935 resultados para INTERAÇÕES NUCLEARES


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As pessoas com deficiências são excluídas da sociedade devido à marca negativa de descrédito recebida pelo meio social - por sua aparência ou seu modo de ser diferentes - que os coloca fora da norma classificando-os como seres desviantes. No cotidiano escolar essas marcas se afirmam e se reproduzem, não promovendo às pessoas com deficiências uma superação desse estigma. A pesquisa visa analisar como o estigma incorporado pelos alunos com deficiências influencia no processo de interação e inclusão escolar, de forma a estudar indícios de como se desenvolve o processo de estigmatização no cotidiano escolar sob a luz dos pensamentos de Erving Goffman. O presente estudo utiliza-se uma revisão de literatura especifica do tema, fundamentada nos estudos de Erving Goffman, conjuntamente à pesquisa empírica baseada na etnografia vivenciada pelo autor em seus estudos de comunidade, foram utilizadas como estratégias de pesquisa, entrevistas com três professores e observações registradas por meio de de observação de cenas do cotidiano escolar de ´duas escolas públicas do estado de SPSão Paulo . No capítulo 1 buscamos entender os constructos de Goffman principalmente por meio de sua trajetória acadêmica, no capítulo 2 o trabalho centrou-se na compreensão da interação social e principalmente na questão definida pelo autor como ordem da interação, em queentende-se que as pessoas são autores dentro de um palco social, no capítulo 3. a pesquisa aborda o termo estigma e explica sua influência na interação e no avanço das pessoas com deficiência. Por fim, o trabalho se encerra no capítulo .4 apresentando a análise das entrevistas e dos registros das cenas do cotidiano escolar. As cenas selecionadas apresentam os atores envolvidos, o cenário, e o enredo das interações, identificando as estratégias do estigma incorporado pelos alunos com deficiência e buscando ligações com as políticas inclusivas e as escolas brasileira. A pesquisa identificou que a escola, como meio de socialização e criação de saberes, possui um papel importante neste processo de mudança, apesar de muitas vezes reproduzir o estigma social. Observamos então que a escola pode auxiliar na mudança do olhar que exclui, à maneira que mostra algumas máscaras do social e da própria inclusão; no entanto é importante salientar que sua renovação e de seus agentes sociais deve valorizar as diferenças para construção de novos conhecimentos.(AU)

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Dengue virus is an important patogen that causes Dengue desease in all world, and belongs to Flavivirus gender. The virus consists of enveloped RNA with a single strand positive sense, 11Kb genome. The RNA is translated into a polyprotein precursor, wich is cleaved into 3 structural proteins (C, prM e E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B e NS5). The NS3 is a multifunctional protein, that besides to promote the polyprotein precursor cleavage, also have NTPase, helicase and RTPase activity. The NS3 needs a hydrophilic segment of 40 residues from the transmembrane NS2B protein (who acts like cofator) to realize this functions. Actually, there's no vacines available on the market, and the treatment are just symptomatic. The tetrapeptide inhibitor Bz-Nle-Lys-Arg-Arg-H (Ki de 5,8-7,0 M) was showed as a potent inhibitor μ for NS3prot in Dengue virus. That is a inteligent alternative to treat the dengue desease. The present work aimed analyse the interactions of the ligand bounded to the activity site to provid a clear and depth vision of that interaction. For this purpouse, it was conducted an in silico study, by using quantum mechanical calculations based on Density Functional Theory (DFT), with Generalized Gradient approximation (GGA) to describe the effects of exchange and correlation. The interaction energy of each amino acid belonging to the binding site to the ligand was calculated the using the method of molecular fragmentation with conjugated caps (MFCC). Besides energy, we calculated the distances, types of molecular interactions and atomic groups involved. The theoretical models used were satisfactory and show a more accurate description when the dielectric constant = 20 ε and 80 was used. The results demonstrate that the interaction energy of the system reached convergence at 13.5 A. Within a radius of 13,5A the most important residues were identified. Met49, Met84 and Asp81 perform interactions of hydrogen with the ligant. The Asp79 and Asp75 residues present high energy of attraction. Arg54, Arg85 and Lys 131 perform hydrogen interactions with the ligand, however, appear in BIRD graph having high repulsion energy with the inhibitor. The data also emphasizes the importance of residue Tyr161 and the involvement of the catalytic triad composed by Asp75, His51 and Ser135

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Innovation has become an increasingly central issue of great reputation, not only in literature but also in management practices, becoming a strategic issue for managers of organizations. Allied to this, there is a high degree of competitiveness on the market, which contributes to the complexity of decision making, since managers need to maintain a continuous cycle of renewal processes and products. Thus, market pressures for new alternatives encourage innovation within organizations as a foundation for culture change in pursuit of survival and increased competitiveness, making it essential to know the factors that promote the advancement of organizational environments targeted innovation. Confirming this view, Bouchikhi and Kimberly (2001) symbolically expressed the idea with two statements: (1) companies need to innovate to survive, otherwise they die; and (2) the wide recognition of this need, as well as the difficulty to encourage and support innovation and entrepreneurship in business, has generated a mini-industry research and consulting in management focused on these topics. This study is characterized as descriptive with qualitative and quantitative methods. As for the planning of the research, it was decided to bibliographical research and the case study. The research, developed here, is meant to examine the organizational environment of a laboratory focused on technological innovation in health, which is a reference in research and technology of Rio Grande do Norte, and ensure that it presents opportunities to develop innovations. Therefore, the technologies developed by the Laboratório de Inovação Tecnológica em Saúde - LAIS/UFRN were mapped and then a questionnaire with the stakeholders of LAIS/UFRN was applied. This questionnaire is closed and Likert scale. As a result, it follows that the dimensions 1, 6, 7 and 8 are the most influential to form an innovative environment at LAIS.

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Triamcinolone is a relevant anti-inflammatory costicosteroid drug, used mainly by injectable suspensions due its poor water solubility. The association of triamcinolone with cyclodextrins and co-solvents (triethanolamine TEA and N-methylpirrolidone NMP) was held to solubilize the drug and explain the involved interactions. Phase-solubility diagrams showed that triamcinolone was solubilized forming incredible stable complexes with cyclodextrins, in which bests results were observed applying randomyl-methylated-beta-cyclodextrin (RMβCD) (161 fold on increased solubility). The co-solvents TEA and NMP also enhanced drug solubility 1.4 and 6.7 fold, respectively. The association of both co-solvents with CDs seems decreased complexation stability, but enables higher amount of uncomplexed drug. Experimental magnetic resonance 2D-ROESY and theoretical molecular modeling studies demonstrated TRI-CDs interactions and elucidated the structure of formed complex, which occurred due to the inclusion of ring A of TRI on CDs cavity. Physicochemical aspects of solid binary and ternary complexes prepared by spray drying were assessed by using FTIR, X-ray diffraction and SEM photographs. Dissolution studies showed that binary and ternary associations presented higher dissolution efficacy in detrimental to pure drug system. In addition, the ternary complex containing TEA and RMβCD allowed drug dissolution faster than binary complex with RMβCD. Therefore, given the higher solubility and drug dissolution rate, binary and ternary complexes are new raw materials with great potential for pharmaceuticals containing triamcinolone.

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As we are aware, the classroom is emerging as a continuous build learning experiences and environment, however, for students also it functions as a place also to be due to socializing with friends. However, not always these elements complement each other, so as harmoniously as we are aware that there are many difficulties, both in the act of learning as in interpersonal relations between them. From this, we understand that it is for the school to seek ways to contemplate such issues so that they feel inserted both with regard to this learning as well as being able to interact with themselves and with others, in a participatory manner, to live well socially. Thus, we find ourselves facing a similar situation with a 9th grade class where the students had certain limitations to have a good relationship with one another, causing thus problems in learning. On the other hand, this difficulty as affectively interact with each other, also, was increased by the difficulty that some students had to speak for themselves and to show their feelings and emotions, getting even more difficult this interaction at school. Thus, we found ourselves obliged to act immediately and need to bring about change in this picture. So it came out the idea of the application of an intervening action which started taking shapefrom a pedagogical project that we developed in other classes in previous years, this time adapted to the situation experienced by the group. The project, framed in the qualitative research and characterized from the action research approach took shape, and elected as its main objective to seek possible alternatives to develop the communicative competence of students, which is why we invest in exercise oral communication (speaking and listening) in order to promote the use of language, the interpersonal involvement facilitating thus their participation both in the classroom and in social life. To fulfill this goal, we set out to develop a didactic book whose support materialized through the autobiographical narrative (molded in writing production) and worked along a structured instructional sequence in three distinctstages that dialogued with each other. Therefore, we base our study from the socio-historical conception and dialogue proposed by Bakhtin in line with the sociodiscursivo interactionism of Bronckart and resort to other scholars as Dolz and Schneuwly, Marcuschi among others. The development of all stages of the project not only has had an immediate effect on what we proposed ourselves as also yielded us very gratifying moments reinforcing to us that the classroom environment goes far beyond the fact ministering content. And that work with orality, with views on affective interaction of these students resulted in a project, so to speak, exciting.

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The process mapping is an important tool in the management of organizations, allowing better levels of productivity, quality and reciprocity concerning the implementation and decision-making. It benefits in a clear way the process organization and assures the manager a macro vision of the system. In this sense, the objective of this study is to describe the mapping process as it occurs in the Januario Cicco Maternity School–MEJC. The bibliographic and descriptive research included interviews, observations and researches in many databases. The study analyzed the limiting points of the detected flow trying to find a better comprehension of the flow of patients in the maternity in order to offer the gestors the information necessary to improve the quality of the assistance as well as a general view of the flow of patients and any change detected there. As a result, we believe that the process mapping may become a relevant factor to the organizational management of MEJC, in view that it is an element that can contribute to ease up the management of information studied, considering that the perfect change of information inside a complex system will produce improvements in all spheres of this institution.

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In this paper, we will address together the magnetic and electrical properties of a particular semiconductor, the GaMnAs. The treatment will be done analytically in the first part of the work, according to the computational method for simulation of physical systems through the implementation of the expressions obtained in the first part. All study of magnetic contribution will be made using an interaction Kondo type, using an approach by Green functions. The electrical part, which consists of the Coulomb interactions between carriers and Mn ions, will be treated within the approach of multiple scattering. The implementation of the proposed method will calculate the Green functions converged as multiple scattering solution and use them as a starting point for the calculation of the effective magnetic interactions between Mn ions mediated charge carriers. The concentration parameters were varied for Mn ions and carriers as well. The combination of these two parameters can lead to insulating, metal samples with carriers in Fermi level to low or high mobility. As a result a correlation between the obtained carrier mobility and the strength of magnetic interaction. The greater mobility, the greater the intensity of the interaction.

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Novel scientific and technological progress require to seek new sources of electricity. Such response is, inter alia, nuclear energy. Nuclear power stations currently produce around a third of the electricity and 14% of the energy consumed in the European Union. A thorough aspect in the use and development of nuclear energy as power source is safety. Nuclear facilities are designed so that the probability of an accident that may affect people and environment was very low. Reasonably, preventive emergency plans take place in the own nuclear facilities in order to mitigate and minimize the consequences, and otherwise another emergency nuclear plans take place outside facilities. Monitoring programs are also conducted in the nearby nuclear facilities, according to the Recommendation reached on 8th June 2000 by the European Commission on the application of Article 36 of the Euratom Treaty for the checking of the levels of radioactivity in the environment, in order to assess the exposure to the whole population. The main objectives of these plans are to check the presence and evolution of radioactive elements and the radiation levels in the environment; to determinate the causes of its increase, if succeed; to estimate the radiological risk to the population; to set corrected measures, if necessary; to ensure legal compliance on the premises and; to verify the suitability of effluent monitoring program to detect radionuclides leaks and transfer to the environment...

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Neospora caninum is an obligate intracellular parasite classified in the phylum Apicomplexa, characterized by the presence of the apical complex composed by micronemes proteins, rhoptries and dense granules, used by parasite during the adhesion and invasion process of the host cell. This is the mean event in infection pathogenesis generated by N. caninum and other parasites from the phylum Apicomplexa, promoting influence in the parasite biology and the interface between the parasite and its host. Therefore, molecular tools have been developed in order to identify and characterize these possible virulence factors. Thus, the present study sought to establish a specific system of genetic manipulation of N. caninum, searching for the improvement of the genetics manipulation of this parasite. So, we developed genetically depleted N. caninum to Rop9 rhoptry using the pU6-Universal CRISPR-Cas9 plasmid of T. gondii modified by the insertion of Ku80. The Rop9 depleted parasite showed important during initial phase of invasion and replication of the parasite, however it was not characterized as a potential virulence fator for N. caninum. Furthermore, T. gondii proteins were expressed in N. caninum by the use of specific vectors for this parasite, showing an heterologous system for the study of Toxoplasma proteins, due to the fact that Gra15 or Gra24 of type II T. gondii and Rop16 of type I T. gondii were expressed in N. caninum tachyzoites in a stable way and keept its biological phenotype, as already presented the former parasite, that naturaly expresses these proteins. In addition, it was observed that N. caninum induced an inflammasome activation through NLRP3, ASC and Caspase-1. IL-1R/MyD88 demonstrated an indirect pathway in the control of parasite replication. Furthermore, it was observed that this activation is dependent of the potassium efflux and that different strains of N. caninum keep this activation profile. However, T. gondii strains block this activation, making necessary a prior signal in order to active the inflamosome pathway. Type I T. gondii Rop16 was identified as responsible for blocking this activation, in a dependent way to the STAT3 activation. Therefore, the development of molecular tools and their application in N. caninum may prove to be useful to identify and characterize virulent factors involved in the pathogenesis by these two protozoans.

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O presente relatório, realizado no âmbito da Prática de Ensino Supervisionada do Mestrado em Educação Pré-Escolar, é composto por duas partes: Dimensão Reflexiva e Dimensão Investigativa. Na Dimensão Reflexiva é apresentada uma reflexão sobre a prática em contexto de creche e de jardim de infância. Nesta dimensão são focados os aspetos que considerei mais significativos, como as minhas aprendizagens e dúvidas ou o que é ser educador de infância. A Dimensão Investigativa refere-se a um ensaio investigativo realizado no contexto de creche, com a finalidade de saber quais as interações que as crianças com idades compreendidas entre os 12 e os 24 meses estabelecem entre si, no momento de brincadeira livre, ao redor e dentro da casinha. Seguindo uma metodologia qualitativa, apresentam-se os participantes, os instrumentos de recolha de dados e os procedimentos, bem como os resultados e a sua análise. Os resultados evidenciam que as crianças estabelecem, predominantemente, interações não-verbais com os seus pares, ideia corroborada por Alexandre e Vieira (2004). Investigando com as crianças, no contexto de jardim de infância, revela-se o projeto desenvolvido sobre as abelhas, seguindo a metodologia de trabalho de projeto. Com as crianças descobrimos que as abelhas têm seis patas, que recolhem o pólen das flores, que vivem numa colmeia e que têm três tamanhos diferentes.

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O relatório que se apresenta foi realizado no âmbito do Mestrado em Educação Pré-Escolar e Ensino do 1.º Ciclo do Ensino Básico e encontra-se dividido em duas partes: a Parte I referente à dimensão reflexiva e a Parte II referente à dimensão investigativa. A parte I do relatório apresenta um relato com uma reflexão crítica e fundamentada sobre o percurso vivenciado nos contextos de Educação de Infância e de 1.º Ciclo, procurando-se evidenciar as experiências vivenciadas que permitiram aprendizagens a nível profissional, pessoal e social. Apresenta ainda uma introspeção sobre a futura professora e educadora que pretendo ser. A parte II do relatório apresenta um ensaio investigativo de caráter qualitativo desenvolvido em jardim de infância. Este incide na análise das interações estabelecidas entre uma criança com multideficiência e os seus pares, pelo que os objetivos delineados são os seguintes: (i) Identificar e caracterizar as interações da criança com multideficiência e os seus pares; (ii) Analisar com que frequência ocorrem as interações dos pares com a criança com multideficiência; (iii) Analisar com que frequência ocorrem as interações da criança com multideficiência e os seus pares. Os dados recolhidos evidenciam que neste grupo de crianças existem dois sentidos de interações, nomeadamente os momentos em que os pares da criança com multideficiência tomam a iniciativa de interagir com ela e os momentos em que a criança com multideficiência toma a iniciativa de continuar as interações com os pares. Destaca-se também a ideia de que as crianças estabeleciam interações com e sem objetos, sendo este um mediador dessas interações que eram do tipo verbal e não-verbal.

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O presente trabalho surge no âmbito do mestrado em Ciências da Educação - Especialização em Utilização Pedagógica das Tecnologias da Informação e Comunicação, da Escola Superior e Ciências Sociais do Instituto Politécnico de Leiria, no ano lectivo 2013/2014. Seguindo uma metodologia qualitativa, de índole descritiva e exploratória, procurámos estudar as interações entre pares e adultos aquando da utilização do software educativo “O Meu Baú dos Brinquedos” (Faria, P. & Faria, C., 2001) – software vencedor do XI Concurso Nacional de Software Educacional, no âmbito do programa Nónio Século XXI. Para a realização deste estudo, contámos com a participação de duas crianças de 5 anos do Jardim de Infância da rede pública de Oliveira do Hospital que, ao longo de 2 sessões, interagiram entre si e com a investigadora aquando da utilização do software em análise. Recorrendo ao registo videográfico, sua transcrição e posterior análise de conteúdo foi possível inferir que o software em estudo poderá estimular a interação entre pares (principalmente através da comunicação não verbal), promovendo o desenvolvimento e a aprendizagem de crianças ao nível da área de comunicação e expressão do domínio da matemática (Ministério da Educação, 1997a), nomeadamente na discussão de atividades e na resolução de problemas. Estes dados, ainda que exploratórios, darão indicações sobre o potencial pedagógico dos videojogos / softwares educativos para a educação pré-escolar.

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O presente relatório foi elaborado no âmbito do Mestrado em Educação Pré-Escolar e Ensino do 1.º Ciclo do Ensino Básico, estando organizado em duas dimensões. A primeira dimensão, a reflexiva, consiste na apresentação do percurso que realizei ao longo das práticas pedagógicas nos diferentes contextos, evidenciando as experiências mais significativas, algumas propostas educativas implementadas, as dificuldades e os desafios que surgiram e as aprendizagens realizadas. Na dimensão investigativa dou a conhecer o estudo de carácter qualitativo, na forma de estudos de caso, desenvolvido com três crianças de três anos, no contexto de Jardim de Infância. Esta investigação procurou conhecer as brincadeiras desenvolvidas por três crianças no momento de brincadeira livre, permitindo-me descrever as interações estabelecidas com os pares e identificar a tipologia das brincadeiras, tanto pelo seu conteúdo, como pela sua dimensão social. Os dados revelaram a envolvência das crianças em todos os tipos de brincadeira, evidenciando-se a predominância das brincadeiras faz-de-conta e cooperativa.

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Esse projeto de pesquisa traz como objetivo analisar o conhecimento dos alunos do Colégio Técnico Industrial de Santa Maria em relaçao aos seis momentos do jogo de Voleibol, de forma a comparar este entendimento entre os alunos inseridos na aula de Educaçao Física com os da equipe de Voleibol do Colégio. Recorreu-se a elaboraçao de um questionário sobre a referida temática a ser aplicado aos alunos da escola, das quais as primeiras sao questoes fechadas e as demais abertas. Pretende-se com os possíveis e futuros resultados demonstrar a relevância e a importância dessas interaçoes de cooperaçao e oposiçao acerca dos momentos do jogo de Voleibol, para os autores consultados e para os alunos do CTISM de forma a comparar os devidos questionários com seus respectivos conhecimentos acerca do assunto; salientar a importância da Praxiologia Motriz e a contribuiçao da mesma para o Voleibol como Jogo Esportivo Coletivo, auxiliando no processo de ensino- aprendizagem do mesmo e servindo como uma ferramenta que norteie e dê base ao treinamento de Voleibol desenvolvido pelo CTISM