NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats

The aim of the present study was to investigate the role of the lateral hypothalamus (LH) and its local glutamatergic neurotransmission in the cardiovascular adjustments observed when rats are submitted to acute restraint stress. Bilateral microinjection of the nonspecific synaptic inhibitor CoCl2 (0.1 nmol in 100 nL) into the LH enhanced the heart rate (HR) increase evoked by restraint stress without affecting the blood pressure increase. Local microinjection of the selective N-methyl-d-aspartate (NMDA) glutamate receptor antagonist LY235959 (2 nmol in 100 nL) into the LH caused effects that were similar to those of CoCl2. No changes were observed in the restraint-related cardiovascular response after a local microinjection of the selective non-NMDA glutamatergic receptor antagonist NBQX (2 nmol in 100 nL) into the LH. Intravenous administration of the muscarinic cholinergic receptor antagonist homatropine methyl bromide (0.2 mg/kg), a quaternary ammonium drug that does not cross the blood-brain barrier, abolished the changes in cardiovascular responses to restraint stress following LH treatment with LY235959. In summary, our findings show that the LH plays an inhibitory role on the HR increase evoked by restraint stress. Present results also indicate that local NMDA glutamate receptors, through facilitation of cardiac parasympathetic activity, mediate the LH inhibitory influence on the cardiac response to acute restraint stress. The bilateral microinjection of the CoCl2 or LY235959 into the LH enhanced the HR increase evoked by restraint stress without affecting the blood pressure increase. Intravenous administration of the homatropine methyl bromide abolished the changes in cardiovascular responses to restraint stress following LH treatment with LY235959. These results suggest that such LH influence is mediated by local NMDA glutamate receptors and involves parasympathetic nervous activation. © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Performance analysis of smart grid communication protocol DNP3 over TCP/IP in a heterogeneous traffic environment

This paper presents simulation results of the DNP3 communication protocol over a TCP/IP network, for Smart Grid applications. The simulation was performed using the NS-2 network simulator. This study aimed to use the simulation to verify the performance of the DNP3 protocol in a heterogeneous LAN. Analyzing the results it was possible to verify that the DNP3 over a heterogeneous traffic network, with communication channel capacity between 60 and 85 percent, it works well with low packet loss and low delay, however, with traffic values upper 85 percent, the DNP3 usage becomes unfeasible because the information lost, re-transmissions and latency are significantly increased. © 2013 IEEE.

Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor

Systemic administration of cannabidiol (CBD) is able to attenuate cardiovascular responses to acute restraint stress through activation of 5-HT1A receptors. Previous results from our group suggest that the bed nucleus of the stria terminalis (BNST) is involved in the antiaversive effects of the CBD. Moreover, it has been proposed that synapses within the BNST influence restraint-evoked cardiovascular changes, in particular by an inhibitory influence on the tachycardiac response associated to restraint stress. Thus, the present work investigated the effects of CBD injected into the BNST on cardiovascular changes induced by acute restraint stress and if these effects would involve the local activation of 5-HT1A receptors. The exposition to restraint stress increased both blood pressure and heart rate (HR). The microinjection of CBD (30 and 60nmol) into the BNST enhanced the restraint-evoked HR increase, in a dose-dependent manner, without affecting the pressor response. The selective 5-HT1A receptor antagonist WAY100635 by itself did not change the cardiovascular responses to restraint stress, but blocked the effects of CBD. These results showed that CBD microinjected into the BNST enhanced the HR increase associated with acute restraint stress without affecting the blood pressure response. Although these results are not in agreement with those observed after systemic administration of CBD, they are similar to effects observed after reversible inactivation of the BNST. Moreover, similar to the effects observed after systemic administration, CBD effects in the BNST seem to depend on activation of 5-HT1A receptors. © 2012 Elsevier B.V. and ECNP.

Sustancias y desechos peligrosos: impacto del movimiento transfronterizo hacia la región de América Latina y el Caribe y posibles acciones preventivas y de control. Parte I: la realidad del tráfico ilícito y los mecanismos institucionales para su prevención = Hazardous products and wastes: impact of transboundary movement towards the Latin American and Caribbean region and possibilities for preventing and controlling it. Part one: illegal traffic and institutional machinery for preventing it

Incluye Bibliografía

Caribbean maritime traffic model

Includes bibliography

Measures for controlling traffic congestion

Traffic congestion has become a severe scourge in large cities, in both the industrialized and developing countries. Increasing demand for urban transport and transit has led to longer travel times, and a greater incidence of accidents, environmental problems and deterioration in the quality of life than is considered acceptable for citizens. A multidisciplinary approach is required in order to keep the negative effects of congestion under control and to ensure standards of living remain sustainable. In view of the seriousness of the problem, ECLAC with the support of the German Agency for Technical Cooperation (GTZ) is carrying out a project to study measures that contribute to traffic control. As part of this project, initiatives regarding the supply of, and the demand for, transport have been examined, and a programme to disseminate information is being conducted.For further information, please contact Mr Alberto Bull .

Alternatives for controlling urban traffic congestion

Traffic congestion is nothing new in Latin American cities but has worsened in recent years. Eliminating it is a pipedream, but it should be brought under control. Many economists and transport planners think electronic road pricing would be the best way of tackling it, now that the appropriate technology for implementing it is available. On the other hand, experience shows that, for political reasons, it would be better to begin by adopting simpler methods. To start with, simple road pricing would seem to be the best option. But, over 20 years of experience in London and more than six in Santiago, Chile, made it clear that socio-political barriers have to be surmounted before even this option can be applied in practice. There is more political support for measures to control parking, due in part to the fact that the legal powers do not normally extend to restricting the number of parking spaces available to high-income and influential motorists who have the right to park near their offices and who cause a great deal of the congestion whilst getting there. In Latin America, the relative importance of taxis also diminishes the effectiveness of measures geared to parking, since taxis contribute to congestion although but they do not park. The problem of congestion cannot be solved by using tame measures. The time has come for something bolder, i.e., measures that, at the very least, exercise control over those parking spaces, which so far have been beyond the reach of governments and local authorities, ideally, simple road pricing systems would be even more effective.

Investment and port traffic: an analysis of the situation in Spain

The principal objective of this issue of the FAL Bulletin is to look at investments made in the Spanish port system between 1993 and 2010 in order to determine whether there is a direct link between expansion of port facilities and the outcome of competition for traffic.

Traffic congestion: the problem and how to tackle it

As the culmination of a project financed by the Technical Cooperation Agency of the Federal Republic of Germany (GTZ), ECLAC has just published Congestión de tránsito - El problema y cómo enfrentarlo, Cuadernos de la Cepal series, No. 87. The text of 194 pages analyses the negative impacts of congestion and the multidisciplinary efforts that are needed to keep it under control, through the design of appropriate policies and measures. Congestion control is part of the development of a strategic vision of how a city should develop which can make it possible to harmonize the needs of mobility, growth and competitiveness, which are so necessary today and in the future, with the sustainability of cities and the improvement of their quality of life.The task is complex and it is not easy to find appropriate solutions. The present publication presents tools for tackling this crucial problem. Everything indicates that it calls for high professional and leadership qualities on the part of the authorities, and that it must have the active support of the citizens.This edition of the Bulletin presents a summary of the main conclusions of the publication and it is stressed that ECLAC can conduct local workshops to analyze the problem and how to tackle it.

ECLAC contributes with new workshops towards the goal of easing traffic congestion

A number of cities in Latin America played host to workshops on measures for reducing traffic congestion, as part of efforts to publicize the results of a project recently completed by ECLAC, and which received support from the German Agency for Technical Cooperation (GTZ). Congestion is beginning to pose a threat to the quality of life of the cities of the region; the most obvious manifestation of this congestion is the increase in daily travel time, especially in peak hours.The workshops are a contribution to efforts to curb congestion, since they help foster awareness of the extent of the negative consequences generated by the phenomenon, and are a means of publicizing options for dealing with it. This edition of the Bulletin outlines the contents of the workshops and their results. The workshops are offered to urban authorities and other institutions interested in training staff employed in positions involving traffic management.