The etchings of Canaletto (Antonio Canale, 1697-1768) : "views, some taken from actual spots, others fanciful" /

Mode of access: Internet.

Merkwurdige... Nebst angehängtem Reichs-Hof-Raths-Teutsch u. Latein. Anschlagsprotocoll pro a. 1726.

Mode of access: Internet.

Christian Friedrich Pfeffels politische Tatigkeit in Regensburg und Munchen 1758-1768.

Thesis (doctoral)--Ruprecht-Karls-Universitat zu Heidelberg.

A publisher and his friends; memoir and correspondence of John Murray, with an account of the origin and progress of the house, 1768-1843,

Mode of access: Internet.

Mémoires de Barthélemy, 1768-1819;

Mode of access: Internet.

Œuvres de P. Corneille, avec le commentaire de Voltaire sur les pièces de théâtre, et des observations critiques sur ce commentaire par le citoyen Palissot.

t. XI. Résumé de l'éditeur sur Corneille et sur son commentateur. Extrait du Discours prononcé par à l'Académie françois, le 2 janvier 1685, jour de la réception de Thomas Corneille, choisi pour remplacer Pierre Corneille, son frère. Éloge de P. Corneille, qui, au jugement de l'Académie des sciences, belles-lettres, et arts, de Rouen, a remporé le prix d'éloquence donné en 1768. Par M. Gaillard. Extrait des Mémoires pour servir à l'histoire de notre literature, par le citoyen Palissot. Poésies diverses.--t. XII. L'imitation de Jésus-Christ, traduite et paraphrasée en vers françois.

Travels to discover the source of the Nile in the years 1768, 1769, 1770, 1771, 1772, & 1773.

Vol. 8 contains the plates and maps.

Rapid determination of the active leflunomide metabolite A77 1726 in human plasma by high-performance liquid chromatography

A simple method for the measurement of the active leflunomide metabolite A77 1726 in human plasma by HPLC is presented. The sample workup was simple, using acetonitrile for protein precipitation. Chromatographic separation of A77 1726 and the internal standard, alpha-phenylcinnamic acid, was achieved using a C-18 column with UV detection at 305 nm. The assay displayed reproducible linearity for A77 1726 with determination coefficients (r(2)) > 0.997 over the concentration range 0.5-60.0 mug/ml. The reproducibility (%CV) for intra- and inter-day assays of spiked controls was

Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis

Aims To investigate the concentration-effect relationship and pharmacokinetics of leflunomide in patients with rheumatoid arthritis (RA). Methods Data were collected from 23 RA patients on leflunomide therapy (as sole disease modifying antirheumatic drug (DMARD)) for at least 3 months. Main measures were A77 1726 (active metabolite of leflunomide) plasma concentrations and disease activity measures including pain, duration/intensity of morning stiffness, and SF-36 survey. A population estimate was sought for apparent clearance (CL/F ) and volume of distribution was fixed (0.155 l kg(-1)). Factors screened for influence on CL/F were weight, age, gender and estimated creatinine clearance. Results Significantly higher A77 1726 concentrations were seen in patients with less swollen joints and with higher SF-36 mental summary scores than in those with measures indicating more active disease (P < 0.05); concentration-effect trends were seen with five other disease activity measures. Statistical analysis of all disease activity measures showed that mean A77 1726 concentrations in groups with greater control of disease activity were significantly higher than those in whom the measures indicated less desirable control (P < 0.05). There was large between subject variability in the dose-concentration relationship. A steady-state infusion model best described the pharmacokinetic data. Inclusion of age as a covariate decreased interindividual variability (P < 0.01), but this would not be clinically important in terms of dosage changes. Final parameter estimate (% CV interindividual variability) for CL/F was 0.0184 l h(-1) (50%) (95% CI 0.0146, 0.0222). Residual (unexplained) variability (% CV) was 8.5%. Conclusions This study of leflunomide in patients using the drug clinically indicated a concentration-effect relationship. From our data, a plasma A77 1726 concentration of 50 mg l(-1) is more likely to indicate someone with less active disease than is a concentration around 30 mg l(-1). The marked variability in pharmacokinetics suggests a place for individualized dosing of leflunomide in RA therapy.

Global compilation of benthic data sets I

Approaches to quantify the organic carbon accumulation on a global scale generally do not consider the small-scale variability of sedimentary and oceanographic boundary conditions along continental margins. In this study, we present a new approach to regionalize the total organic carbon (TOC) content in surface sediments (<5 cm sediment depth). It is based on a compilation of more than 5500 single measurements from various sources. Global TOC distribution was determined by the application of a combined qualitative and quantitative-geostatistical method. Overall, 33 benthic TOC-based provinces were defined and used to process the global distribution pattern of the TOC content in surface sediments in a 1°x1° grid resolution. Regional dependencies of data points within each single province are expressed by modeled semi-variograms. Measured and estimated TOC values show good correlation, emphasizing the reasonable applicability of the method. The accumulation of organic carbon in marine surface sediments is a key parameter in the control of mineralization processes and the material exchange between the sediment and the ocean water. Our approach will help to improve global budgets of nutrient and carbon cycles.

Levantamento preliminar dos nemátodes anisaquídeos presentes no Gorz, Pagellus bogaraveo, (Br nnich, 1768), no estado selvagem na Região Autònoma da Madeira

Dissertação de mest. em Aquacultura, Faculdade de Ciências do Mar e do Ambiente, Univ. do Algarve, 2001

Uma ou duas gramáticas de Português Língua Estrangeira (PLE)? A New Portuguese Grammar in Four Parts (Londres, 1768), de António Vieira, e a Nouvelle Gramma ire Portugaise (Paris, 1810), de Alexandre Marie Sané

Serão visadas, neste artigo, as gramáticas A New Portuguese Grammar in four parts (Londres, 1768), de António Vieira, e Nouvelle Grammaire Portugaise (Paris, 1810), de Alexandre Marie Sané, esta considerada à época uma simples tradução francesa daquela, que é um marco dos estudos gramaticais de PLE. Pretende-se analisar esta relação entre as duas obras, evidenciada por G. Hamonière e até hoje não discutida; por outro lado, analisar o contexto específico de edição, redacção e concepção em que se situam as gramáticas de línguas estrangeiras, contexto que difere (do ponto de vista didáctico, teórico e historiográfico) da restante produção gramatical em língua materna.