Quarta pars huius operis in se continens glosam ordinaria[m] cum expositione lyre litterali et morali : necnon additionibus ac replicis : super libros, Esaie, Hieremie, Threnorum, Baruch, Ezechielis, Danielis, Osee, Amos, Abdie, Ione, Michee, Naum, Abacuk

Pie de imp. tomado del colofón de la sexta parte

Quinta pars huius operis in se contine[n]s glosam ordinariam cu[m] expositio[n]e lyre litterali [et] morali : necnon additionibus ac replicis : super libros, Matthei, Marci, Luce, Ioha[n]nis.

Pie de imp. tomado del colofón de la sexta parte

Quinta pars huius operis in se contine[n]s glosam ordinariam cu[m] expositio[n]e lyre litterali [et] morali : necnon additionibus ac replicis : super libros, Matthei, Marci, Luce, Ioha[n]nis.

Pie de imp. tomado del colofón de la sexta parte

Sexta pars biblie cu[m] glosa ordinaria [et] expositio[n]e lyre litterali [et] morali : necno[n] additio[n]ib[us] ac replicis : sup[er] Ep[istol]as ad Romanos, Corinthios, Galathas, Ephesios, Philippenses, Colossenses, Thessalonicenses, Timotheum, Titum,

Capitulares miniadas

Sermones sancti Vincentij fratris ordinis predicatorum de tempore, Pars hiemalis ; De sanctis

Datos de impresor tomados del IBE

Sermones sancti Vincentij fratris ordinis predicatorum de tempore . Pars estivalis

Datos de impresor tomados del IBE

De proprietate latini sermonis. Festo: De verborum significatione. Terencio Varron: De lingua latina ; Analogia

Sign.: a4, b-i6, k4, l-r6, s3

Biblia latina

Pie de imp. tomado de colofón

Caii Plinii Secundi nouocomensis oratoris facundissimi epistolarum ...

Pie de imp. tomado de colofón

Fasciculus temporum, vel Chronica ab initio mundi.

Colofón en h. 65

Apianus Alexandrinus De bellis ciuilibus ... [P. Candidi ... in latinum traductis]

Sign.: a8, b-z6, [et]6, [cum]6, [rum]6, A6, B-C8

Josephus de Antiquitatibus ac de bello Judaico

Mención de traductor tomado inicio de texto en h. 1

Supplementum chronicarum

Mención de resp. tomado de inicio texto en h. [2]

DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data

Background DCE@urLAB is a software application for analysis of dynamic contrast-enhanced magnetic resonance imaging data (DCE-MRI). The tool incorporates a friendly graphical user interface (GUI) to interactively select and analyze a region of interest (ROI) within the image set, taking into account the tissue concentration of the contrast agent (CA) and its effect on pixel intensity. Results Pixel-wise model-based quantitative parameters are estimated by fitting DCE-MRI data to several pharmacokinetic models using the Levenberg-Marquardt algorithm (LMA). DCE@urLAB also includes the semi-quantitative parametric and heuristic analysis approaches commonly used in practice. This software application has been programmed in the Interactive Data Language (IDL) and tested both with publicly available simulated data and preclinical studies from tumor-bearing mouse brains. Conclusions A user-friendly solution for applying pharmacokinetic and non-quantitative analysis DCE-MRI in preclinical studies has been implemented and tested. The proposed tool has been specially designed for easy selection of multi-pixel ROIs. A public release of DCE@urLAB, together with the open source code and sample datasets, is available at http://www.die.upm.es/im/archives/DCEurLAB/ webcite.

Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol

Scavenger receptor BI (SR-BI) is a cell surface receptor that binds high density lipoproteins (HDL) and mediates selective uptake of HDL cholesteryl esters (CE) in transfected cells. To address the physiological role of SR-BI in HDL cholesterol homeostasis, mice were generated bearing an SR-BI promoter mutation that resulted in decreased expression of the receptor in homozygous mutant (designated SR-BI att) mice. Hepatic expression of the receptor was reduced by 53% with a corresponding increase in total plasma cholesterol levels of 50–70% in SR-BI att mice, attributable almost exclusively to elevated plasma HDL. In addition to increased HDL-CE, HDL phospholipids and apo A-1 levels were elevated, and there was an increase in HDL particle size in mutant mice. Metabolic studies using HDL bearing nondegradable radiolabels in both the protein and lipid components demonstrated that reducing hepatic SR-BI expression by half was associated with a decrease of 47% in selective uptake of CE by the liver, and a corresponding reduction of 53% in selective removal of HDL-CE from plasma. Taken together, these findings strongly support a pivotal role for hepatic SR-BI expression in regulating plasma HDL levels and indicate that SR-BI is the major molecule mediating selective CE uptake by the liver. The inverse correlation between plasma HDL levels and atherosclerosis further suggests that SR-BI may influence the development of coronary artery disease.