Survival after somatostatin based radiopeptide therapy with (90)Y-DOTATOC vs. (90)Y-DOTATOC plus (177)Lu-DOTATOC in metastasized gastrinoma.

We aimed to explore the effects of (90)Y-DOTATOC and (90)Y-DOTATOC plus (177)Lu-DOTATOC on survival of patients with metastasized gastrinoma. Patients with progressive metastasized gastrinoma were treated with repeated cycles of (90)Y-DOTATOC or with cycles alternating between (90)Y-DOTATOC and (177)Lu-DOTATOC until tumor progression or permanent toxicity. Multivariable Cox regression analyses were used to study predictors of survival. A total of 36 patients were enrolled; 30 patients received (90)Y-DOTATOC (median activity per patient 11.8GBq; range: 6.1-62.2GBq) and 6 patients received (90)Y-DOTATOC plus (177)Lu-DOTATOC (median activity per patient: 14.8GBq; range: 7.4-14.8GBq). Response was found in 26 patients (72.2%), including morphological (n=12, 33.3%), biochemical (n=14, 38.9%) and/or clinical response (n=6, 16.2%). A total of 21 patients (58.3%) experienced hematotoxicity grade 1/2, while 1 patient (2.8%) experienced hematotoxicity grade 3; no grade 4 hematotoxicity occurred. Furthermore, 2 patients (5.6%) developed grade 4 renal toxicity; no grade 5 renal toxicity occurred. Responders had a significantly longer median survival from time of enrollment than non-responders (45.1 months, range: 37.1-53.1 months vs. 12.6 months, range: 11.0-14.2, hazard ratio: 0.12 (0.027-0.52), p=0.005). Additionally, there was a trend towards longer median survival with (90)Y-DOTATOC plus (177)Lu-DOTATOC as compared to (90)Y-DOTATOC alone (60.2 months, range: 19.8-100.6 months vs. 27.0 months, range: 4.0-50.0, hazard ratio: 0.21 (0.01-3.98), p=0.16). Response to (90)Y-DOTATOC and (90)Y-DOTATOC plus (177)Lu-DOTATOC therapy is associated with a longer survival in patients with metastasized gastrinoma. Both treatment regimens are promising tools for management of progressive gastrinoma.

Moises Hirschl : sein Leben u. Wirken ; zur Feier seines 90. Geburtstages, 3. April 1880 (8. Tag d. Osterfestes 5640)

hrsg. von Samuel Hirsch

Ms. Barth. 90 - Theologisch-kanonistische Sammelhandschrift

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Osteotomy of the distal femur. Surgical technique using the LCP Pediatric Condylar Plate 90°.

OBJECTIVE Correction of all kind of deformities at the distal part of the femur (supracondylar). INDICATIONS Flexion, extension osteotomies, and varus or valgus, and external or internal rotation osteotomies, and shortening osteotomies of the distal femur or combined surgical procedures (e.g., extension and de-rotation osteotomy). CONTRAINDICATIONS Osteotomy through unknown bony process. SURGICAL TECHNIQUE LCP system provides angular stable fixation. POSTOPERATIVE MANAGEMENT Without concomitant surgical procedures of soft tissue (e.g., patellar tendon shortening), early functional rehabilitation is possible with immediate weight bearing (35 kg for small fragment plates and 70 kg for large fragment plates). RESULTS The surgical procedure is safe and is associated with few complications. Overall complication rate in this series of patients was 3%.

Henriette Goldschmidt : zu ihrem 90. Geburtstage am 23. November 1915

Regina Neisser

Moses Gebet : Psalm 90

M. A. Klausner

Justizrat Dr. Max Loeb, Mainz [Illustration] : Medaillen in gegossener Bronze (90 mm)

Scan von Monochrom-Mikroform

Lehre uns unsere Tage zählen : der Psalm 90

Heymann Steinthal

Ms. hebr. oct. 90 - [Sammelband in 5 Teilen: Handschriftenkonvolut]

Vorbesitzer: Abraham Merzbacher

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 90 - Kondolenzschreiben nach dem Tod von Heinrich Floris Schopenhauer im April 1805

veröffentlicht in: Schopenhauer, Arthur : Arthur Schopenhauers sämtliche Werke - München : Piper - Bd. 14 : Der Briefwechsel Arthur Schopenhauers ; 1 (1799 - 1849), Nr. 21;

Ms. Praed. 90 - Summa super titulis Decretalium

Vorbesitzer: Johannes Smizkil; Dominikanerkloster Frankfurt am Main

Fragm. lat. VII 90 - De bello Iudaico (L. VII c. 61 - 66)

Trägerband: Q 16/109; Vorbesitzer: Philippus Jacobus Otto

Die Wirkungen des Winters 90/91 an der Riviera

Paul Bräuer

Ms.Ff.F.Stoltze 3. 90 - Brief von Julius Gerlach an Friedrich Stoltze

Reaktion auf Stoltzes Homburg-Gedicht, Schudt, Emanuel Geibel