Determinantes genéticos, bioquímicos e clínicos na resposta ao uso de hidroxiureia na doença falciforme

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Variação, herdabilidade e ganhos genéticos em progênies de Eucalyptus tereticornis aos 25 anos de idade em Batatais-SP

The wood of Eucalyptus tereticornis is intensively used for timber, structures, buildings, poles, posts and coal. The aim of this study was to estimate genetic parameters and genetic and phenotypic correlations in growth and stem form traits of 52 open-pollinated progenies of E. tereticornis sampled from three Australian populations (20 progenies from Helenvale, 19 from Ravenshoe and 13 from Mt. Garnet). The progenies were compared with three commercial control also from Australian. The experimental design used was the compact family block, with the effect of provenance allocated in the plots and progenies within provenances in the subplots. Ten repetitions of the 52 treatments, sub-plots with six plants and the spacing of 3 x 2 m was used. At 25 years of age it was measured the diameter at breast height (DBH), total height, true volume and the stem form. We found genetic variation amon and within the three provenances and the possibility of obtaining high gains from mass selection and individual among and within progenies. The provenance Helenvale showed the best development for DBH, height and volume. The traits DBH, height and volume showed high genetic correlations (> 0.9), indicating the possibility to use the indirect selection. The coefficient of heritability on a progeny mean for the traits DBH and height was median, being 0.31 and 0.30, respectively. The expected genetic gain with the selection were estimated at 12.4% for DBH and 8.5 % for plant height. These results will subsidize the transformation of the provenance and progeny test in a seedling seed orchard and a clonal seed orchard.

Estimativas de parâmetros genéticos para características de habilidade materna e reprodutivas em fêmeas da raça Santa Inês

Pós-graduação em Ciência e Tecnologia Animal - FEIS

Perfil de mutações de resistência e polimorfismos genéticos em variantes do vírus da hepatite B circulantes na região de Botucatu

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Incorporação do carbono13 nos tecidos muscular e hepático de frangos de corte de diferentes grupos genéticos criados em estresse cíclico de calor

Pós-graduação em Zootecnia - FCAV

Estimativas de parâmetros genéticos em linhagens avançadas de soja

Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV

Análise de pedigree e estimativas de parâmetros genéticos para características de importância econômica em bovinos Tabapuã

Pós-graduação em Genética e Melhoramento Animal - FCAV

Estimativas de parâmetros genéticos para seleção precoce de clones de Eucalyptus para região com ocorrência de geadas

Further to increase the wood yield, is important goal of forest tree breeding the adaptation of clones through diverse environment, especially for soil and climate. Perennial tree species such as eucalypts, have a long life cycle and the frosts can occur and to be their limiting source of cultivation. The aim of the study was to determine the genetic variability and the genetic correlations between selection ages of clones cultivated in the municipality of Palma So la, SC, Brazil, where frosts are common in the winter. A clonal trial was set up in 2008 in Palma So la, by statistical design of randomized complete blocks considering 29 clones, six replications, six plants per plot, and 3.0m x 3.0 m spacing. The silvicultural characters of total plant height, diameter of breast height (dbh), and wood volume were evaluated through 24, 36, 48, and 60 months old. The deviance analysis and estimates of genetic parameters were based on the REML / BLUP genetic statistical procedure. Significant differences were observed for all traits in the deviance analysis. High correlations and statistically significant between characters were observed, indicating that the early selection will provide significant gains. Part of the clones USP/IPEF 64, USP/IPEF 78, USP/IPEF 52, USP/IPEF 68, and USP/IPEF 74) are potential to be used into the breeding programs and in commercial stands into the studied frost regions.

Desenvolvimento de solução para o problema de alocação de navios em berços de terminais portuários: aplicação de algoritmos genéticos e otimização por nuvens de partículas

This work proposes two optimization algorithms for the solution of the Berth Allocation Problem (PAB). Due to the economic development of the country, it became necessary for the improvement of means of transport, which mainly shipping. For this, you need a better system management port, you will receive a lot of ships carrying cargo. In this work the PAB is approached so that the goals are to reduce costs and time handling in ports. For this, we applied two computational techniques, genetic algorithms and optimization for cloud particles, to obtain the best results for this problem. The results obtained with each type of algorithm are compared to conclude which method is more efficient for the port system

Uso de algoritmos genéticos na otimização do sistema de coleta do palhiço de cana-de-açúcar

The Brazilian government has convinced the world that ethanol deriving from sugar cane is a promissory means of sustainable fuel for vehicles. There is a great growth of ex vehicles , i.e, run both by ethanol and gasoline, due to competent automotive industries and e cient alcohol production technology. In 2009 and 2010 the ethanol production was 25.7 billion liters and 53.8% of sugar cane production was destined to alcohol production. Nevertheless, the sugar production also derived from sugar cane should increase in 2011. Brazil produced 33 million tons of sugar in the last harvest. With sugar cane on the rise production is arising new environmental problems. The harvest using mechanized cut besides improving the logistic transportation system leaves the generating residue in the eld. This residue is a mixture of straw, leavings and scrap of sugar cane named sugar cane crop residue and corresponds to 30% of biomass and can be burned and produce electricity by cogeneration. But the transport the sugar cane crop from the eld is expensive due costs involved in the transport system. This work aims to propose a formulation for the bales collecting problem from sugar cane eld to mill that minimize the costs involved in the transport system. The computational tests use the C++ language and an algorithm based on genetic algorithms techniques

Amplificação, clonagem e sequenciamento de promotores de café (Coffea arabica cv Mundo Novo) específicos de fruto e ubíquos

The Coffee Genome Project made available to the scientific community relevant information that made practical the identification and cloning of important genes, as well as the identification of the major sequences involved on their regulation. The aim of the present study was to amplify, clone and sequence coffee promoters with specific expression patterns. For that, coffee ESTs which known expression profiles were employed. First, the promoter regions of coffee genes showing, respectively, fruitspecific and ubiquitous expression were amplified using the Genome Walking strategy. Amplified sequences were then inserted in the pGEM-Teasy vector (Promega) and sequenced. Once completed the sequencing, an expression cassette was constructed using the binary vector pCAMBIA-1381z (Cambia). These expression cassettes were cloned into Agrobacterium tumefaciens, and transgenic tobacco plants were generated aiming the functional characterization of these promoters

Efeitos genéticos tardios de terapias para linfomas

O tratamento dos Linfomas de Hodgkin e Não - Hodgkin é baseado, atualmente, na combinação de drogas antineoplásicas, associadas ou não à radioterapia. Embora as taxas de cura sejam elevadas, sabe-se que tais terapias podem induzir mutações gênicas e cromossômicas que, mais tarde, podem ser responsáveis pela iniciação de novos processos carcinogênicos ou de doenças degenerativas relacionadas a danos genéticos. Sendo assim, o presente estudo teve por objetivo avaliar o efeito toxicogenético tardio (sobre os níveis de danos no DNA) das terapias antineoplásicas para linfomas. Para isso, foram incluídos no estudo 10 pacientes recém diagnosticados com linfoma (Grupo 1- Pré-terapia), 10 pacientes com história de linfoma e que finalizaram o tratamento antineoplásico há no mínimo dois anos (Grupo 2- Pós-terapia) e 10 indivíduos saudáveis (Grupo 3- Controles). Os linfócitos de sangue periférico foram utilizados para se avaliar os níveis de danos no DNA pelo teste do cometa. Além disso, foi avaliada a eficiência do sistema de reparo do DNA frente às lesões induzidas in vitro pelo peróxido de hidrogênio (H2O2). Os dados mostraram que não houve diferença estatisticamente significativa nos níveis de danos no DNA entre os três grupos. No entanto, foram observadas diferenças estatisticamente significativas no reparo das lesões induzidas pelo (H2O2), com o grupo controle apresentado maior indução de danos em comparação com aos demais grupos (p <0,05). Concluindo, os resultados não evidenciaram efeitos toxicogenéticos tardios decorrentes da exposição às terapias antineoplásicas para linfomas

Variabilidade entre materiais genéticos de eucalyptus spp quanto à distribuição de raízes finas em latossolos profundos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Parâmetros genéticos para características de desempenho e reprodutivas de aves poedeiras por inferência bayesiana

Pós-graduação em Genética e Melhoramento Animal - FCAV

Parâmetros genéticos para integridade óssea do fêmur e estudo da associação dos genes runx2 e tnfs11 em frangos de corte

Pós-graduação em Genética e Melhoramento Animal - FCAV