941 resultados para Synthetic and natural cannabinoids
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"Publication no. 97-79."
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"Publication no. 97-111."
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Distributed to some depository libraries in microfiche.
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"Coeur D'Alene, Idaho, August 16, 1983; Lewiston, Idaho, August 17, 1983"--Pt. 2.
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"June 23, 1988"--pt. 2.
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"February 28, 1989"--Pt. 1.
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Shipping list no.: 90-134-P (pt. 1).
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Shipping list no.: 90-394-P.
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Dendritic cells (DCs) regulate various aspects of innate immunity, including natural killer (NK) cell function. Here we define the mechanisms involved in DC - NK cell interactions during viral infection. NK cells were efficiently activated by murine cytomegalovirus ( MCMV) - infected CD11b(+) DCs. NK cell cytotoxicity required interferon-alpha and interactions between the NKG2D activating receptor and NKG2D ligand, whereas the production of interferon-gamma by NK cells relied mainly on DC-derived interleukin 18. Although Toll-like receptor 9 contributes to antiviral immunity, we found that signaling pathways independent of Toll-like receptor 9 were important in generating immune responses to MCMV, including the production of interferon-alpha and the induction of NK cell cytotoxicity. Notably, adoptive transfer of MCMV-activated CD11b(+) DCs resulted in improved control of MCMV infection, indicating that these cells participate in controlling viral replication in vivo.