A conserved role for p48 homologs in protecting dopaminergic neurons from oxidative stress.

Parkinson's disease (PD) is the most common neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons. Both environmental and genetic factors are thought to contribute to the pathogenesis of PD. Although several genes linked to rare familial PD have been identified, endogenous risk factors for sporadic PD, which account for the majority of PD cases, remain largely unknown. Genome-wide association studies have identified many single nucleotide polymorphisms associated with sporadic PD in neurodevelopmental genes including the transcription factor p48/ptf1a. Here we investigate whether p48 plays a role in the survival of DA neurons in Drosophila melanogaster and Caenorhabditis elegans. We show that a Drosophila p48 homolog, 48-related-2 (Fer2), is expressed in and required for the development and survival of DA neurons in the protocerebral anterior medial (PAM) cluster. Loss of Fer2 expression in adulthood causes progressive PAM neuron degeneration in aging flies along with mitochondrial dysfunction and elevated reactive oxygen species (ROS) production, leading to the progressive locomotor deficits. The oxidative stress challenge upregulates Fer2 expression and exacerbates the PAM neuron degeneration in Fer2 loss-of-function mutants. hlh-13, the worm homolog of p48, is also expressed in DA neurons. Unlike the fly counterpart, hlh-13 loss-of-function does not impair development or survival of DA neurons under normal growth conditions. Yet, similar to Fer2, hlh-13 expression is upregulated upon an acute oxidative challenge and is required for the survival of DA neurons under oxidative stress in adult worms. Taken together, our results indicate that p48 homologs share a role in protecting DA neurons from oxidative stress and degeneration, and suggest that loss-of-function of p48 homologs in flies and worms provides novel tools to study gene-environmental interactions affecting DA neuron survival.

Boas práticas do estágio supervisionado de Licenciatura em Educação Física

O presente estudo tem como objetivo discutir as atividades realizadas no Estágio Supervisionado em Educaçao Física para o Ensino Fundamental, a fundamentaçao teórica utilizada para montagem das aulas, além de analisar a participaçao e desenvolvimento dos alunos. Portanto sao discutidas as características das abordagens pedagógicas escolhidas (Construtivista e Desenvolvimentista) e a participaçao dos alunos. Foi possível estabelecer uma comparaçao entre as duas abordagens utilizadas, verificando as variaçoes dos objetivos das aulas, da forma de mistura-la e também as diferentes formas de avaliaçao que aconteceram em funçao da idade dos alunos

Ideología y ciencia en la psicología argentina : Las configuraciones de un themata (1958-1975)

Este artículo propone el concepto de themata para analizar la forma en que los criterios científicos y políticos fueron articulados en la psicología argentina de 1958 a 1975. En este período el themata ideología/ciencia fue fundamental en el establecimiento del estatus epistemológico del saber psicológico de la psiquiatría, psicoanálisis y psicología. Dicho themata fue modulado por la filiación marxista de algunos de los principales autores de esas disciplinas. Se analizarán desde el marco de la historia intelectual y de la ciencia las propues- tas epistemológicas de José Bleger, de la psiquiatría comunista pavloviana y de la psicología estructuralista psicoanalítica, a fin de comprender el papel de los valores epistémicos y no epistémicos en la fundamentación de las prácticas psicológicas

Ideología y ciencia en la psicología argentina : Las configuraciones de un themata (1958-1975)

Este artículo propone el concepto de themata para analizar la forma en que los criterios científicos y políticos fueron articulados en la psicología argentina de 1958 a 1975. En este período el themata ideología/ciencia fue fundamental en el establecimiento del estatus epistemológico del saber psicológico de la psiquiatría, psicoanálisis y psicología. Dicho themata fue modulado por la filiación marxista de algunos de los principales autores de esas disciplinas. Se analizarán desde el marco de la historia intelectual y de la ciencia las propues- tas epistemológicas de José Bleger, de la psiquiatría comunista pavloviana y de la psicología estructuralista psicoanalítica, a fin de comprender el papel de los valores epistémicos y no epistémicos en la fundamentación de las prácticas psicológicas

Boas práticas do estágio supervisionado de Licenciatura em Educação Física

O presente estudo tem como objetivo discutir as atividades realizadas no Estágio Supervisionado em Educaçao Física para o Ensino Fundamental, a fundamentaçao teórica utilizada para montagem das aulas, além de analisar a participaçao e desenvolvimento dos alunos. Portanto sao discutidas as características das abordagens pedagógicas escolhidas (Construtivista e Desenvolvimentista) e a participaçao dos alunos. Foi possível estabelecer uma comparaçao entre as duas abordagens utilizadas, verificando as variaçoes dos objetivos das aulas, da forma de mistura-la e também as diferentes formas de avaliaçao que aconteceram em funçao da idade dos alunos

Boas práticas do estágio supervisionado de Licenciatura em Educação Física

O presente estudo tem como objetivo discutir as atividades realizadas no Estágio Supervisionado em Educaçao Física para o Ensino Fundamental, a fundamentaçao teórica utilizada para montagem das aulas, além de analisar a participaçao e desenvolvimento dos alunos. Portanto sao discutidas as características das abordagens pedagógicas escolhidas (Construtivista e Desenvolvimentista) e a participaçao dos alunos. Foi possível estabelecer uma comparaçao entre as duas abordagens utilizadas, verificando as variaçoes dos objetivos das aulas, da forma de mistura-la e também as diferentes formas de avaliaçao que aconteceram em funçao da idade dos alunos

Ideología y ciencia en la psicología argentina : Las configuraciones de un themata (1958-1975)

Este artículo propone el concepto de themata para analizar la forma en que los criterios científicos y políticos fueron articulados en la psicología argentina de 1958 a 1975. En este período el themata ideología/ciencia fue fundamental en el establecimiento del estatus epistemológico del saber psicológico de la psiquiatría, psicoanálisis y psicología. Dicho themata fue modulado por la filiación marxista de algunos de los principales autores de esas disciplinas. Se analizarán desde el marco de la historia intelectual y de la ciencia las propues- tas epistemológicas de José Bleger, de la psiquiatría comunista pavloviana y de la psicología estructuralista psicoanalítica, a fin de comprender el papel de los valores epistémicos y no epistémicos en la fundamentación de las prácticas psicológicas

Pollen record from Muggesfelder See and Plussee in Germany

A basaltic tephra layer consisting of brownish-olive glass shards. and about 0.2 mm thick. was found in cores from four lakes in northwest Germany. According to pollen analysis it was deposited during the early Boreal period (corresponding to about 8700 BP). The petrographic properties. the geochemical composition and the age agree with those of the Saksunarvatn tephra. which was first found on the Faroe Islands. The position of the tephra layer in the pollen stratigraphy and in the absolute time-scale is discussed. Procedures for locating the tephra in other cores are suggested.

(Supplement 3) Radar sounding observations including bedrock and surface elevation and ice thickness in the ASB region, Antarctica

The first Cenozoic ice sheets initiated in Antarctica from the Gamburtsev Subglacial Mountains and other highlands as a result of rapid global cooling ~34 million years ago. In the subsequent 20 million years, at a time of declining atmospheric carbon dioxide concentrations and an evolving Antarctic circumpolar current, sedimentary sequence interpretation and numerical modelling suggest that cyclical periods of ice-sheet expansion to the continental margin, followed by retreat to the subglacial highlands, occurred up to thirty times. These fluctuations were paced by orbital changes and were a major influence on global sea levels. Ice-sheet models show that the nature of such oscillations is critically dependent on the pattern and extent of Antarctic topographic lowlands. Here we show that the basal topography of the Aurora Subglacial Basin of East Antarctica, at present overlain by 2-4.5 km of ice, is characterized by a series of well-defined topographic channels within a mountain block landscape. The identification of this fjord landscape, based on new data from ice-penetrating radar, provides an improved under¬standing of the topography of the Aurora Subglacial Basin and its surroundings, and reveals a complex surface sculpted by a succession of ice-sheet configurations substantially different from today's. At different stages during its fluctuations, the edge of the East Antarctic Ice Sheet lay pinned along the margins of the Aurora Subglacial Basin, the upland boundaries of which are currently above sea level and the deepest parts of which are more than 1 km below sea level. Although the timing of the channel incision remains uncertain, our results suggest that the fjord landscape was carved by at least two ice- flow regimes of different scales and directions, each of which would have over-deepened existing topographic depressions, reversing valley floor slopes.