9 a 12 años. Información básica para la crianza

Información elaborada a partir de: Proyecto de Humanización de la Atención Perinatal en Andalucía; Plan para la Promoción de la Actividad Física y la Alimentación Equilibrada; Plan Integral de Obesidad Infantil de Andalucía; Programas de Promoción de Salud Bucodental "Sonrisitas" y "Aprende a sonreir"; Plan Integral de Atención a la Accidentabilidad de Andalucía; Plan Integral de Tabaquismo de Andalucía; Plan Integral de Oncología de Andalucía. Publicado en el Portal Web de Ventana Abierta a la familia: www.juntadeandalucia.es/salud/ventanafamilias

Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior.

The dynamic properties of helix 12 in the ligand binding domain of nuclear receptors are a major determinant of AF-2 domain activity. We investigated the molecular and structural basis of helix 12 mobility, as well as the involvement of individual residues with regard to peroxisome proliferator-activated receptor alpha (PPARalpha) constitutive and ligand-dependent transcriptional activity. Functional assays of the activity of PPARalpha helix 12 mutants were combined with free energy molecular dynamics simulations. The agreement between the results from these approaches allows us to make robust claims concerning the mechanisms that govern helix 12 functions. Our data support a model in which PPARalpha helix 12 transiently adopts a relatively stable active conformation even in the absence of a ligand. This conformation provides the interface for the recruitment of a coactivator and results in constitutive activity. The receptor agonists stabilize this conformation and increase PPARalpha transcription activation potential. Finally, we disclose important functions of residues in PPARalpha AF-2, which determine the positioning of helix 12 in the active conformation in the absence of a ligand. Substitution of these residues suppresses PPARalpha constitutive activity, without changing PPARalpha ligand-dependent activation potential.

[12 phot. des Alpes suisses (Valais et canton de Berne) par J. Beck, don E. Reclus en 1886]

Donateur : Reclus, Élisée (1830-1905)

A study of personality in children aged 8-12 years: Comparing self- and partents' ratings

This study was designed to investigate personality development with children aged 8 to 12. For this purpose, Children's self-perceptions were compared to parent's ratings. 506 children and their parents completed a selection of 38 questions from the Hierarchical Personality Inventory for Children (HiPIC). Results showed an age-related increase in the structural congruence of children's ratings compared to parents' ratings and a highly significant increase in the reliabilities of both parents' and children's assessments. The mean correlation between the children's self-descriptions and parents' ratings were higher for Conscientiousness and Imagination than for Extraversion, Benevolence and Emotional Stability and significantly increased with the children's age. Mean-levels decreased with age for Imagination in parents' ratings and for Benevolence, Conscientiousness, and Imagination, in children's ratings. This study showed that personality development from 8 to 12 years goes along with an increase in the agreement between the children's self-perceptions and the parents' perceptions of the children's personality.

Molecular testing for fragile X: analysis of 5062 tests from 1105 fragile X families--performed in 12 clinical laboratories in Spain.

Fragile X syndrome is the most common inherited form of intellectual disability. Here we report on a study based on a collaborative registry, involving 12 Spanish centres, of molecular diagnostic tests in 1105 fragile X families comprising 5062 individuals, of whom, 1655 carried a full mutation or were mosaic, three cases had deletions, 1840 had a premutation, and 102 had intermediate alleles. Two patients with the full mutation also had Klinefelter syndrome. We have used this registry to assess the risk of expansion from parents to children. From mothers with premutation, the overall rate of allele expansion to full mutation is 52.5%, and we found that this rate is higher for male than female offspring (63.6% versus 45.6%; P < 0.001). Furthermore, in mothers with intermediate alleles (45-54 repeats), there were 10 cases of expansion to a premutation allele, and for the smallest premutation alleles (55-59 repeats), there was a 6.4% risk of expansion to a full mutation, with 56 repeats being the smallest allele that expanded to a full mutation allele in a single meiosis. Hence, in our series the risk for alleles of <59 repeats is somewhat higher than in other published series. These findings are important for genetic counselling.

12/11/19, bateaux viviers à Paris : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56890

1.° Caii Plinii Secundi epistolarum libri decem : primi initium et decimi finis desiderantur. — 2.° Ejusdem panegyricus Trajano dictus. — 3.° Latini Pacati Drepanii panegyricus Theodosio dictus. — 4.° Claudii Mamertini Juliano Imperatori gratiarum actio de Consulatu suo. — 5.° Nazarii panegyricus Constantino, Caesari, dictus. — 6.° Eumenii gratiarum actio Constantino, Augusto, Flaviensium nomine. — 7.° Ejusdem panegyricus Constantino, Augusto, dictus. — 8.° Incerti authoris panegyricus Maximiano et Constantino dictus. — 9.° Eumenii panegyricus Constantio, Caesari, dictus. — 10.° Ejusdem oratio pro restaurandis scholis. — 11.° Claudii Mamertini panegyricus Maximiano, Augusto, dictus. — 12.° Genethliacus Maximiani : authore eodem. — 13.° Incerti authoris panegyricus Constantino, Augusto, dictus : finis desideratur.

Bigotianus

Petrus de Alvernia, de motibus animalium, de longit. et brev. vite (5v), de morte et vita (7v), de juventute et senecta (9), de respiratione (12).

Pour gardes, fragments de comptes de la ville de Paris en 1365.