A graphically-programmed, microprocessor-based industrial controller /

Vita.

Recommendations for CAMAC serial highway drivers and LAM graders for the SCCL2 serial crate controller : adopted by U.S. NIM Committee (Nuclear Instrumentation Methods) and ESONE Committee of European Laboratories (European Standards on Nuclear Electronics).

Issued Jan. 1978.

Constrained input-output simulations of energy restrictions in the food and fiber system /

Tables.

Constrained attitudes,

Coram populo.--On the brink of politics.--Rusticity and contemplation.--The humdrum of revolt.--The usual thing.--Impatient "culture" and the literal mind.--Literary class distinctions.--The art of disparagement.--International impressionism.--Quotation and allusion.--Occasional verse.

Biennial report of the State Controller.

Description based on: 40th fiscal year ending June 30, 1889, and 41st fiscal year ending June 30, 1890; title from cover.

A controller display technique for a terminal air traffic control system.

"Contract no. FAA/BRD-15, Task order no. 14. Prepared for Federal Aviation Agency, Bureau of Research and Development, Systems Analysis Division."

Annual report of the State Controller, State of California, for the fiscal year ended June 30 ...

Title varies slightly.

On the motion of points constrained and resisted, and on the motion of a rigid body : the second part a new edition of a Treatise on dynamics.

Mode of access: Internet.

Report of the controller of the state of Nevada

Imprint varies: Reports for 1878-1879 printed by A.L. Bancroft & Company, San Francisco

Annual report of the School Controller of the School District of Philadelphia.

Latest issue consulted: 9th (1920).

Aviation industry, a call to action : a joint FAA industry partnership to improve pilot/controller communications.

Shipping list no.: 89-297-P.

Cycloadditions of isobenzofuran to a constrained template bearing neighboring dienophiles

A high yielding synthesis of the pentacyclic diene-dione 1 has enabled investigation of its reactivity as a double dienophile in Diels-Alder [4+2] cycloadditions with isobenzofuran, leading to novel and highly symmetrical three-sided cavitands 3 and 4.

Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries

A major problem in de novo design of enzyme inhibitors is the unpredictability of the induced fit, with the shape of both ligand and enzyme changing cooperatively and unpredictably in response to subtle structural changes within a ligand. We have investigated the possibility of dampening the induced fit by using a constrained template as a replacement for adjoining segments of a ligand. The template preorganizes the ligand structure, thereby organizing the local enzyme environment. To test this approach, we used templates consisting of constrained cyclic tripeptides, formed through side chain to main chain linkages, as structural mimics of the protease-bound extended beta-strand conformation of three adjoining amino acid residues at the N- or C-terminal sides of the scissile bond of substrates. The macrocyclic templates were derivatized to a range of 30 structurally diverse molecules via focused combinatorial variation of nonpeptidic appendages incorporating a hydroxyethylamine transition-state isostere. Most compounds in the library were potent inhibitors of the test protease (HIV-1 protease). Comparison of crystal structures for five protease-inhibitor complexes containing an N-terminal macrocycle and three protease-inhibitor complexes containing a C-terminal macrocycle establishes that the macrocycles fix their surrounding enzyme environment, thereby permitting independent variation of acyclic inhibitor components with only local disturbances to the protease. In this way, the location in the protease of various acyclic fragments on either side of the macrocyclic template can be accurately predicted. This type of templating strategy minimizes the problem of induced fit, reducing unpredictable cooperative effects in one inhibitor region caused by changes to adjacent enzyme-inhibitor interactions. This idea might be exploited in template-based approaches to inhibitors of other proteases, where a beta-strand mimetic is also required for recognition, and also other protein-binding ligands where different templates may be more appropriate.

Multiple paths extraction in images using a constrained expanded trellis

Single shortest path extraction algorithms have been used in a number of areas such as network flow and image analysis. In image analysis, shortest path techniques can be used for object boundary detection, crack detection, or stereo disparity estimation. Sometimes one needs to find multiple paths as opposed to a single path in a network or an image where the paths must satisfy certain constraints. In this paper, we propose a new algorithm to extract multiple paths simultaneously within an image using a constrained expanded trellis (CET) for feature extraction and object segmentation. We also give a number of application examples for our multiple paths extraction algorithm.

A safety catch linker for Fmoc-based assembly of constrained cyclic peptides

A new safety-catch linker for Fmoc solid-phase peptide synthesis of cyclic peptides is reported. The linear precursors were assembled on a tert-butyl protected catechol derivative using optimized conditions for Fmoc-removal. After activation of the linker using TFA, neutralization of the N-terminal amine induced cyclization with concomitant cleavage from the resin yielding the cyclic peptides in DMF solution. Several constrained cyclic peptides were synthesized in excellent yields and purities. Copyright (c) 2005 European Peptide Society and John Wiley & Sons, Ltd.