PSV for the past 16 ka cal BP from Lake Tangra Yumco, Tibetan Plateau

Paleomagnetic data including inclination, declination, MAD values and MDF are given on an event correct composite depth (ECCD) and age for the composite lacustrine record TAN12-2 from Lake Tangra Yumco, Tibetan Plateau.

Temperature variabilty in the southeastern Black-Sea during 64-20ka BP

The Eurasian inland propagation of temperature anomalies during glacial millennial-scale climate variability is poorly understood but this knowledge is crucial to understanding hemisphere-wide atmospheric teleconnection patterns and climate mechanisms. Based on biomarkers and geochemical paleothermometers, a pronounced continental temperature variability between 64,000 and 20,000 years ago, coinciding with the Greenland Dansgaard-Oeschger cycles, was determined in a well-dated sediment record from the formerly enclosed Black Sea. Cooling during Heinrich events was not stronger than during other stadials in the Black Sea. This is corroborated by modeling results showing that regular Dansgaard-Oeschger cycles penetrated deeper into the Eurasian continent than Heinrich events. The pattern of coastal ice-rafted detritus suggests a strong dependence on the climate background state, with significantly milder winters during periods of reduced Eurasian ice sheets and an intensified meridional atmospheric circulation.

Dinocyst-derived sea-surface characteristics, palynomorph abundances, ice-rafted debris, and planktonic foraminifera abundances and d18O of the 35-41 ka BP interval of core MD99-2285

The last glacial millennial climatic events (i.e. Dansgaard-Oeschger and Heinrich events) constitute outstanding case studies of coupled atmosphere-ocean-cryosphere interactions. Here, we investigate the evolution of sea-surface and subsurface conditions, in terms of temperature, salinity and sea ice cover, at very high-resolution (mean resolution between 55 and 155 years depending on proxies) during the 35-41 ka cal BP interval covering three Dansgaard-Oeschger cycles and including Heinrich event 4, in a new unpublished marine record, i.e. the MD99-2285 core (62.69°N; -3.57s°E). We use a large panel of complementary tools, which notably includes dinocyst-derived sea-ice cover duration quantifications. The high temporal resolution and multiproxy approach of this work allows us to identify the sequence of processes and to assess ocean-cryosphere interactions occurring during these periodic ice-sheet collapse events. Our results evidence a paradoxical hydrological scheme where (i) Greenland interstadials are marked by a homogeneous and cold upper water column, with intensive winter sea ice formation and summer sea ice melting, and (ii) Greenland and Heinrich stadials are characterized by a very warm and low saline surface layer with iceberg calving and reduced sea ice formation, separated by a strong halocline from a less warm and saltier subsurface layer. Our work also suggests that this stadial surface/subsurface warming started before massive iceberg release, in relation with warm Atlantic water advection. These findings thus support the theory that upper ocean warming might have triggered European ice-sheet destabilization. Besides, previous paleoceanographic studies conducted along the Atlantic inflow pathways close to the edge of European ice-sheets suggest that such a feature might have occurred in this whole area. Nonetheless, additional high resolution paleoreconstructions are required to confirm such a regional scheme.

Stable carbon isotope ratios of carbon dioxide from EDC and Berkner Island ice cores for 40-50 ka BP

The stable carbon isotopic signature of carbon dioxide (d13CO2) measured in the air occlusions of polar ice provides important constraints on the carbon cycle in past climates. In order to exploit this information for previous glacial periods, one must use deep, clathrated ice, where the occluded air is preserved not in bubbles but in the form of air hydrates. Therefore, it must be established whether the original atmospheric d13CO2 signature can be reconstructed from clathrated ice. We present a comparative study using coeval bubbly ice from Berkner Island and ice from the bubble-clathrate transformation zone (BCTZ) of EPICA Dome C (EDC). In the EDC samples the gas is partitioned into clathrates and remaining bubbles as shown by erroneously low and scattered CO2 concentration values, presenting a worst-case test for d13CO2 reconstructions. Even so, the reconstructed atmospheric d13CO2 values show only slightly larger scatter. The difference to data from coeval bubbly ice is statistically significant. However, the 0.16 per mil magnitude of the offset is small for practical purposes, especially in light of uncertainty from non-uniform corrections for diffusion related fractionation that could contribute to the discrepancy. Our results are promising for palaeo-atmospheric studies of d13CO2 using a ball mill dry extraction technique below the BCTZ of ice cores, where gas is not subject to fractionation into microfractures and between clathrate and bubble reservoirs.

Diatom isotope data from ODP Hole 178-1098A for the last deglaciation (12.2-12.8 ka BP)

Understanding the response of the Antarctic ice sheets during the rapid climatic change that accompanied the last deglaciation has implications for establishing the susceptibility of these regions to future 21st Century warming. A unique diatom d18O record derived from a high-resolution deglacial seasonally laminated core section off the west Antarctic Peninsula (WAP) is presented here. By extracting and analysing single species samples from individual laminae, season-specific isotope records were separately generated to show changes in glacial discharge to the coastal margin during spring and summer months. As well as documenting significant intra-annual seasonal variability during the deglaciation, with increased discharge occurring in summer relative to spring, further intra-seasonal variations are apparent between individual taxa linked to the environment that individual diatom species live in. Whilst deglacial d18O are typically lower than those for the Holocene, indicating glacial discharge to the core site peaked at this time, inter-annual and inter-seasonal alternations in excess of 3 per mil suggest significant variability in the magnitude of these inputs. These deglacial variations in glacial discharge are considerably greater than those seen in the modern day water column and would have altered both the supply of oceanic warmth to the WAP as well as regional marine/atmospheric interactions. In constraining changes in glacial discharge over the last deglaciation, the records provide a future framework for investigating links between annually resolved records of glacial dynamics and ocean/climate variability along the WAP.

Pier Paolo Pasolini. La ragione de un sogno

Pasolini es poesía. La vida de Pasolini es poesía. Su obra, y especialmente su cine, es poesía. Todo, poesía. Palabra poética. Y teatro de la palabra. De un poeta que sueña un sueño dentro de otro sueño. Y de un poeta que sueña muchos sueños. Por eso sabe qué es verdad. Verdad-mito, porque es realidad. Y realidad-mito, porque es realidad verdadera. Sueño soñado despierto. Y cómo voy a hablar de un poeta que sueña ‘la razón de su sueño’, sin que utilice (prestada) la poesía de sus palabras? Espero poderlo conseguir.

Francisco Oliveira, Paolo Fedeli, Delfim Leão (edd.), O Romance Antigo. Origens de um género Literário, Coimbra, Universidade de Coimbra–Università degli Studi di Bari, 2005, 281 pp. [ISBN 972- 9057-21-4]

Resumo indisponível.

Estudio del libro de apeos y repartimientos de Daimalos de 1572. Conocer el pasado para preservar la memoria y el futuro de nuestros pueblos

En este trabajo en primer lugar se transcribe el libro de apeos y repartimientos de Daimalos. Posteriormente se realiza un pormenorizado estudio socioeconómico de este rico mundo morisco para seguidamente poner en el "mapa" todo aquel patrimonio que se relaciona en dicho documento. Para ello se busca y localiza el patrimonio que se relaciona en el LAR para posteriormente geolocalizar y cartografiar el mismo. Estos aspectos se pueden considerar como "novedosos" en este tipo de trabajos a los que se unen la realización de una serie de propuestas encaminadas a la protección y puesta en valor de este rico patrimonio morisco mediante la redacción de un plan estratégico que englobaría a la mayor parte de la comarca de la Axarquía

Unibo-BP: an innovative free software implementation of Bundle Protocol Version 7 (RFC 9171)

The BP (Bundle Protocol) version 7 has been recently standardized by IETF in RFC 9171, but it is the whole DTN (Delay-/Disruption-Tolerant Networking) architecture, of which BP is the core, that is gaining a renewed interest, thanks to its planned adoption in future space missions. This is obviously positive, but at the same time it seems to make space agencies more interested in deployment than in research, with new BP implementations that may challenge the central role played until now by the historical BP reference implementations, such as ION and DTNME. To make Unibo research on DTN independent of space agency decisions, the development of an internal BP implementation was in order. This is the goal of this thesis, which deals with the design and implementation of Unibo-BP: a novel, research-driven BP implementation, to be released as Free Software. Unibo-BP is fully compliant with RFC 9171, as demonstrated by a series of interoperability tests with ION and DTNME, and presents a few innovations, such as the ability to manage remote DTN nodes by means of the BP itself. Unibo-BP is compatible with pre-existing Unibo implementations of CGR (Contact Graph Routing) and LTP (Licklider Transmission Protocol) thanks to interfaces designed during the thesis. The thesis project also includes an implementation of TCPCLv3 (TCP Convergence Layer version 3, RFC 7242), which can be used as an alternative to LTPCL to connect with proximate nodes, especially in terrestrial networks. Summarizing, Unibo-BP is at the heart of a larger project, Unibo-DTN, which aims to implement the main components of a complete DTN stack (BP, TCPCL, LTP, CGR). Moreover, Unibo-BP is compatible with all DTNsuite applications, thanks to an extension of the Unified API library on which DTNsuite applications are based. The hope is that Unibo-BP and all the ancillary programs developed during this thesis will contribute to the growth of DTN popularity in academia and among space agencies.

Melhoria da Atenção à Saúde das Crianças de 0 a 72 Meses na UBS Agenor Paolo da Silva, Alto Alegre/RR

A atenção à saúde das crianças tem como objetivo garantir um adequado desenvolvimento nesse período da vida a partir de um estudo adequado nas diferentes faixas etárias para conseguir um desenvolvimento e crescimento ótimo, abordando aspectos ambientais, biopsicossociais, promoção a saúde e prevenção de agravos como estratégia fundamental. O acompanhamento das crianças na atenção primária é de fundamental relevância, pois pode atuar de forma preventiva na diminuição das taxas de mortalidade infantil com a garantia de um acompanhamento de qualidade. Objetivando qualificar a atenção das crianças pertencentes à Unidade de Saúde Agenor Paolo da Silva do município de Alto Alegre/RR foi realizada uma intervenção em saúde entre os meses de fevereiro e junho de 2015 direcionada à população anteriormente citada. Inicialmente, foi organizado um projeto com os seguintes objetivos: ampliar a cobertura, melhorar a adesão e qualidade dos atendimentos às crianças, melhorar o registro das informações, mapear as crianças de risco e promover saúde. A relevância da intervenção encontra-se na garantia da saúde por meio de um acompanhamento efetivo e humanizado incluindo ações de prevenção e promoção à saúde, além de diagnóstico e tratamento precoce das patologias que podem ocorrer nesse período. Para alcançar os objetivos foram realizadas ações nos quatro eixos pedagógicos do curso, a saber: monitoramento e avaliação, organização e gestão do serviço, engajamento público e qualificação da prática clínica. Utilizamos a Planilha de coleta de dados e ficha espelho disponibilizada pela Universidade Federal de Pelotas. Antes da intervenção, das 162 crianças estimadas para a área, a equipe acompanhava 6% (11) das crianças menores de 1 ano. Diante disso, a equipe propôs a intervenção para realizar uma ampliação e qualificação da atenção a saúde das crianças. Desta forma, após a intervenção alcançamos como principais resultados o acompanhamento na puericultura de 79 crianças até 72 meses (48%) estimadas para a área. A maioria dos indicadores de qualidade foi alcançada em sua totalidade, tais como, monitoramento de crianças com excesso de peso, monitoramento do desenvolvimento, realização do teste do pezinho e triagem auditiva. Os resultados que não tiveram êxito foram vacinação em dia para 73 crianças (92,4%), suplementação de ferro para 20 crianças (87%) e primeira consulta odontológica para 55 crianças (77,5%). As ações desenvolvidas na unidade durante a intervenção podem ser consideradas como ações simples, mas de grande relevância para a qualificação da assistência as crianças, pois contribuíram para a melhoria dos atendimentos dispensados.

Mucopolysaccharidosis Type Ii: Identification Of 30 Novel Mutations Among Latin American Patients.

In this study, 103 unrelated South-American patients with mucopolysaccharidosis type II (MPS II) were investigated aiming at the identification of iduronate-2-sulfatase (IDS) disease causing mutations and the possibility of some insights on the genotype-phenotype correlation The strategy used for genotyping involved the identification of the previously reported inversion/disruption of the IDS gene by PCR and screening for other mutations by PCR/SSCP. The exons with altered mobility on SSCP were sequenced, as well as all the exons of patients with no SSCP alteration. By using this strategy, we were able to find the pathogenic mutation in all patients. Alterations such as inversion/disruption and partial/total deletions of the IDS gene were found in 20/103 (19%) patients. Small insertions/deletions/indels (<22 bp) and point mutations were identified in 83/103 (88%) patients, including 30 novel mutations; except for a higher frequency of small duplications in relation to small deletions, the frequencies of major and minor alterations found in our sample are in accordance with those described in the literature.

Nanomolar Levels Of Pahs In Extracts From Urban Air Induce Mapk Signaling In Hepg2 Cells.

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that occur naturally in complex mixtures. Many of the adverse health effects of PAHs including cancer are linked to the activation of intracellular stress response signaling. This study has investigated intracellular MAPK signaling in response to PAHs in extracts from urban air collected in Stockholm, Sweden and Limeira, Brazil, in comparison to BP in HepG2 cells. Nanomolar concentrations of PAHs in the extracts induced activation of MEK4 signaling with down-stream increased gene expression of several important stress response mediators. Involvement of the MEK4/JNK pathway was confirmed using siRNA and an inhibitor of JNK signaling resulting in significantly reduced MAPK signaling transactivated by the AP-1 transcription factors ATF2 and c-Jun. ATF2 was also identified as a sensitive stress responsive protein with activation observed at extract concentrations equivalent to 0.1 nM BP. We show that exposure to low levels of environmental PAH mixtures more strongly activates these signaling pathways compared to BP alone suggesting effects due to interactions. Taken together, this is the first study showing the involvement of MEK4/JNK/AP-1 pathway in regulating the intracellular stress response after exposure to nanomolar levels of PAHs in environmental mixtures.