Information Guide: Human Rights in Europe

A guide to Human Rights within the European Union and in the wider Europe, with hyperlinks to sources of information within European Sources Online and on external websites

Impaired renal endothelial nitric oxide synthase and reticulocyte production as modulators of hypertension induced by recombinant human erythropoietin in the rat

INTRODUCTION AND AIMS: Hypertension is a common side effect of recombinant human erythropoietin (rHuEPO) therapy; however, the exact pathways remain to be elucidated. The discovery of non-hematopoietic actions of rHuEPO increased the number of patients that could putatively benefit from this therapy; however, to achieve those effects higher doses are usually needed, which increase the risk and incidence of adverse events. Our aim was to study the effect of a broad range of rHuEPO doses on hematological and biochemical parameters, blood pressure and renal function and damage in the rat, focusing on endothelial nitric oxide synthase (eNOS) and hypoxia-inducible factors (HIFs). METHODS: Male Wistar rats were divided in 5 groups receiving different doses of rHuEPO (100, 200, 400 and 600 IU/kg body weight (BW)/week) and saline solution (control), during 3 weeks. Blood and 24h urine were collected to perform hematological and biochemical analysis. Blood pressure (BP) was measured by the tail-cuff method. The kidney tissue was collected to mRNA and protein expression assays and to characterize renal lesions. RESULTS: A dose-dependent increase in red blood cells count, hematocrit and hemoglobin levels was found with rHuEPO therapy, in rHuEPO200, rHuEPO400 and rHuEPO600 groups. Increased reticulocyte count was found in the rHuEPO400 and rHuEPO600 groups. BP raised in all groups receiving rHuEPO. The rHuEPO200 and rHuEPO600 groups presented increased kidney protein levels of HIF2α and a reduction in kidney protein levels of eNOS, along with the highest grade of vascular and tubular renal lesions. CONCLUSIONS: Our study showed that rHuEPO-induced hypertension might involve indirect (hematological) and direct (renal) effects which varies according to the dose used. Thus, rHuEPO therapy should be performed rationally and under adequate surveillance, as hypertension develops even with lower doses. Especial caution with higher doses should be taken, as rHuEPO-induced hypertension leads to early renal damage without alterations in traditional markers of renal function, thus masking the serious adverse effects and risks.

A survey of the literature on income distribution and the fulfillment of basic human needs in the Caribbean region /

Bibliography: p. [62]-64.

Human rights in El Salvador [microform] : hearings before the Subcommittees on Human Rights and International Organizations and on Western Hemisphere Affairs of the Committee on Foreign Affairs, House of Representatives, Ninety-eighth Congress, first session, July 26, 1983.

CIS Microfiche Accession Numbers: CIS 83 H381-89

Human rights in Nicaragua, Guatemala, and El Salvador : implications for U.S. policy : hearings before the Subcommittee on International Organizations of the Committee on International Relations, House of Representatives, Ninety-fourth Congress, second session, June 8 and 9, 1976.

Includes bibliographical references.

Human rights in Guatemala : hearing before the Subcommittees on Human Rights and International Organizations and on Inter-American Affairs of the Committee on Foreign Affairs, House of Representatives, Ninety-seventh Congress, first session, July 30, 1981.

Item 1017-A, 1017-B (microfiche)

Human rights in Haiti : hearing before the Subcommittee on International Organizations of the Committee on International Relations, House of Representatives, Ninety-fourth Congress, first session, November 18, 1975.

"Report of Senator Edward W. Brooke, 'United States foreign assistance for Haiti', April 1974": p. 73-120.

Human rights in Chile : hearings before the Subcommittees on Inter-American Affairs and on International Organizations and Movements of the Committee on Foreign Affairs, House of Representatives, Ninety-third Congress, second session ...

Subcommittees' names in reverse order in pt. 2.

The higher life in art : a series of lectures on the Barbizon school of France, inaugurating the Scammon course at the Art Institute of Chicago /

Includes index.

Old masters and new; essays in art criticism,

Reprinted from various periodicals.

The Modern world dictionary of the English language ... to which is added a compendium of historical, biographical, geographical, scientific, religious, and sociological names, and a complete summary of human achievement in the nineteenth & twentieth centuries ...

Editors-in-chief: Robert Hunter and Charles Morris.

Oh! fickle taste; or, Objectivity in art.

Mode of access: Internet.