Silenciamento epigenético dos genes CRABP2 e MX1 em tumores de cabeça e pescoço

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência do triptofano, da fluoxetina e da paraclorofenilalanina no desenvolvimento inicial e na sobrevivência de larvas de matrinxã

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Feeding adult of Artemia salina (Crustacea-Branchiopoda) on the dinoflagellate Gyrodinium corsicum (Gymnodiniales) and the Chryptophyta Rhodomonas baltica

Experimentos foram desenvolvidos para estudar as taxas de alimentação e de sobrevivência de Artemia salina alimentada com cepas não tóxicas do dinoflagelado Gyrodinium corsicum e da Chryptophyta Rhodomonas baltica. As taxas de filtração sobre R. baltica e G. corsicum variaram entre 3,35 e 7,14 ml.artemia-1.h-1 e 2,97 e 15,86 ml.artemia-1.h-, respectivamente. As taxas de ingestão observadas para A. salina não indicaram disfunção digestiva ou prejuízo fisiológico nos organismos alimentados com G. corsicum, sendo a resposta funcional destes organismos similar a observada em copépodos alimentados com diferentes concentrações de alimento. As taxas de mortalidade de A. salina oscilaram entre 2,5 e 100% quando alimentada com R. baltica e G. corsicum, respectivamente. As maiores taxas de mortalidade observadas para os organismos alimentados com G. corsicum indicam que este dinoflagelado apresenta algum efeito nocivo sobre A. salina, embora não tenha sido possível confirmar se sua origem está relacionada com a produção de toxinas ou com a inadequação nutritiva deste dinoflagelado para alimentação de organismos desta espécie.

Paclobutrazol no crescimento e desenvolvimento in vitro e na aclimatização de Sophronitis cernua (Lindl.) Lindl. e Brassavola flagellaris Barb. Rodr. (Orchidaceae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Paclobutrazol no crescimento e desenvolvimento de Zygopetalum crinitum Lodd. e Cattleya schilleriana Rchb.f. (Orchidaceae) durante as fases in vitro e de aclimatização

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Comportamento de fratura sob carga estática e cíclica das cerâmicas odontológicas quando unidas a um substrato análogo à dentina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Expressão de microRNAs cardíacos induzida por treinamento físico durante insuficiência cardíaca

Pós-graduação em Biologia Geral e Aplicada - IBB

Epidemiological features of esophageal cancer. Squamous cell carcinoma versus adenocarcinoma

PURPOSE: To analyze the epidemiological features of patients with esophageal cancer according to the histopathological types: squamous cell carcinoma or adenocarcinoma. METHODS: A total of 100 patients with esophageal cancer, being 50 squamous cell carcinomas and 50 adenocarcinomas were analyzed for demographics, nutritional factors, lifestyle habits, benign pathological conditions associated, like Barrett's esophagus and megaesophagus, tumor stage and survival rates. The nutritional factors evaluated included body mass index, percent weight loss, hemoglobin and albumin serum levels. RESULTS: Esophageal cancer occurred more often in men over 50 years-old in both histological groups. No significant differences on age and gender were found between the histological groups. Squamous cell carcinoma was significantly more frequent in blacks than adenocarcinoma. Alcohol consumption and smoking were significantly associated with squamous cell carcinoma. Higher values of body mass index were seen in patients with adenocarcinoma. Barrett's esophagus was found in nine patients (18%) with adenocarcinoma, and megaesophagus in two patients (4%) with squamous cell carcinoma. The majority of patients were on stages III and IV in both histological groups. The mean survival rates were 7.7 ± 9.5 months for patients with squamous cell carcinoma and 8.0 ± 10.9 months for patients with adenocarcinoma. No significant differences on tumor stage and survival rates were detected between the histological groups. CONCLUSION: Epidemiological features are distinct for the histopathological types of esophageal cancer. Squamous cell carcinoma is associated with black race, alcohol and smoking, while adenocarcinoma is related to higher body mass index, white race and Barrett's esophagus.

Desempenho produtivo e respostas fisiopatológicas de tambaquis alimentados com ração suplementada com β-glucano

O objetivo deste trabalho foi avaliar o efeito do imunoestimulante β-glucano na dieta do tambaqui (Colossoma macropomum) sobre o desempenho produtivo, as respostas fisiológicas e imunológicas, e a resistência ao desafio com Aeromonas hydrophila. O experimento foi conduzido em delineamento inteiramente casualizado, em arranjo fatorial 5x2, com cinco níveis de β-glucano na dieta (0, 0,1, 0,2, 0,4 e 0,8%) e dois tempos de amostragem (antes e após o desafio com A. hydrophila), com três repetições. Os peixes (28,65±0,49 g; 12,14±0,07 cm) foram alimentados, por 60 dias, com dieta (28% de proteína bruta) suplementada com preparação comercial de β-glucano. Após o período de alimentação, avaliou-se o desempenho produtivo, e os peixes foram desafiados com A. hydrophila. Os parâmetros hematológicos e imunológicos (concentração e atividade de lisozima) foram avaliados antes e após o desafio bacteriano. Após o desafio bacteriano, observouse a ocorrência de anemia normocítica-normocrômica. A suplementação com β-glucano não alterou a concentração nem a atividade da lisozima; porém, a menor concentração de β-glucano (0,1%) favoreceu maior sobrevivência para a espécie quando desafiada com Aeromonas hydrophila. A suplementação de β-glucano não exerce influência sobre o desempenho produtivo e nem sobre os parâmetros hematológicos do tambaqui.

Development of pachycoris torridus (hemiptera: scutelleridae) on jatropha curcas (euphorbiaceae), psidium cattleianum (myrtaceae) and aleurites fordii (euphorbiaceae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Dental anomalies in children submitted to antineoplastic therapy

Cancer is the third most frequent cause of death in children in Brazil. Early diagnosis and medical advances have significantly improved treatment outcomes, which has resulted in higher survival rates and the management of late side effects has become increasingly important in caring for these patients. Dental abnormalities are commonly observed as late effects of antineoplastic therapy in the oral cavity. The incidence and severity of the dental abnormalities depend on the child's age at diagnosis and the type of chemotherapeutic agent used, as well as the irradiation dose and area. The treatment duration and aggressivity should also be considered. Disturbances in dental development are characterized by changes in shape, number and root development. Enamel anomalies, such as discoloration, opacities and hypoplasia are also observed in these patients. When severe, these abnormalities can cause functional and esthetic sequelae that have an impact on the children's and adolescents' quality of life. General dentists and pediatric dentists should understand these dental abnormalities and how to identify them aiming for early diagnosis and appropriate treatment.

Implants in the zygomatic bone for maxillary prosthetic rehabilitation: a systematic review

The purpose of this systematic review was to evaluate clinical studies on the follow-up survival of implants inserted in the zygomatic bone for maxillary rehabilitation. A comprehensive search of studies published from 2000 to July 2012 and listed in the PubMed/MEDLINE, Embase, and Cochrane Library databases was performed in accordance with the PRISMA statement. Relevant studies were selected according to predetermined inclusion and exclusion criteria. The initial database search yielded 751 titles. After filtering, 313 abstracts were selected, culminating in 42 full text articles. Application of eligibility criteria led to the elimination of 17 articles. Hence 25 full-text articles were considered clinically relevant and were included. Calculations of the interval survival rates and cumulative survival rates of implants could be carried out on the data extracted from the final list of included studies for the different time intervals. These studies reported the insertion of a total of 1541 zygomatic implants and 33 implant failures. Failure generally occurred during the first year interval and was related to clinical complications, such as recurrent acute and chronic sinusitis. After a 36-month follow-up, the survival rate was 97.86%. Additional studies with longer follow-up periods, including the number of zygomatic implants inserted and details of the variations in the surgical techniques used and the impact of the maxillary morphology are still required.

Chilling curves for Piaractus mesopotamicus (Holmberg, 1887) embryos stored at-8 degrees C

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Increased brood viability and longer lifespan of honeybees selected for propolis production

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Critérios para indicação de espécies prioritárias para a restauração da vegetação de cerrado

Knowing the attributes of the most suitable species to overcome the obstacles in different environmental conditions is an important tool for ecological restoration. To evaluate the comparative performance of native Cerrado species being cultivated at an arboretum (Assis State Forest, Assis, SP, Brazil), we categorized 106 species by the following attributes: average annual increment in height and crown diameter, survival rates, frequency of herbivory, frost susceptibility and seed dispersal syndrome. The score of each attribute may vary from 1 to 3, and the value of a species for restoration was generated from the sum of the scores for the different attributes converted to the scale of 0 to 100. Analyzing the species altogether, survival was 70%, the average annual increment was 30 cm in height and 21 cm in crown diameter. Only 8% of the species showed high susceptibility to frost and 17% high frequency of herbivory. Eighteen species had scores above 80, being the first Annona crassiflora, Cecropia pachystachya, Enterolobium gummiferum, Plathymenia reticulata e Protium heptaphyllum. In this group are the species that gather the highest number of favorable attributes for the restoration of Cerrado vegetation. We generated two separate lists of ten species of higher value, one for the cerrado sensu stricto and the other for cerradao the forest type of cerrado vegetation. We believe that using these species accelerates the recovery of vegetation structure and thus provide the restoration of ecological processes of ecosystems undergoing restoration. At the end of the list are species of low scores, which, if used, can lead to higher costs or delay in the recovery of structure and ecological processes of the ecosystem being restored.