Ms. lat. oct. 231 - Alchimistische Sammelhandschrift

Vorbesitzer: Heinrich Kellner; Freiherren von Holzhausen

Na 1 Nachlass Max Horkheimer, 558 - Korrespondenzen mit Leo Löwenthal (p. VI 24, 231-449)

139 Briefe zwischen Max Horkheimer und Leo Löwenthal; 5 Briefe zwischen Charles Y. Glock und Max Horkheimer; 2 Briefe von Leo Löwenthal an Frederick Pollock, 1951/1952; 1 Brief von Leo Löwenthal an Theodor W. Adorno, 10.06.1952; 2 Briefe zwischen Max Horkheimer und Max Rheinstein, 1953; 2 Briefe von Max Horkheimer an Herbert W. Schneider, 16.07.1953;

Na 1 Nachlass Max Horkheimer, 567 - Korrespondenzen u.a. mit Paul Massing (p. VI 28, 1-231)

58 Briefe zwischen Paul Massing und Max Horkheimer, 1940 - 1949; 15 Briefe zwischen Alice H. Maier und Paul Massing, 1950 - 1964; 4 Briefe zwischen Paul Massing und Fred M. Stein, 1943; 1 Brief an Marc Vosk von Paul Massing, 25.10.1949; 2 Briefe zwischen Paul Massing und James T. Shotwell, Juni 1947; 1 Brief von Max Horkheimer an das Chancellor Hotel (San Francisco), 08.01.1947; 2 Brief von dem American Friends Service Committee (Philadelphia) an Max Horkheimer, 1946/1947; 1 Brief an Leo Löwenthal von Paul Massing, 09.08.1949; 1 Brief an Paul Massing von Samuel J. Kramer, 15.01.1945; 44 Briefe zwischen Max Horkheimer und Heinz Maus, 1939 - 1950; 3 Briefe von Heinz Maus an Leo Löwenthal, 1948- 1949; 1 Brief von Margot von Mendelssohn an Max Horkheimer, 29.03.1948;

The effect of protein tyrosine phosphatase SHP1 on tumorigenicity of the MDA -MB231 breast cancer cells

SHP1 is a cytosolic protein tyrosine phosphatase that contains two SH2 domains. It is highly expressed in hematopoietic cells and expressed in normal epithelium at lower levels. While SHP1 in hematopoietic cells is thought to be a negative regulator of cellular signaling by associating with and dephosphorylating various receptors and their downstream effectors after they become activated, its precise function in epithelium remains to be understood. The potential involvement of SHP1 in human tumorigenesis has been hypothesized from the findings that SHP1 can interact with, dephosphorylate, and regulate the activity of several protein tyrosine kinases (PTKs) implicated in human cancer. These PTKs include epidermal growth factor receptor (EGFR) and Src. Such speculation is also supported by the report that SHP1 is overexpressed in human ovarian cancers. ^ Here we report, for the first time, that the levels of SHP1 expression and activity are altered in human breast cancer cells in comparison with normal breast epithelium. In particular, SHP1 expression is nearly lost in the breast cancer cell lines MDA-MB231 and MDA-MB435. After the re-introduction of SHP1 both in wild type (wt) and enzymatically inactive (dn) forms, into the MDA-MB231 cells, we observed no changes in cellular proliferation. However, the overexpression of wt SHP1 led to increased anchorage-independent growth in the MDA-MB231 cells. SHP1 phosphatase activity is essential for such an increase since the overexpression of dn SHP1 had no effect. Enhanced turnorigenicity in nude mice was also observed in the MDA-MB231 cells overexpressing wt SHP1, but not dn SHP1, suggesting the crucial function of SHP1 enzymatic activity in this process. Our observations in this study indicate that SHP1 promotes tumorigenesis by a mechanism or mechanisms apart from enchancing angiogenesis. In addition, we have found no evidence that the overexpression of SHP1 could affect metastatic potential in the MDA-MB231 cells. ^ In the MDA-MB231 cells stably transfected with either wt or dn SHP1 the peak level of EGFR tyrosine phosphorylation induced by EGF, as well as the sensitivity to EGF stimulation, was not altered. However, the overexpression of wt SHP1 led to a slight increase in the kinetics of EGFR dephosphorylation, whereas the overexpression of dn SHP1 led to slightly delayed kinetics of EGFR dephosphorylation. The overexpression of either the wt or dn SHP1 did not lead to any significant increase in Src kinase activity. ^ In NIH3T3 cells, the transient overexpression of SHP1 led to no significant changes in MAP kinase (ERK2) activation by EGF or Akt activation by PDGF. In 3T3H4 cells, the transient overexpression of SHP1 led to no significant changes in MAP kinase (ERK2) activation by heregulin. The transient overexpression of wt SHP1 in the MDA-MB231 cells caused an apparent increase, ranging from 10% to 20%, in the G0/G1 population of the cells with a corresponding decrease in the S phase population. ^ In order to understand the mechanisms by which SHP1 exerts its positive effect on the tumorigenic potential of the MDA-MB231 cells, we employed two-dimensional electrophoresis in an attempt to identify cellular protein(s) with significantly altered tyrosine phosphorylation level upon wt SHP1 overexpression. The overexpression of wt SHP1 but not dn SHP1, leads increased tyrosine phosphorylation of a protein with a molecular weight of approximately 40 kDa and a pI between 5.9 to 6.6. ^

Mean dynamic topography and oceanographic parameters estimated from an inverse model and satellite geodesy, with link to model result in one single NetCDF file (392 MB), including the inverse data error covariance

Geostrophic surface velocities can be derived from the gradients of the mean dynamic topography-the difference between the mean sea surface and the geoid. Therefore, independently observed mean dynamic topography data are valuable input parameters and constraints for ocean circulation models. For a successful fit to observational dynamic topography data, not only the mean dynamic topography on the particular ocean model grid is required, but also information about its inverse covariance matrix. The calculation of the mean dynamic topography from satellite-based gravity field models and altimetric sea surface height measurements, however, is not straightforward. For this purpose, we previously developed an integrated approach to combining these two different observation groups in a consistent way without using the common filter approaches (Becker et al. in J Geodyn 59(60):99-110, 2012, doi:10.1016/j.jog.2011.07.0069; Becker in Konsistente Kombination von Schwerefeld, Altimetrie und hydrographischen Daten zur Modellierung der dynamischen Ozeantopographie, 2012, http://nbn-resolving.de/nbn:de:hbz:5n-29199). Within this combination method, the full spectral range of the observations is considered. Further, it allows the direct determination of the normal equations (i.e., the inverse of the error covariance matrix) of the mean dynamic topography on arbitrary grids, which is one of the requirements for ocean data assimilation. In this paper, we report progress through selection and improved processing of altimetric data sets. We focus on the preprocessing steps of along-track altimetry data from Jason-1 and Envisat to obtain a mean sea surface profile. During this procedure, a rigorous variance propagation is accomplished, so that, for the first time, the full covariance matrix of the mean sea surface is available. The combination of the mean profile and a combined GRACE/GOCE gravity field model yields a mean dynamic topography model for the North Atlantic Ocean that is characterized by a defined set of assumptions. We show that including the geodetically derived mean dynamic topography with the full error structure in a 3D stationary inverse ocean model improves modeled oceanographic features over previous estimates.

Jaim Etcheverry, Guillermo. La tragedia educativa. Buenos Aires, Fondo de Cultura Económica, 1999, 231 p.

Fil: Mastrangelo, Fabiana.

Karte eines Teiles der Mittelinsel von Nordland ("Insel der Oktober-Revolution") (Ergänzungsheft 216, Tafel 1, png-format 37 MB)

Unterlage für diese Karte bilden in der Hauptsache Aufnahmen, die mit der Zweifach-Reihenbildkammer am 28. Juli 1931 in der Zeit von 6 Uhr 30 Min. MGZ. bis 9 Uhr 45 Min. aufgenommen worden sind. Außerdem sechs Aufnahmen mit der Handmeßkammer. Zur Ergänzung konnten 14 Aufnahmen der Panoramakammer herangezogen werden. Die Karte umfaßt einen nördlichen Teil vom Sund der Roten Armee bis zum Beginn des Matussewitsch-Sees mit einem Teil der Nordostküste und einen südlichen Teil mit Schokalski-Sund und dessen östlicher Begrenzung durch die Südinsel. Zwischen beiden Teilen der Karte klafft eine Lücke, hervorgerufen durch eine für die photographische Aufnahme undurchdringliche Nebeldecke.

Karczmarczyk, Pedro. Gadamer: aplicación y comprensión. La Plata, Editorial de la Universidad Nacional de La Plata, 2007, 231 pp.

Fil: Oviedo, Gerardo.