430 resultados para 1194
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Mode of access: Internet.
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Added half t.p., title in Greek.
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Published anonymously.
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Mode of access: Internet.
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Description based on pt.1.
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Includes bibliographical references
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Mode of access: Internet.
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A prática educativa na escola está carregada de uma postura tradicional e bancária , conforme aparece em várias obras de Freire, ainda que novas tecnologias sejam introduzidas em seu cotidiano pedagógico. A ênfase à informação em detrimento da construção do conhecimento e saberes, na verdade, afasta o aluno, particularmente nas escolas públicas, de apropriar-se dos instrumentos significativos de sua elaboração. Nesse sentido, dentro da linha de Políticas e Gestões Educacionais, esse trabalho se propõe à reflexão do espaço da escola no diálogo com a cidade, isto é, à possibilidade de protagonismo social no desenvolvimento do aluno. O procedimento da pesquisa fundamenta-se no estudo dos projetos de educação ambiental desenvolvidos na rede municipal de Mauá através dos registros e relatos descritivos das avaliações das escolas dessas atividades, de seus Projetos Políticos Pedagógicos e do Programa de Educação Ambiental de Mauá da Secretaria Municipal de Educação. O trabalho Dos muros da escola à abertura para a cidade foi desenvolvido de forma a entendermos o espaço geográfico, considerando sua territorialização e o conceito de espaço simbólico. Dessa forma, podemos compreender como a relação escola/espaço território e o Programa de Educação Ambiental desenvolvido em escolas da rede pública da cidade de Mauá aparece na atuação de um em relação ao outro. A metodologia de trabalho usada foi exploratória, de natureza bibliográfica e documental. A pesquisa buscou perceber a abordagem dialógica que se estabelece com a cidade a partir da conceituação do espaço simbólico da escola no processo ensino-aprendizagem. O Programa de Educação Ambiental e as escolas, de acordo com seus Projetos Políticos Pedagógicos se propõem, ainda que empiricamente, a trabalhar nessa direção. A prática pedagógica, como demonstraram algumas atividades, mesmo tratando do tema de forma sem a consciência diferenciada , aponta um avanço nesse sentido. Os textos coletivos, a participação solidária, são elementos que nos permitem concluir dessa forma. As respostas das crianças foram significativas, embora tenhamos apontado as dificuldades na execução dos procedimentos pedagógicos. Por tratar-se de algo novo, não só como proposta, o Programa de Educação Ambiental exigiu a capacidade de lidar com ações integrada e integradora, ou seja, mudança de subjetividade dos distintos atores envolvidos no processo. O tema poderia se tornar por demais abrangente e, dessa forma, perder-se em generalidades. Assim, alguns aspectos relevantes foram apontados sem, no entanto, partir para um maior aprofundamento a fim de garantir a objetividade do trabalho. A instituição escolar está presente de corpo e alma na cidade e, ainda que, a temática ambiental esteja presente em seu cotidiano ela se faz de maneira formal e informativa. Todos falam em meio ambiente, entretanto poucos internalizam os valores de um ambiente saudável e próprio para o desenvolvimento humano da maioria que produz a riqueza das nações. Consideradas as observações apontadas, o trabalho apresentou elementos que devem ser analisados com maior propriedade, isto é, com maior extensão, como proposta de continuidade da pesquisa.
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Magnification factors specify the extent to which the area of a small patch of the latent (or `feature') space of a topographic mapping is magnified on projection to the data space, and are of considerable interest in both neuro-biological and data analysis contexts. Previous attempts to consider magnification factors for the self-organizing map (SOM) algorithm have been hindered because the mapping is only defined at discrete points (given by the reference vectors). In this paper we consider the batch version of SOM, for which a continuous mapping can be defined, as well as the Generative Topographic Mapping (GTM) algorithm of Bishop et al. (1997) which has been introduced as a probabilistic formulation of the SOM. We show how the techniques of differential geometry can be used to determine magnification factors as continuous functions of the latent space coordinates. The results are illustrated here using a problem involving the identification of crab species from morphological data.
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Free Paper Sessions Design. Retrospective analysis. Purpose. To assess the prevalence of center-involving diabetic macular oedema (CIDMO) and risk factors. Methods. Retrospective review of patients who were screen positive for maculopathy (M1) during 2010 in East and North Birmingham. The CIDMO was diagnosed by qualitative identification of definite foveal oedema on optical coherence tomography (OCT). Results. Out of a total of 15,234 patients screened, 1194 (7.8%) were screen positive for M1 (64% bilateral). A total of 137 (11.5% of M1s) were diagnosed with macular oedema after clinical assessment. The OCT results were available for 123/137; 69 (56.1%) of these had CI-DMO (30 bilateral) which is 0.5% of total screens and 5.8% of those screen positive for M1. In those with CIDMO 60.9% were male and 63.8% Caucasian; 90% had type 2 diabetes and mean diabetes duration was 20 years (SD 9.7, range 2-48). Mean HbA1c was 8.34%±1.69, with 25% having an HbA1c =9%. Furthermore, 62% were on insulin, 67% were on antihypertensive therapy, and 64% were on a cholesterol-lowering drug. A total of 37.7% had an eGFR between 30% and 60% and 5.8% had eGFR <30. The only significant difference between the CIDMO and non-CIDMO group was mean age (67.83±12.26 vs 59.69±15.82; p=0.002). A total of 65.2% of those with CIDMO also had proliferative or preproliferative retinopathy in the worst eye and 68.1% had subsequently been treated with macular laser at the time of data review. Conclusions. The results show that the prevalence of CIDMO in our diabetic population was 0.5%. A significant proportion of macula oedema patients were found to have type 2 diabetes with long disease duration, suboptimal glycemic and hypertensive control, and low eGFR. The data support that medical and diabetic review of CIDMO patients is warranted particularly in the substantial number with poor glycemic control and if intravitreal therapies are indicated.
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Back in 2003, we published ‘MAX’ randomisation, a process of non-degenerate saturation mutagenesis using exactly 20 codons (one for each amino acid) or else any required subset of those 20 codons. ‘MAX’ randomisation saturates codons located in isolated positions within a protein, as might be required in enzyme engineering, or else on one face of an alpha-helix, as in zinc finger engineering. Since that time, we have been asked for an equivalent process that can saturate multiple, contiguous codons in a non-degenerate manner. We have now developed ‘ProxiMAX’ randomisation, which does just that: generating DNA cassettes for saturation mutagenesis without degeneracy or bias. Offering an alternative to trinucleotide phosphoramidite chemistry, ProxiMAX randomisation uses nothing more sophisticated than unmodified oligonucleotides and standard molecular biology reagents. Thus it requires no specialised chemistry, reagents nor equipment and simply relies on a process of saturation cycling comprising ligation, amplification and digestion for each cycle. The process can encode both unbiased representation of selected amino acids or else encode them in pre-defined ratios. Each saturated position can be defined independently of the others. We demonstrate accurate saturation of up to 11 contiguous codons. As such, ProxiMAX randomisation is particularly relevant to antibody engineering.
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* Работа поддержана грантами РФФИ 09-01-00032, 07-07-00022 и грантом АВЦП Рособразования 2.1.1/3235
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Background: Food allergy affects quality of life in patients and parents and mothers report high levels of anxiety and stress. Cognitive Behaviour Therapy (CBT) may be helpful in reducing the psychological impact of food allergy. The aim of this study was to examine the appropriateness and effectiveness of CBT to improve psychological outcomes in parents of children with food allergy. Methods: Five parents (all mothers) from a local allergy clinic requested to have CBT; six mothers acted as controls and completed questionnaires only. CBT was individual and face-to face and lasted 12 weeks. All participants completed measures of anxiety and depression, worry, stress, general mental health, generic and food allergy specific quality of life at baseline and at 12 weeks. Results: Anxiety, depression and worry in the CBT group significantly reduced and overall mental health and QoL significantly improved from baseline to 12 weeks (all p < 0.05) in mothers in the CBT group; control group scores remained stable. Conclusions: CBT appears to be appropriate and effective in mothers of children with food allergy and a larger randomised control trial now needs to be conducted. Ways in which aspects of CBT can be incorporated into allergy clinic visits need investigation.
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The moral foundation of capitalism should be reconsidered. Modern capitalism is disembedded from the social and cultural norms of society and produced a deep financial, ecological and social crisis. Competitiveness is the prevailing ideology of today’s business and economic policy. Companies, regions, and national economies seek to improve their productivity and gain competitive advantage. But these efforts often produce negative effects on various stakeholders at home and abroad. Competitiveness involves self-interest and aggressivity and produces monetary results at the expense of nature, society and future generations The collaborative enterprise framework promotes a view in which economic agents care about others and themselves and aim to create values for all the participants in their business ecosystems. Their criterion of success is mutually satisfying relationships with the stakeholders. New results of positive psychology and the Homo reciprocans model of behavioral sciences support this approach. The economic teachings of world religions challenge the way capitalism is functioning, and their corresponding perspectives are worthy of consideration. They represent life-serving modes of economizing which can assure the livelihood of human communities and the sustainability of natural ecosystems. Ethics and the future of capitalism are strongly connected. If we want to sustain capitalism for a long time we have to create a less violent, more caring form of it.
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The purpose of this research is to outline several of the issues that serve as barriers to women participating in nontraditional career and technical education in an effort to prompt solution based strategies on the part of career and technical instructors, adult education practitioners, and administrators.