún trastorno mental? Para contestar esta pregunta, la obra empieza por analizar las tensiones existentes entre las concepciones sobre la locura, y expone los modelos de control social que justificaron la historia de segregación de estos sujetos. La dignidad humana, en esta investigación, se articula a partir de la concepción individualista de Kant y de la relacional de Hannah Arendt, estableciendo una base teórica donde ambas dimensiones de dignidad se complementan para conseguir el desarrollo pleno, el reconocimiento y el respeto de la dignidad humana en el ámbito jurídico. La obra problematiza, además, la visión teórico-dogmática detrás de la medida de seguridad como mecanismo de control en el derecho penal, y analiza críticamente su aplicación en contrapunto con el respeto a los derechos humanos. Finalmente, estudia el parámetro jurídico para el tratamiento digno a los enfermos mentales autores de delito, a partir de las normas de los sistemas global e interamericano de protección de los derechos humanos, de las disposiciones de la Constitución brasileña, de las normas pertinentes de ese país, de la jurisprudencia del órgano de control constitucional, el Supremo Tribunal Federal de Brasil, además del aporte de la Corte Constitucional de Colombia.

Molecular inventory of faecal microflora in patients with Crohn's disease

Intestinal microbial community is involved in the pathogenesis of Crohn's disease, but knowledge of its potential abnormalities has been limited by the impossibility to grow many dominant intestinal bacteria. Using sequence analysis of randomly cloned bacterial 16S ribosomal DNA, the dominant faecal species from four Crolin's disease patients and four controls were compared. Whereas marked inter-individual differences were observed in the faecal microflora of patients, three remained distantly related to controls on the basis of their operational taxonomic unit composition. Bacteroides vidgatus and closely related organisms represented the only molecular species shared by all patients and exhibited an unusually high rate of occurrence. Escherichia coli clones were isolated only in two patients with ileocolonic Crohn's disease. Moreover, numerous clones belonged to phylogenetic groups or species that are commonly not dominant in the faecal microflora of healthy subjects: Pectinatus, Sutterella, Verritcomicrobium, Fusobacterium, Clostridium disporicum, clostridium glycolicum, Clostridium ramosum, Clostridium innocuum and Clostridium perfringens. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an in vitro approach using a continuous culture colonic model system.

Rifaximin, a rifamycin derivative, has been reported to induce clinical remission of active Crohn's disease (CD), a chronic inflammatory bowel disorder. In order to understand how rifaximin affects the colonic microbiota and its metabolism, an in vitro human colonic model system was used in this study. We investigated the impact of the administration of 1800 mg/day of rifaximin on the faecal microbiota of four patients affected by colonic active CD [Crohn's disease activity index (CDAI > 200)] using a continuous culture colonic model system. We studied the effect of rifaximin on the human gut microbiota using fluorescence in situ hybridization, quantitative PCR and PCR–denaturing gradient gel electrophoresis. Furthermore, we investigated the effect of the antibiotic on microbial metabolic profiles, using 1H-NMR and solid phase microextraction coupled with gas chromatography/mass spectrometry, and its potential genotoxicity and cytotoxicity, using Comet and growth curve assays. Rifaximin did not affect the overall composition of the gut microbiota, whereas it caused an increase in concentration of Bifidobacterium, Atopobium and Faecalibacterium prausnitzii. A shift in microbial metabolism was observed, as shown by increases in short-chain fatty acids, propanol, decanol, nonanone and aromatic organic compounds, and decreases in ethanol, methanol and glutamate. No genotoxicity or cytotoxicity was attributed to rifaximin, and conversely rifaximin was shown to have a chemopreventive role by protecting against hydrogen peroxide-induced DNA damage. We demonstrated that rifaximin, while not altering the overall structure of the human colonic microbiota, increased bifidobacteria and led to variation of metabolic profiles associated with potential beneficial effects on the host.

Infliximab-induced psoriasis during therapy for Crohn's disease

Although therapy with tumor necrosis factor-alpha inhibitors (anti-TNF) provides beneficial effects in different immune inflammatory disorders, paradoxical cases of anti-THE-induced psoriasis have increasingly been reported, mostly in the setting of rheumatologic diseases. To date, less than 50 cases of infliximab-induced psoriasis in inflammatory bowel disease patients have been described. The present report was aimed at describing two new cases of infliximab-induced psoriasis during therapy for Crohn's disease and at carrying out a review on this intriguing phenomenon. (C) 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

Mucosa-associated but not luminal Escherichia coli is augmented in Crohn's disease and ulcerative colitis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influencia de la enfermedad periodontal en el control metabólico de pacientes con diabetes mellitus tipo 2: revisión de la literatura

There may be an interaction between periodontal disease and sonic systemic diseases such as diabetes mellitus The objective of this review was to verify by means of a review of clinical trials if is a positive association between periodontal disease and the glycerine control of type 2 diabetes mellitus (DM 2) patients Eleven articles that fit the study criteria were revised It was concluded that periodontal disease may influence the metabolic control of 2 Additional studies with larger sample sizes and longer follow up are necessary for a better clarification of this issue (Rev Med Chile 2010 138 1172 1178)

Síntomas depresivos y trastorno motor en pacientes con enfermedad de Parkinson

Introduction. Complex relations between brain and psychopathology have attracted the interest of researchers, aiming to clarify the neurobiological mechanisms of depression in Parkinson's disease, obviously in addiction to mental features. Aims. The association of motor impairment and decline of personal autonomy with severity of depressive symptoms was the hypothesis of the present study. Aiming to check this hypothesis, the objective of this study consisted in investigating relationships between the severity of depressive symptoms and motor characteristics of Parkinson's disease. Patients and methods. Thirty patients (53 to 80 year-old) with medical diagnosis of idiopathic Parkinson's disease in initial clinic stages were studied. The Unified Parkinson's Disease Rating Scale, Hoehn-Yahr Scale, and Schwab & England Scale were used to assess the clinic signs and symptoms. The depressive symptoms were identified by complete anamnesis, examination of mental condition, and the Hamilton Rating Scale for Depression and the Anxiety and Depression Scale. Statistical analysis was performed by Pearson's correlation and multiple regression analysis. Results. A significant correlation of severity of depression symptoms with disease stage (p < 0.02), with motor signs (p < 0.008), and with functional performance (p < 0.007) was found. Conclusion. There was significant association between motor impairment and severity of depressive symptoms, and between depression and early disease onset or prolonged duration of Parkinson's disease. © 2007, Revista de Neurología.

Influencia de la actividad física en la enfermedad de Alzheimer: un caso clínico

Alzheimer's dementia (AD) is a neurodegenerative disorder that causes motor and cognitive decline. The aim of this study was to analyze the influence of a specific physical activity program on the cognitive, depressive symptoms and functional capacity of patients with diagnosis of probable AD. The subject, a 79-year old woman, participated in this program for three months, with 50 min sessions three times a week. The instruments used were the Cambridge Cognitive Examination; the Geriatric Depression Scale; and the Battery of the American Alliance for Health Physical Education, Recreation and Dance. The results in relationship with the depressive symptoms and functional capacity were significantly positive. There were no changes in regards to the patient's cognitive functions. In conclusion, this physical activity program seems to be an important part of the treatment for patients with AD, as it improves the functional capacity and also stimulates cognitive tasks. © 2008 Asociación Española de Fisioterapeutas.

Anestesia para colecistectomía videolaparoscópica en paciente portador de enfermedad de Steinert. Relato de caso y revisiõn de la literatura

BACKGROUND AND OBJECTIVES: Myotonic dystrophies are autosomal dominant neuromuscular diseases. Among them, myotonic dystrophy type 1 (MD1), or Steinert disease, is the most common in adults, and besides muscular involvement it also has important systemic manifestations. Myotonic dystrophy type 1 poses a challenge to the anesthesiologist. Those patients are more sensitive to anesthetics and prone to cardiac and pulmonary complications. Besides, the possibility of developing malignant hyperthermia and myotonic episodes is also present. CASE REPORT: This is a 39-year old patient with DM1 who underwent general anesthesia for videolaparoscopic cholecystectomy. Total intravenous anesthesia with propofol, remifentanil, and rocuronium was the technique chosen. Intercurrences were not observed in the 90-minute surgical procedure, but after extubation, the patient developed respiratory failure and myotonia, which made tracheal intubation impossible. A laryngeal mask was used, allowing adequate oxygenation, and mechanical ventilation was maintained until full recovery of the respiratory function. The patient did not develop further complications. CONCLUSIONS: Myotonic dystrophy type 1 presents several particularities to the anesthesiologist. Detailed knowledge of its systemic involvement along with the differentiated action of anesthetic drugs in those patients will provide safer anesthetic-surgical procedure.

Aprovechar el auge exportador de productos básicos evitando la enfermedad holandesa

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Estimaciones indirectas de la prevalencia y mortalidad por enfermedad de Chagas, malaria y tuberculosis en Bolivia: dos aplicaciones a la evaluación de programas de salud

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Costa Rica: proyección de la población cubierta por el regimen de enfermedad y maternidad 1989-1998; trabajo final

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