Breve, y devota descripcion de la gloriosa celda del padre S. Luis Beltran : acreditada con singulares prodigios, y favores Celestiales ...

Índice

Preclarissimum mathematicarû opus : in quo continêtur... thome Bravardini aritmetica [et] eiusdez geometria necnô et... Pisani carturiensis perspectiva... ; Accuratissime emêdatu

Il. xil. de tablas y figuras geometricas y de perspectiva

Compendio historial o relacion breve y veridica del portentoso santuario y camara angelical de Nuestra Señora de Monserrate : dirigido a los piadosos devotos..

Fecha de 1758 tomada del permiso de impresión en el v. de la port

Sumario de los reyes de España [Texto impreso]

Palau atribuye la obra a Juan Rodríguez de Cuenca

Discurso sobre el origen, antigüedad y progresos de los positos o graneros publicos de los pueblos [Texto impreso]

Sign. : [calderón]4, A-M4, O3, []20

Ioannis Petri Fontanellae ... Decisiones sacri regii senatus Cathaloniae : [Texto impreso] tomus secundus ...cum nouo repertorio generali materiarum ac rerum notabilium ...

Marca tip. en port

Exercitia spiritualia... [Texto impreso]

Colofón

Liber de triplici regione claustralium [et] Spirituali exercitio monachorum [Texto impreso] : omnibus religiosis nô minus utilis [que] necessarius

Port

Ortografia española : [Texto impreso] fijamente ajustada a la naturaleza inuariable de cada una de las letras

Contiene: Apologia de Ortografia precedente, contra las instancias vulgares recogidas por Don Salvador Josef Mañer

Casus longi super sexto libro Decretalium et super Clementinis [Texto impreso]

Tit. tomado del Craviotto II, 4895

Libro primero, de Arithmetica Algebratica, enel qual se contiene el arte Mercantiuol, con otras muchas Reglas del arte menor, y la Regla del Algebra, vulgarmente llamada Arte mayor, o Regla de la cosa ... [Texto impreso] ...]

Marca tip. en v. de port. y en v. de última h.

Tomus IIII Operum D. Aurelii Augustini Hipponensis Episcopi : [Texto impreso] complectens reliqua ton didaktikon per Theologos louanienses ab innumeris mendis repurgatus : cum appendice eiusdem tomi

Marca tip. en port

Antiquités d'Herculanum [Texto impreso]

En port. de la parte de texto consta año 1780

Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

Muscarinic acetylcholine receptors are members of the G protein-coupled receptor superfamily expressed in neurons, cardiomyocytes, smooth muscle, and a variety of epithelia. Five subtypes of muscarinic acetylcholine receptors have been discovered by molecular cloning, but their pharmacological similarities and frequent colocalization make it difficult to assign functional roles for individual subtypes in specific neuronal responses. We have used gene targeting by homologous recombination in embryonic stem cells to produce mice lacking the m1 receptor. These mice show no obvious behavioral or histological defects, and the m2, m3, and m4 receptors continue to be expressed in brain with no evidence of compensatory induction. However, the robust suppression of the M-current potassium channel activity evoked by muscarinic agonists in sympathetic ganglion neurons is completely lost in m1 mutant mice. In addition, both homozygous and heterozygous mutant mice are highly resistant to the seizures produced by systemic administration of the muscarinic agonist pilocarpine. Thus, the m1 receptor subtype mediates M current modulation in sympathetic neurons and induction of seizure activity in the pilocarpine model of epilepsy.

The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel

Inwardly rectifying potassium (K+) channels gated by G proteins (Kir3.x family) are widely distributed in neuronal, atrial, and endocrine tissues and play key roles in generating late inhibitory postsynaptic potentials, slowing the heart rate and modulating hormone release. They are directly activated by Gβγ subunits released from G protein heterotrimers of the Gi/o family upon appropriate receptor stimulation. Here we examine the role of isoforms of pertussis toxin (PTx)-sensitive G protein α subunits (Giα1–3 and GoαA) in mediating coupling between various receptor systems (A1, α2A, D2S, M4, GABAB1a+2, and GABAB1b+2) and the cloned counterpart of the neuronal channel (Kir3.1+3.2A). The expression of mutant PTx-resistant Gi/oα subunits in PTx-treated HEK293 cells stably expressing Kir3.1+3.2A allows us to selectively investigate that coupling. We find that, for those receptors (A1, α2A) known to interact with all isoforms, Giα1–3 and GoαA can all support a significant degree of coupling to Kir3.1+3.2A. The M4 receptor appears to preferentially couple to Giα2 while another group of receptors (D2S, GABAB1a+2, GABAB1b+2) activates the channel predominantly through Gβγ liberated from GoA heterotrimers. Interestingly, we have also found a distinct difference in G protein coupling between the two splice variants of GABAB1. Our data reveal selective pathways of receptor activation through different Gi/oα isoforms for stimulation of the G protein-gated inwardly rectifying K+ channel.