Classification criteria and commercial profile re-definition of the Family Farm Agriculture in Chile, Maule region

In Chile, small-scale farmers are classified according to old approaches from 1993 that do not include changes occurred in the last two decades. Maule is the region with most rural population in Chile which represents a significant stratum for development, innovation and competitiveness. This study explores a new approach of small-scale farmers -associated with Family Farm Agriculture (AFC) - classification in Chile and it describes a commercial profile or AFC-1 for famers of the Maule Region. A Cluster analysis to determine AFC-1 farmers is used. The analysis includes four association variables: Total Assets, Farm Income, Production Costs and Management Indicators. The results suggest that 16.4% of the farmers have a commercial profile and they could stay out support provided by the National Institute for Agricultural Development (INDAP). This group of farmers would not belong to AFC in short terms. This fact could bring restriction to AFC-1 farmers such as lack of credit access, less investment incentives and technical assistance. Thus, it would expect low process of technology adoption and welfare improvement. New agrarian policies must be warranted to support this important group of famers with a commercial profile.

Essential elements of postabortion care: origins, evolution and future directions

In this comment, we chronicle the development and expansion of a postabortion care model designed to promote interventions that address abortion-related public health concerns even when abortion laws and policies are restrictive. We review years of program experience with the original model, which led to the development of an expanded and updated model, Essential Elements of Postabortion Care (PAC). Implementing the model challenges global public health leaders, donors, technical assistance agencies and ministries of health to work with communities to ensure that all women who want to prevent or space pregnancies can obtain contraceptive services; that all women have access to services to manage complications from abortion, whether induced or spontaneous; and that all women receiving treatment also receive counseling and the reproductive and other health services they need at the treatment visit, as well as follow-up care and contraceptive resupply

Territorio y extensión universitaria. Una experiencia de organización social en el Parque Pereyra Iraola

El trabajo que aquí se presenta recupera la experiencia de organización social y extensión que universitarios, militantes y técnicos rurales viene desarrollando en el Parque Pereyra Iraola desde el año 2001 junto a un grupo de 40 familias, como una estrategia de respuesta a la crisis. Se propone entender el proceso de transformación en la toma de posición territorial de los quinteros como un sistema de relaciones complejo entre la posición social de los productores, la irregularidad en la forma de tenencia de la tierra, la resistencia espontánea al desalojo, el posicionamiento de los extensionistas rurales que brindan asistencia técnica y la estrategia de conversión a la producción sin agrotóxicos.

Territorio y extensión universitaria. Una experiencia de organización social en el Parque Pereyra Iraola

El trabajo que aquí se presenta recupera la experiencia de organización social y extensión que universitarios, militantes y técnicos rurales viene desarrollando en el Parque Pereyra Iraola desde el año 2001 junto a un grupo de 40 familias, como una estrategia de respuesta a la crisis. Se propone entender el proceso de transformación en la toma de posición territorial de los quinteros como un sistema de relaciones complejo entre la posición social de los productores, la irregularidad en la forma de tenencia de la tierra, la resistencia espontánea al desalojo, el posicionamiento de los extensionistas rurales que brindan asistencia técnica y la estrategia de conversión a la producción sin agrotóxicos.

Territorio y extensión universitaria. Una experiencia de organización social en el Parque Pereyra Iraola

El trabajo que aquí se presenta recupera la experiencia de organización social y extensión que universitarios, militantes y técnicos rurales viene desarrollando en el Parque Pereyra Iraola desde el año 2001 junto a un grupo de 40 familias, como una estrategia de respuesta a la crisis. Se propone entender el proceso de transformación en la toma de posición territorial de los quinteros como un sistema de relaciones complejo entre la posición social de los productores, la irregularidad en la forma de tenencia de la tierra, la resistencia espontánea al desalojo, el posicionamiento de los extensionistas rurales que brindan asistencia técnica y la estrategia de conversión a la producción sin agrotóxicos.

Microinformática en entornos profesionales : instalación, configuración, mantenimiento y reparación

Los sistemas microinformáticos se componen principalmente de hardware y software, con el paso del tiempo el hardware se degrada, se deteriora y en ocasiones se avería. El software evoluciona, requiere un mantenimiento, de actualización y en ocasiones falla teniendo que ser reparado o reinstalado. A nivel hardware se analizan los principales componentes que integran y que son comunes en gran parte estos sistemas, tanto en equipos de sobre mesa como portátiles, independientes del sistema operativo, además de los principales periféricos, también se analizan y recomiendan algunas herramientas necesarias para realizar el montaje, mantenimiento y reparación de estos equipos. Los principales componentes hardware internos son la placa base, memoria RAM, procesador, disco duro, carcasa, fuente de alimentación y tarjeta gráfica. Los periféricos más destacados son el monitor, teclado, ratón, impresora y escáner. Se ha incluido un apartado donde se detallan los distintos tipos de BIOS y los principales parámetros de configuración. Para todos estos componentes, tanto internos como periféricos, se ha realizado un análisis de las características que ofrecen y los detalles en los que se debe prestar especial atención en el momento de seleccionar uno frente a otro. En los casos que existen diferentes tecnologías se ha hecho una comparativa entre ambas, destacando las ventajas y los inconvenientes de unas frente a otras para que sea el usuario final quien decida cual se ajusta mejor a sus necesidades en función de las prestaciones y el coste. Un ejemplo son las impresoras de inyección de tinta frente a las laser o los discos duros mecánicos en comparación con y los discos de estado sólido (SSD). Todos estos componentes están relacionados, interconectados y dependen unos de otros, se ha dedicado un capítulo exclusivamente para estudiar cómo se ensamblan estos componentes, resaltando los principales fallos que se suelen cometer o producir y se han indicado unas serie tareas de mantenimiento preventivo que se pueden realizar para prolongar la vida útil del equipo y evitar averías por mal uso. Los mantenimientos se pueden clasificar como predictivo, perfectivo, adaptativo, preventivo y correctivo. Se ha puesto el foco principalmente en dos tipos de mantenimiento, el preventivo descrito anteriormente y en el correctivo, tanto software como hardware. El mantenimiento correctivo está enfocado al análisis, localización, diagnóstico y reparación de fallos y averías hardware y software. Se describen los principales fallos que se producen en cada componente, cómo se manifiestan o qué síntomas presentan para poder realizar pruebas específicas que diagnostiquen y acoten el fallo. En los casos que es posible la reparación se detallan las instrucciones a seguir, en otro caso se recomienda la sustitución de la pieza o componente. Se ha incluido un apartado dedicado a la virtualización, una tecnología en auge que resulta muy útil para realizar pruebas de software, reduciendo tiempos y costes en las pruebas. Otro aspecto interesante de la virtualización es que se utiliza para montar diferentes servidores virtuales sobre un único servidor físico, lo cual representa un importante ahorro en hardware y costes de mantenimiento, como por ejemplo el consumo eléctrico. A nivel software se realiza un estudio detallado de los principales problemas de seguridad y vulnerabilidades a los que está expuesto un sistema microinformático enumerando y describiendo el comportamiento de los distintos tipos de elementos maliciosos que pueden infectar un equipo, las precauciones que se deben tomar para minimizar los riesgos y las utilidades que se pueden ejecutar para prevenir o limpiar un equipo en caso de infección. Los mantenimientos y asistencias técnicas, en especial las de tipo software, no siempre precisan de la atención presencial de un técnico cualificado, por ello se ha dedicado un capítulo a las herramientas de asistencia remota que se pueden utilizar en este ámbito. Se describen algunas de las más populares y utilizadas en el mercado, su funcionamiento, características y requerimientos. De esta forma el usuario puede ser atendido de una forma rápida, minimizando los tiempos de respuesta y reduciendo los costes. ABSTRACT Microcomputer systems are basically made up of pieces of hardware and software, as time pass, there’s a degradation of the hardware pieces and sometimes failures of them. The software evolves, new versions appears and requires maintenance, upgrades and sometimes also fails having to be repaired or reinstalled. The most important hardware components in a microcomputer system are analyzed in this document for a laptop or a desktop, with independency of the operating system they run. In addition to this, the main peripherals and devices are also analyzed and a recommendation about the most proper tools necessary for maintenance and repair this kind of equipment is given as well. The main internal hardware components are: motherboard, RAM memory, microprocessor, hard drive, housing box, power supply and graphics card. The most important peripherals are: monitor, keyboard, mouse, printer and scanner. A section has been also included where different types of BIOS and main settings are listed with the basic setup parameters in each case. For all these internal components and peripherals, an analysis of their features has been done. Also an indication of the details in which special attention must be payed when choosing more than one at the same time is given. In those cases where different technologies are available, a comparison among them has been done, highlighting the advantages and disadvantages of selecting one or another to guide the end user to decide which one best fits his needs in terms of performance and costs. As an example, the inkjet vs the laser printers technologies has been faced, or also the mechanical hard disks vs the new solid state drives (SSD). All these components are interconnected and are dependent one to each other, a special chapter has been included in order to study how they must be assembled, emphasizing the most often mistakes and faults that can appear during that process, indicating different tasks that can be done as preventive maintenance to enlarge the life of the equipment and to prevent damage because of a wrong use. The different maintenances can be classified as: predictive, perfective, adaptive, preventive and corrective. The main focus is on the preventive maintains, described above, and in the corrective one, in software and hardware. Corrective maintenance is focused on the analysis, localization, diagnosis and repair of hardware and software failures and breakdowns. The most typical failures that can occur are described, also how they can be detected or the specific symptoms of each one in order to apply different technics or specific tests to diagnose and delimit the failure. In those cases where the reparation is possible, instructions to do so are given, otherwise, the replacement of the component is recommended. A complete section about virtualization has also been included. Virtualization is a state of the art technology that is very useful especially for testing software purposes, reducing time and costs during the tests. Another interesting aspect of virtualization is the possibility to have different virtual servers on a single physical server, which represents a significant savings in hardware inversion and maintenance costs, such as electricity consumption. In the software area, a detailed study has been done about security problems and vulnerabilities a microcomputer system is exposed, listing and describing the behavior of different types of malicious elements that can infect a computer, the precautions to be taken to minimize the risks and the tools that can be used to prevent or clean a computer system in case of infection. The software maintenance and technical assistance not always requires the physical presence of a qualified technician to solve the possible problems, that’s why a complete chapter about the remote support tools that can be used to do so has been also included. Some of the most popular ones used in the market are described with their characteristics and requirements. Using this kind of technology, final users can be served quickly, minimizing response times and reducing costs.

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

We thank Karim Gharbi and Urmi Trivedi for their assistance with RNA sequencing, carried out in the GenePool genomics facility (University of Edinburgh). We also thank Susan Fairley and Eduardo De Paiva Alves (Centre for Genome Enabled Biology and Medicine, University of Aberdeen) for help with the initial bioinformatics analysis. We thank Aaron Mitchell for kindly providing the ALS3 mutant, Julian Naglik for the gift of TR146 cells, and Jon Richardson for technical assistance. We thank the Genomics and Bioinformatics core of the Faculty of Health Sciences for Next Generation Sequencing and Bioinformatics support, the Information and Communication Technology Office at the University of Macau for providing access to a High Performance Computer and Jacky Chan and William Pang for their expert support on the High Performance Computer. Finally, we thank Amanda Veri for generating CaLC2928. M.D.L. is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), R.A.F. by a Wellcome Trust-Massachusetts Institute of Technology (MIT) Postdoctoral Fellowship, L.E.C. by a Canada Research Chair in Microbial Genomics and Infectious Disease and by Canadian Institutes of Health Research Grants MOP-119520 and MOP-86452, A.J. P.B. was supported by the UK Biotechnology and Biological Sciences Research Council (BB/F00513X/1) and by the European Research Council (ERC-2009-AdG-249793-STRIFE), KHW is supported by the Science and Technology Development Fund of Macau S.A.R (FDCT) (085/2014/A2) and the Research and Development Administrative Office of the University of Macau (SRG2014-00003-FHS) and R.T.W. by the Burroughs Wellcome fund and NIH R15AO094406. Data availability RNA-sequencing data sets are available at ArrayExpress (www.ebi.ac.uk) under accession code E-MTAB-4075. ChIP-seq data sets are available at the NCBI SRA database (http://www.ncbi.nlm.nih.gov) under accession code SRP071687. The authors declare that all other data supporting the findings of this study are available within the article and its supplementary information files, or from the corresponding author upon request.

Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice

Acknowledgements This project was also supported by Marie Curie International Reintegration Grant 249156 (A. Lionikas) and the grants VP1-3.1-SMM-01-V-02-003 (A. Kilikevicius) and MIP-067/2012 (T. Venckunas) from the Research Council of Lithuania as well as the grant from the Ministry of Higher Education of Saudi Arabia (Y. Alhind). We wish also to thank Mrs Indre Libnickiene for her excellent technical assistance provided during the project

Orchestration of gene expression across the seasons : Hypothalamic gene expression in natural photoperiod throughout the year in the Siberian hamster

Funding for work in the laboratory of PB was supported by Scottish Government Rural and Environment Science and Analytical Services Division, BBSRC (grant BB/M001504/1), British Society for Neuroendocrinology (research visit grant to IP). Work in the laboratory of SS was supported by a grant from the DFG (Ste 331/8-1). We thank Siegried Hilken, Marianne Brüning, Dr. Esther Lipokatic-Takacs and Dr. Frank Scherbarth at UVMH for technical assistance. We thank Graham Horgan of Bioinformatics, Statistics Scotland for assistance with some of statistical tests.

Social determinants of sexual satisfaction in Spain considered from the gender perspective

Aims: To describe gender- and social class-related inequalities in sexual satisfaction and analyze their relationship with self-perceived health status. Methods: This population-based, cross-sectional study included 7384 sexually active people aged 16 years and over residing in Spain in 2009 (3951 men and 3433 women). The explanatory variables were gender, age, social class, share in performing domestic tasks, spend time looking after oneself, collaborate economically in supporting the family, caring for children, self-perceived health status, and the desire to increase or decrease frequency of having sexual relations. Bivariate and multivariate logistic regression models were fitted. Results: Among women, sexual satisfaction declines progressively after age 45. Sexual satisfaction is 1.7 times higher among women who look after themselves and who feel good compared with those who do not. The odds of wanting to increase sex is 3.3 times higher for women who are satisfied compared with women who desire a lower frequency of sexual intercourses; and good perceived health was associated with sexual satisfaction. In satisfied men, the corresponding odds is 1.9 times that of men desiring to reduce their frequency of sex. Conclusions: Gender and social class inequalities are found in sexual satisfaction. This is associated with perceived health status, adding evidence in support of the World Health Organization definition of sexual health.

Restarting Ukraine’s Economy. CEPS Commentary, 8 April 2014

Notes Regardless of whether Ukraine is ‘lost’, or who lost it, Daniel Gros finds in this new Commentary that the country can still offer an attractive future for all of its citizens if unavoidable economic reforms can be made compatible with regional cohesion. He urges the EU to play an essential role in the process by opening its market and providing funding and technical assistance in crucial areas.

Review of the Economic Development in the Western Balkan States. OSW STUDIES No. 19, 2005-08-10

Foreword. Ten years after the end of the armed conflict, the Western Balkans1 are still being considered as the “land of the unsuccessful policies”. Enormous financial and technical assistance transferred by the International Community has not managed to meet the goals of integrating the region within itself as well as within the European markets. Explanation for this can be found in the consequences of the war and the remnants of the socialist state. The complexity of current institutional/ political arrangements combined with the limited willingness of the regional actors to introduce and implement much of the needed reforms have additionally contributed to the current state of affairs. The economy and politics in the region intertwine to an extent as probably in none of the other post-communist states. Therefore, the paper presents the recent economic performance of the Western Balkan countries in the light of their limited institutional development and lack of efficient regional cooperation. The paper discusses the importance of foreign direct investments’ inflow for the economic growth of the “latecomer” states and presents major drawbacks which limit the influx of the foreign capital to the region. It presents private sector activity and regional cooperation programmes. It discusses the role of the International Community with the main focus on the activities of the European Union. The EU is examined not only as the main aid donor but more importantly as a foreign trade partner. Furthermore, it analyses the impact of the presence of the International Community and their strategies towards the region with the special attention to the EU. Finally, it presents recommendations for the improvement of the economic performance in light of the enhanced political cooperation between the EU and the region.

Rebalancing the EU-Russia-Ukraine gas relationship. Bruegel Policy Contribution ISSUE 2014/15, DECEMBER 2014

The October 2014 agreement on gas supplies between Russia, Ukraine and the European Union did not resolve the Ukraine-Russia conflict over gas. The differences between parties in terms of objectives, growing mistrust and legacy issues make it unlikely that a long-term stable arrangement will be achieved without further escalation. Without EU pressure and support, Ukraine is likely to enter a new unfavourable gas arrangement with Russia, which could have repercussions beyond the energy sector. Key highlights: To reduce prices and increase the security of imports, the EU as a bloc should redefine its gas relationship with Russia and Ukraine and overcome the diverging interests of EU member states on second-order issues. Implementation of a joint strategy rests on enforcement of EU competition and gas market rules, a strengthened role for the Energy Community and the establishment of a market-based instrument for supply security. For Ukraine, the EU should serve as an anchor for comprehensive gas sector reform. Contingent on Ukraine’s reform efforts, EU financial and technical assistance, the enabling of reverse flows from the EU to Ukraine and pressure on Gazprom, should eventually enable Ukraine to obtain a sustainable gas-supply contract with Russia. This should make a sustainable and mutually beneficial Russia-Ukraine-EU gas relationship possible. However, during the transition, the EU should be prepared for possible frictions.

The harsh reality of Ukraine's fiscal arithmetic. Bruegel Policy Contribution ISSUE 2015/07, June 2015

Ukraine is struggling with both external aggression and the dramatically poor shape of its economy. The pace of political and institutional change has so far been too slow to prevent the deepening of the fiscal and balance-of-payments crises, while business confidence continues to be undermined. • Unfortunately, the 2015 International Monetary Fund Extended Fund Facility programme repeats many weaknesses of the 2014 IMF Stand-by Arrangement: slow pace of fiscal adjustment especially in the two key areas of energy prices and pension entitlements, lack of a comprehensive structural and institutional reform vision, and insufficient external financing to close the expected balance-of-payments gap and allow Ukraine to return to debt sustainability in the long term. • The reform process in Ukraine must be accelerated and better managed. A frontloaded fiscal adjustment is necessary to stabilise public finances and the balance-of-payments, and to bring inflation down. The international community, especially the European Union, should offer sufficient financial aid backed by strong conditionality, technical assistance and support to Ukraine’s independence and territorial integrity.

Countries under Adjustment Programmes: What role for the ECB? CEPS Special Report No. 124, December 2015

Providing ‘technical assistance/advice’ on programmes for countries under financial stress is well within the mandate of the European Central Bank (ECB). Being fully part of the Troika, however, is a different role. Formally the ECB does not participate in the ‘decision-making’ on programmes (decisions are taken by the Finance Ministers – and the IMF). However, the ECB is part of the ‘decision-shaping’ process. These two roles have often been confused. The ECB should interpret its formal role in future ESM (European Stability Mechanism) programmes as narrowly as possible. Providing advice but avoid taking part in the operational work of programme surveillance. The ECB should de facto leave the Troika. At any rate, future incidents like the Italian or Spanish letters will be superseded by the OMTs (outright monetary transactions) and an Irish-type situation would be shaped by the legal framework of the Bank Recovery and Resolution Directive (BRRD) and the potential funding from the Single Resolution Fund (SRF). An additional issue for the ECB is internal coherence: Its six-member Executive Board manages the participation in the Troika, monetary policy is decided by the Governing Council and banking supervision is under the Supervisory Board, separated in principle by Chinese walls from the (rest of the) ECB.