Introdução ao estudo – Determinantes da fecundidade em Portugal

Portugal regista atualmente um dos mais baixos níveis de fecundidade da Europa e do mundo, resultado da redução do número de filhos e do adiamento dos nascimentos para idades mais tardias. As características individuais e a idade ao nascimento do primeiro filho são determinantes cruciais para o número de filhos que se tem e que se espera ter, variando em função do grau de instrução. Apesar das alterações comportamentais ao longo das últimas décadas, os contextos familiares e a conjugalidade continuam a ser centrais na vida dos portugueses, pois aqueles que não vivem com cônjuge ou companheiro apresentam fecundidades mais baixas. A dimensão familiar ideal é outro determinante crítico, dado que ideais mais baixos potenciam que se tenha menos filhos, dificultando a recuperação da fecundidade. O ideal parece corresponder ao número de filhos que permite manter um determinado nível de vida para a família e ainda garantir aos filhos mais oportunidades, mesmo que para tal se tenha apenas um filho. Daí também a atual relevância das questões económicas nas decisões de fecundidade. A alteração de mentalidades parece ter gerado um novo modelo social marcado por uma crescente valorização dos filhos.

O género sonata em Portugal: subsídios para o estudo do repertório português para tecla de 1750 a 1807

O repertório português para instrumentos de tecla da segunda metade do século XVIII encontra-se disperso em bibliotecas e arquivos, em Portugal e no estrangeiro, essencialmente sob a forma de manuscrito. Neste repertório, a sonata emerge como um género musical de grande importância. De facto, as duas coleções de sonatas publicadas na época constituem as únicas obras para instrumentos de tecla impressas em Portugal durante todo esse século. O objetivo deste trabalho é realizar um inventário do repertório português composto para instrumentos de tecla durante o período acima descrito, focando a respectiva descrição formal e as características composicionais das sonatas em geral, e na produção de cada compositor português em particular, bem como as suas biografias e perfis. De forma a estudar a sonata portuguesa e o seu desenvolvimento no período compreendido entre 1750–1807, foi realizado um levantamento das obras portuguesas existentes para instrumentos de tecla deste período. Este levantamento foi acompanhado por pesquisas biográficas sobre cada compositor e por uma abordagem analítica baseada na Teoria da Sonata de James Hepokoski e Warren Darcy. A divisão deste período em dois subperíodos demonstra variações significativas na evolução da sonata portuguesa. O estudo deste repertório demonstra que a sonata é o género musical predominante e define o modelo da sonata portuguesa deste período, para além de caracterizar o desenvolvimento da sonata em Portugal em paralelo com o desenvolvimento deste género musical em Itália e Espanha; ABSTRACT: The Sonata Genre in Portugal: Contributions for the Study of the Portuguese Keyboard Repertory from 1750 to 1807 The extant Portuguese repertory of the second half of the eighteenth century for keyboard instruments is dispersed in libraries and archives, in Portugal and abroad, mainly in manuscript form. In that repertory, the sonata emerges as a genre of great importance. Indeed, the two collections of sonatas published at the time are the only works for keyboard instruments printed in Portugal throughout the entire century. The aim of the present work is to make an inventory of the Portuguese repertory written for keyboard instruments during the above-mentioned period, with a focus on its formal description and the compositional characteristics of the sonatas in general and in the production of each Portuguese composer in particular, in addition to the biographies and profiles of the latter. In order to study the Portuguese sonata and its development in the period comprised between 1750–1807, a survey of the existing Portuguese works for keyboard instruments from that period was done. This survey was followed by a research on the biography of each composer and an analytic approach based on the Sonata Theory by James Hepokoski and Warren Darcy. Dividing this period in two sub periods showed significant variations on the evolution of the Portuguese sonata. The study of this repertory shows that the sonata is the predominant musical genre within it and identifies the Portuguese sonata model of this period, besides characterizing the development of the sonata in Portugal in parallel with the development of the same genre in Italy and Spain.

Estudo e análise técnica e interpretativa do papel principal de tenor nas óperas Lucia di Lammermoor (Edgardo) e L' Elisir d' Amore (Nemorino) de Gaetano Donizetti

Nesta dissertação pretendemos analisar a interpretação do papel do tenor nas óperas Lucia di Lammermoor e L´Elisir d´Amore de Gaetano Donizetti, estudando os principais fatores que influenciaram a interpretação do papel do tenor e como esta mudou ao longo dos anos, por comparação de gravações destas óperas com 50 anos de intervalo entre si. O período do bel canto está associado à linha de canto ornamentada para exprimir emoções, o que, em conjunto com outros aspetos, fez com que a voz de tenor passasse a ter uma emissão distinta, especialmente no registo agudo. O contexto histórico e musical desta época, bem como os desenvolvimentos técnicos que se verificaram, influenciaram a forma de cantar e introduziram o tenor como papel principal nas óperas, com todos os desafios de cantar na zona de passagem, de domínio da respiração e de respeito pelas diversas formas de expressão musical que os compositores do período do bel canto usavam como veículos de interpretação e expressão dos sentimentos. A escolha destas duas óperas de Donizetti assenta num gosto pessoal e no meu interesse em estudar os contrastes dos personagens Edgardo e Nemorino, que são apresentados nesta dissertação sob o ponto de vista interpretativo, analisando a problemática de cada papel e a forma como o percurso tonal destas obras influencia as performances dos intérpretes; Abstract: STUDY AND ANALYSIS TECHNICAL-INTERPRETATION OF THE LEADING ROLE OF THE TENOR IN THE OPERAS LUCIA DI LAMMERMOOR (EDGARDO) AND L´ELISIR D´AMORE (NEMORINO) OF GAETANO DONIZETTI In this dissertation we analyze the interpretation of the tenor role in the operas Lucia di Lammermoor and L´Elisir d´Amore by Gaetano Donizetti, studying the major factors that influenced the tenor role interpretation and how it developed along the years, by comparing two recordings of these operas recorded 50 years apart from each other. The period of the bel canto is associated with the vocal ornamentation to express emotions which, as a consequence and together with other aspects, required technical changes to the tenor voice, in particular the high register. The historic and musical context of this time, as well as the technical developments that happened then, influenced the way of singing and introduced the tenor as the main role in operas, with all the challenges to sing in the passagio, to master the breathing process and to use all the forms of musical expression that the bel canto composers used as vehicles to interpret and express feelings. The choice of these two operas by Donizetti is based on personal taste and also on the interpretative contrasts between the roles of Edgardo and Nemorino, studied in this dissertation in terms of their interpretation, their problematic and how the harmony of these operas influences the interpretation of the singers.

Relatório da prática de ensino supervisionada realizada no Conservatório Regional de Évora: abandono do estudo da guitarra no final do 3.º ciclo: principais fatores

Resumo I (Prática de Ensino Supervisionada) O presente relatório tem como objetivo dar a conhecer o trabalho pedagógico realizado no Conservatório regional de Évora Eborae Mvsica, no âmbito do Mestrado em Ensino da Universidade de Évora, no qual serão abordados diversos temas: caracterização da escola e do meio envolvente, aulas assistidas e aulas lecionadas, metas de aprendizagem, tipos de avaliação, repertórios, finalizando com uma conclusão que espelha as várias reflexões sobre a prática letiva. Resumo II (Investigação) A Investigação apresenta inicialmente uma contextualização e definição dos agentes envolvidos no processo ensino-aprendizagem bem como a sua devida caracterização. Na investigação propriamente dita, são descritas as várias etapas do projeto de investigação, dentro de um determinado contexto, expondo igualmente várias abordagens e fatores que possam contextualizar o abandono da aprendizagem de guitarra no final do 3.º ciclo e as consequentes ilações. Como possível solução para esta problemática, elaborei um modeloguia para o professor; Abstract I (Teaching) The following report aims to let know the pedagogical work carried out at the regional conservatory of Évora Eborae Mvsica within the Master in Teaching at the University of Évora, in which various topics will be addressed: characterization of the school and the surrounding environment, assisted lessons and lessons taught, learning goals, types of evaluation, repertoires, ending with a conclusion that considerate the various reflections on teaching practice . Abstract II (Research) The investigation presents, initially, a context and definition of the agents involved in the teaching-learning process and their proper characterization. In the investigation itself, the various stages are described of the research project, within a given context, also exposing various approaches and factors that may contextualize the guitar learning abandonment at the end of the 3rd cycle and the resulting conclusions. As a possible solution to this problem, I prepared a guide model for the teacher.

Estudo vídeo-polissonográfico em recém-nascidos de termo pequenos para a idade gestacional

Video-polygraphic-EEG studies were performed in the first 24 life-hours of 26 healthy full-term newborns without perinatal injuries. The neurological examination and cranial ultrasonography were normal. The newborns were divided into two groups: one, with full-term appropriate - birth weight 11 newborns (control group ) and the other with full-term low-birth weight 15 newborns. Thirteen newborns of the second group had video-polygraphic-EEG study abnormalities. The most frequent abnormalities were found in 11 cases, as far as sleep architecture is concerned. Also, when compared with the control group, 8 cases of an excessive amount of startles and 2 cases of low behavior activities were found. The results demonstrate the usefulness of video-polygraphic-EEG study in the full-term newborns with intra-uterine growth retard. This examination was sensitive to detect behavior, sleep architecture and EEG standard differences in the low birth-weight newborns as to the control group.

Síndrome de Rett: estudo retrospectivo e prospectivo de 28 pacientes

From November 1982 to May 1999, 28 children with Rett syndrome were followed-up for a medium period of 6 years and 2 months. Regression of developmental milestones started at the age between 5 and 20 months. Nineteen cases of typical Rett syndrome had uneventful pre and perinatal periods, loss of previously acquired purposeful hand skills, mental and motor regression and developed hand stereotypies; sixteen had head growth deceleration and 12 gait apraxia. Nine patients were atypical cases, 2 formes frustres, 2 congenital, 3 with early seizure onset, 1 preserved speech and 1 male. Epilepsy was present in 21 patients, predominantly partial seizures and the drug of choise was carbamazepine (15 patients). In the initial evaluation most patients were distributed on Stages II and III and on follow-up on Stages III and IV. Three children died.

Síndrome de Down e Moyamoya: estudo através de metanálise

We present a clinic-epidemiological study of two patients and meta-analysis (period 1977-2000 ) of the co-morbidity of the Down syndrome (DS) and moyamoya syndrome (MMS). Among the 42 patients listed in this survey, meta-analysis permitted to find the highest number of publications by researchers from Japan and United States, followed by Brazil and Italy; prevalence of cerebrovascular disease in suckling and pre school children; first symptomatology was hemiparesis (78.6%), speech disorders (26.2%); ischemic infarction (76.2%); recurring ischemic episodes (62%); bilateral impairment (83.3%). This analysis led to the conclusion that in the clinic-neurological investigation of DS patients with acute hemiparesis episodes, MMS should be included as the most probable diagnosis.

Estudo teórico da interação existente entre a artemisinina e o heme

The purpose of this work is to study theoretically stereoelectronic aspects of the interaction between heme and artemisinin in the transitional heme-artemisinin complex. Through semi-empirical calculations using the PM3 method, the potential energy barrier of artemisinin rotation relative to heme in the heme-artemisinin complex was studied in vacuum and in the partially solvated state. The minimum heat of formation obtained for the complex with and without water molecules is -702.39 and -100.86 kcal mol-1, respectively, which corresponds to the dihedral angle C-Fe-O1-O2 of 43.93º and 51.90º around the iron-oxygen O1 bond, respectively. The water molecules bind to heme via 13 hydrogen bonds and O-H O and 6 C-H O interactions, which accounts for -67.23 kcal mol-1. It is observed that the inclusion of water molecules does not affect significantly the stability of the heme-artemisinin complex.

Espectroscopia de Ressonância Magnética Nuclear de 13C no estudo de rotas biossintéticas de produtos naturais

During the last five decades, as a result of an interaction between natural product chemistry, synthetic organic chemistry, molecular biology and spectroscopy, scientists reached an extraordinary level of comprehension about the natural processes by which living organisms build up complex molecules. In this context, 13C nuclear magnetic resonance spectroscopy, allied with isotopic labeling, played a determinant role. Nowadays, the widespread use of modern NMR techniques allows an even more detailed picture of the biochemical steps by accurate manipulation of the atomic nuclei. This article focuses on the development of such techniques and their impact on biosynthetic studies.

Estudo da capacidade de complexação e sua relação com algumas variáveis ambientais em cinco represas do Rio Tietê/Brasil

The copper and cadmium complexation properties in natural sediment suspensions of reservoirs of the Tietê River were studied using the solid membrane copper and cadmium ion-selective electrodes. The complexation and the average conditional stability constants were determined under equilibrium conditions at pH=6.00 ± 0.05 in a medium of 1.0 mol L-1 sodium nitrate, using the Scatchard method. The copper and cadmium electrodes presented Nernstian behavior from 1x10-6 to 1x10-3 mol L-1 of total metal concentration. Scatchard graphs suggest two classes of binding sites for both metals. A multivariate study was done to correlate the reservoirs and the variables: complexation properties, size, total organic carbon, volatile acid sulfide, E II and pH.

Efeito das interações hiperconjugativas na constante de acoplamento ¹J CH da hexametilenotetramina e do adamantano: estudo teórico e experimental

The objective of this work was to determine the influence of hyperconjugative interactions on the ¹J CH coupling constant for hexamethylenetetramine (1) and adamantane (2). For this end, theoretical and experimental ¹J CH were obtained and hyperconjugative interactions were investigated using NBO. It was observed, theoretically and experimentally, that ¹J CH in 1 is 20 Hz larger than in 2, mainly due to the nN®s*C-H hyperconjugative interaction. This interaction occurs only in 1, with an energy of 9.30 kcal mol-1. It increases the s-character of the carbon atom in the C-H bond and the occupancy of the sigma*C-H orbital in (1).

Síntese e estudo de ortossilicatos de zinco luminescentes com aplicação da técnica sol-gel

Usually, the concepts of the Sol-Gel technique are not applied in experimental chemistry courses. This work presents a feasible experiment for chemistry instruction, which involves the synthesis of luminescent materials - Zn2SiO4, with and without Mn2+ as a dopant - by the Sol-Gel technique. The obtained materials were analyzed by scanning electron microscopy, X-Ray diffraction, IR spectroscopy and luminescence measures by UV-vis spectroscopy. The results allow the students to confirm the luminescent properties of the zinc orthosilicate luminophores as well as the structural features expected from literature data.

Estudo por espectroscopia micro-Raman dos mecanismos de separação de fase em vidros fosfatos de metais de transição

Glass-ceramics are prepared by controlled separation of crystal phases in glasses, leading to uniform and dense grain structures. On the other hand, chemical leaching of soluble crystal phases yields porous glass-ceramics with important applications. Here, glass/ceramic interfaces of niobo-, vanado- and titano-phosphate glasses were studied by micro-Raman spectroscopy, whose spatial resolution revealed the multiphase structures. Phase-separation mechanisms were also determined by this technique, revealing that interface composition remained unchanged as the crystallization front advanced for niobo- and vanadophosphate glasses (interface-controlled crystallization). For titanophosphate glasses, phase composition changed continuously with time up to the equilibrium composition, indicating a spinodal-type phase separation.

Aplicações de cromatografia líquida de alta eficiência para o estudo de poluentes orgânicos emergentes

Emerging organic pollutants (EOP) include many environmental contaminants based on commercial products such as pharmaceuticals, personal care products, detergents, gasoline, polymers, etc. EOP may be candidates for future regulation as they offer potential risk to environmental and human health due to their continual entrance into the environment and to the fact that even the most modern wastewater treatment plants are not able to totally transform / remove these compounds. High performance liquid chromatography is recommended to separate emerging organic pollutants with characteristics of high polarity and low volatility, especially pharmaceuticals, from environmental matrices.

Estudo químico de Sinningia allagophylla guiado por testes de atividade antiproliferativa

Activity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extract, fractions, and compounds lapachenol, 8-methoxylapachenol, and dunniol were tested in vitro against human cancer cell lines U251 (glioma, CNS), MCF-7 (breast), NCI-ADR/RES (drug-resistant ovarian), 786-0 (kidney), NCI-H460 (lung, no small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon), K562 (leukemia) and against VERO, a normal cell line. The most active compound was dunniol, which inhibited the growth of U251, MCF-7, NCI-ADR/RES, OVCAR-3 and K562 cell lines.