Alterations of Endothelial Glycocalyx During Orthotopic Liver Transplantation in Patients With End-Stage Liver Disease.

BACKGROUND Endothelial glycocalyx participates in the maintenance of vascular integrity, and its perturbations cause capillary leakage, loss of vascular responsiveness, and enhanced adhesion of leukocytes and platelets. We hypothesized that marked shedding of the glycocalyx core protein, syndecan-1, occurs in end-stage liver disease (ESLD) and that it increases during orthotopic liver transplantation (OLT). We further evaluated the effects of general anesthesia on glycocalyx shedding and its association with acute kidney injury (AKI) after OLT. PATIENTS AND METHODS Thirty consecutive liver transplant recipients were enrolled in this prospective study. Ten healthy volunteers served as a control. Acute kidney injury was defined by Acute Kidney Injury Network criteria. RESULTS Plasma syndecan-1 was significantly higher in ESLD patients than in healthy volunteers (74.3 ± 59.9 vs 10.7 ± 9.4 ng/mL), and it further increased significantly after reperfusion (74.3 ± 59.9 vs 312.6 ± 114.8 ng/mL). The type of general anesthesia had no significant effect on syndecan-1. Syndecan-1 was significantly higher during the entire study in patients with posttransplant AKI stage 2 or 3 compared to patients with AKI stage 0 or 1. The area under the curve of the receiver operating characteristics curve of syndecane-1 to predict AKI stage 2 or 3 within 48 hours after reperfusion was 0.76 (95% confidence interval, 0.57-0.89, P = 0.005). CONCLUSIONS Patients with ESLD suffer from glycocalyx alterations, and ischemia-reperfusion injury during OLT further exacerbates its damage. Despite a higher incidence of AKI in patients with elevated syndecan-1, it is not helpful to predict de novo AKI. Volatile anesthetics did not attenuate glycocalyx shedding in human OLT.

The longitudinal impact of self-efficacy and career goals on objective and subjective career success

The present research reports on the impact of occupational self-efficacy and of career-advancement goals on objective (salary, status) and subjective (career satisfaction) career attainments. Seven hundred and thirty four highly educated and full-time employed professionals answered questionnaires immediately after graduation, three years later, and seven years later. Controlling for discipline, GPA at master’s level, and gender, we found that occupational self-efficacy measured at career entry had a positive impact on salary and status three years later and a positive impact on salary change and career satisfaction seven years later. Career-advancement goals at career entry had a positive impact on salary and status after three years and a positive impact on status change after seven years, but a negative impact on career satisfaction after seven years. Women earned less than men, but did not differ from men in hierarchical status and in career satisfaction. Theoretical implications for socio-cognitive theorizing and for career-success research as well as applied implications for vocational behavior are discussed.

Sonate pour le piano-forte avec accompagnement de flûte ou violon obligé op. 74

composé par M. Henkel

Ms. hebr. oct. 74 - [Sammelband in 4 Teilen: Handschriftenkonvolut]

Vorbesitzer: Abraham Merzbacher

Ms. Barth. 74 - Postilla in evangelium Lucae, C.X-XXIV

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Operative Treatment of Acute Fractures of the Tarsal Navicular Body: Midterm Results With a New Classification.

BACKGROUND Treatment of displaced tarsal navicular body fractures usually consists of open reduction and internal fixation. However, there is little literature reporting results of this treatment and correlation to fracture severity. METHODS We report the results of 24 patients treated in our institution over a 12-year period. Primary outcome measurements were Visual-Analogue-Scale Foot and Ankle score (VAS-FA), AOFAS midfoot score, and talonavicular osteoarthritis at final follow-up. According to a new classification system reflecting talonavicular joint damage, 2-part fractures were classified as type I, multifragmentary fractures as type II, and fractures with talonavicular joint dislocation and/or concomitant talar head fractures as type III. Spearman's coefficients tested this classification's correlation with the primary outcome measurements. Mean patient age was 33 (range 16-61) years and mean follow-up duration 73 (range 24-159) months. RESULTS Average VAS-FA score was 74.7 (standard deviation [SD] 16.9), and average AOFAS midfoot score was 83.8 (SD = 12.8). Final radiographs showed no talonavicular arthritis in 5 patients, grade 1 in 7, grade 2 in 3, grade 3 in 6, and grade 4 in 1 patient. Two patients had secondary or spontaneous talonavicular fusion. Spearman coefficients showed strong correlation of the classification system with VAS-FA score (r = -0.663, P < .005) and talonavicular arthritis (r = 0.600, P = .003), and moderate correlation with AOFAS score (r = -.509, P = .011). CONCLUSION At midterm follow-up, open reduction and internal fixation of navicular body fractures led to good clinical outcome but was closely related to fracture severity. A new classification based on the degree of talonavicular joint damage showed close correlation to clinical and radiologic outcome. LEVEL OF EVIDENCE Level IV, retrospective case series.

Petition des Friedrich-Wilhelmsstädtischen Bezirks-Vereins (Stadtbezirke 74. a. b.c.) an die Hohe Versammlung der Volksvertreter: Schon von mehreren Seiten sind die Vertreter des Volks an ihre Schuld gegen die Kämpfer der Märztage gemahnt worden ...

Welsch (Projektbearbeiter): Petition an die Preußische Nationalversammlung, den Kämpfern des 18. und 19. März 1848 den Dank des preußischen Volkes auszusprechen, für die Invaliden und Hinterbliebenen jener Tage zu sorgen, den Gefallenen ein Denkmal zu errichten und die fraglichen Tage zu politischen Feiertagen zu erklären

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 74 - Bericht über den Aufenthalt auf der Insel Pelew

Abschrift liegt vor;

Ms. Praed. 74 - Sermones et tractatus de beata Maria virgine

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ms.Ff.F.Stoltze 3. 74 - Brief von Alexander Giesen von Frankfurter Journalisten- und Schriftsteller-Verein an Lydia Lerner-Stoltze

Stoltze-Gedenkfeier

Na 1 Nachlass Max Horkheimer, 74 - Korrespondenzen u.a. mit Käte von Hirsch (p. II 8, 232-369)

1 Brief von F. Pollock an Frederick J. Hacker, 1945; 1 Brief von Frederick J. Hacker an Max Horkheimer, sowie 2 Memoranden von Max Horkheimer; 5 Briefe zwischen Willy Hartner und Max Horkheimer, 1948; 3 Briefe und eine Drucksache von Fred Herzberg an Max Horkheimer, 1947; 1 Brief und 3 Memoranden von Max Horkheimer an Fred Herzberg, 1947; 2 Briefe von Heinz Herald an Max Horkheimer, 1946 sowie 1 Gutachten und Beilage von Max Horkheimer an Heinz Herald, 1946; 2 Briefe zwischen Josef Haurand und Max Horkheimer, 1949, 1950; 3 Briefe und Beilage zwischen Herta Herzog und Max Horkheimer, 1949; 23 Briefe zwischen dem Hessischen Staatsministerium für Kultus und Unterricht und Max Horkheimer, 1948-1949 siehe auch Hessischer Minister für Erziehung und Volkdsbildung; 2 Briefe von Eduard Heumann an Max Horkheimer, 1948-1949; 1 Brief und Beilage von George J. Hexter an A. Lourie; 35 Briefe zwischen Käte von Hirsch und Max Horkheimer, 1941-1948;

Ms. lat. qu. 74 - Moralia in Job XXXI 45

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Ms. lat. oct. 74 - Physiologia Aristotelis Stagiritae

Vorbesitzer: Peter Schick

{[N.N.], Szenenfoto, Doppelbildnis, in: Johann Wolfgang von Goethe: Stella, Darmstadt: Staatstheater, 1973/74, Inszenierung: Luc Bondy, Bühnenbild: Erich Wonder

Signatur des Originals: S 36/F11347

{[N.N.], Szenenfoto, Gruppenbildnis, in: Johann Wolfgang von Goethe: Stella, Darmstadt: Staatstheater, 1973/74, Inszenierung: Luc Bondy, Bühnenbild: Erich Wonder

Signatur des Originals: S 36/F11348