869 resultados para Cain, Susan
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[Exposition. Paris, Opéra national de Paris. 1938]
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La trufa negra aparece de forma silvestre entre otros lugares en la Sierra de Javalambre (Teruel), donde desde hace 15 años se han establecido plantaciones de trufa con la intención de cultivar este "tesoro culinario". La información extraída de este estudio, basado en encuestas realizadas a personas vinculadas al cultivo de la trufa en esta Región, tiene como objetivo estimar el impacto socioeconómico de este cultivo en ciertas regiones,comparando su beneficio con los cultivos tradicionales de estas zonas.
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OBJECTIVES: Leri's pleonosteosis (LP) is an autosomal dominant rheumatic condition characterised by flexion contractures of the interphalangeal joints, limited motion of multiple joints, and short broad metacarpals, metatarsals and phalanges. Scleroderma-like skin thickening can be seen in some individuals with LP. We undertook a study to characterise the phenotype of LP and identify its genetic basis. METHODS AND RESULTS: Whole-genome single-nucleotide polymorphism genotyping in two families with LP defined microduplications of chromosome 8q22.1 as the cause of this condition. Expression analysis of dermal fibroblasts from affected individuals showed overexpression of two genes, GDF6 and SDC2, within the duplicated region, leading to dysregulation of genes that encode proteins of the extracellular matrix and downstream players in the transforming growth factor (TGF)-β pathway. Western blot analysis revealed markedly decreased inhibitory SMAD6 levels in patients with LP. Furthermore, in a cohort of 330 systemic sclerosis cases, we show that the minor allele of a missense SDC2 variant, p.Ser71Thr, could confer protection against disease (p<1×10(-5)). CONCLUSIONS: Our work identifies the genetic cause of LP in these two families, demonstrates the phenotypic range of the condition, implicates dysregulation of extracellular matrix homoeostasis genes in its pathogenesis, and highlights the link between TGF-β/SMAD signalling, growth/differentiation factor 6 and syndecan-2. We propose that LP is an additional member of the growing 'TGF-β-pathies' group of musculoskeletal disorders, which includes Myhre syndrome, acromicric dysplasia, geleophysic dysplasias, Weill-Marchesani syndromes and stiff skin syndrome. Identification of a systemic sclerosis-protective SDC2 variant lays the foundation for exploration of the role of syndecan-2 in systemic sclerosis in the future.
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Several methods and approaches for measuring parameters to determine fecal sources of pollution in water have been developed in recent years. No single microbial or chemical parameter has proved sufficient to determine the source of fecal pollution. Combinations of parameters involving at least one discriminating indicator and one universal fecal indicator offer the most promising solutions for qualitative and quantitative analyses. The universal (nondiscriminating) fecal indicator provides quantitative information regarding the fecal load. The discriminating indicator contributes to the identification of a specific source. The relative values of the parameters derived from both kinds of indicators could provide information regarding the contribution to the total fecal load from each origin. It is also essential that both parameters characteristically persist in the environment for similar periods. Numerical analysis, such as inductive learning methods, could be used to select the most suitable and the lowest number of parameters to develop predictive models. These combinations of parameters provide information on factors affecting the models, such as dilution, specific types of animal source, persistence of microbial tracers, and complex mixtures from different sources. The combined use of the enumeration of somatic coliphages and the enumeration of Bacteroides-phages using different host specific strains (one from humans and another from pigs), both selected using the suggested approach, provides a feasible model for quantitative and qualitative analyses of fecal source identification.
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On trouvera ici un recueil des grands textes médicaux, littéraires, de philosophie et de sciences sociales sur l'expérience de la maladie et du soin. Il révèle combien cette expérience était déjà au coeur de la pensée la plus classique, mais aussi comment elle est devenue classique dans la pensée la plus contemporaine. D'Hippocrate à Georges Canguilhem, de Tolstoï à Susan Sontag, de Montaigne à Michel Foucault et Erving Goffman, ces classiques permettent d'appréhender les tensions les plus profondes et actuelles du soin : geste technique et relation éthique ; souci de soi et présence à l'autre ; quête de sens et travail ; solidarité et risque d'exclusion ; raison d'être ou point aveugle de la médecine. Chaque texte est suivi d'un commentaire destiné aux étudiants de philosophie et de médecine (notamment de Première Année Commune des Études de Santé) et à tous ceux qu'intéressent les dimensions scientifiques, éthiques et sociales du soin.
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On trouvera ici un recueil des grands textes médicaux, littéraires, de philosophie et de sciences sociales sur l'expérience de la maladie et du soin. Il révèle combien cette expérience était déjà au coeur de la pensée la plus classique, mais aussi comment elle est devenue classique dans la pensée la plus contemporaine. D'Hippocrate à Georges Canguilhem, de Tolstoï à Susan Sontag, de Montaigne à Michel Foucault et Erving Goffman, ces classiques permettent d'appréhender les tensions les plus profondes et actuelles du soin : geste technique et relation éthique ; souci de soi et présence à l'autre ; quête de sens et travail ; solidarité et risque d'exclusion ; raison d'être ou point aveugle de la médecine. Chaque texte est suivi d'un commentaire destiné aux étudiants de philosophie et de médecine (notamment de Première Année Commune des Études de Santé) et à tous ceux qu'intéressent les dimensions scientifiques, éthiques et sociales du soin.
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El artículo trata de las contribuciones autobiográficas de lingüistas a la historiografía. Considera la autobiografía como una fuente documental de la corriente narrativa de la historiografía. Hace un inventario de los repertorios de autobiografías: Davis & O"Cain 1980, Koerner , 1991, 1998; López Alonso & Séré , 1992; Swiggers , 1997; Brown & Law, 2002; Timotin & Colceriu, 2012; Laborda, Romera & Fernández Planas, 2014 . Y considera sus aspectos cognitivos, literarios y textuales. A plica como modelo analítico la teoría del dramatismo y de los constituyentes del relato de Jerome Bruner. El estudio argumenta sobre la idoneidad de la autobiografía para narrar la trayectoria vital del autor y trazar el panorama de la lingüística contemporánea. Y revela el valor polifacético de la escritura del Yo como literatura, documento científico y fuente de información social."Historiography and memory of linguistics in autobiographies of linguistics The paper discusses the autobio graphical historiography of linguistics contributions. The autobiography is a source of the narrative aspect of historiography. In the paper a list of autobiographies of linguists is made (Davis & O"Cain 1980,Koerner 1991 y 1998, López Alonso & Séré 1992, Swiggers 1997, Brown & Law 2002, Timotin & Colceriu 2012, Laborda, Romera & Fernández Planas 2014) to consider their cognitive, literary and textual aspects .The article applies the theory as an analytical model of the drama and of the constituents of the story by Jerome Bruner. The study confirms the suitability of the autobiography to tell the life story of the author and to describe the landscape of contemporary linguistics.
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The University of Brasília (UnB) uses a diversity of chemical products, generating residues in a significant way in its multiple activities - teaching, research and community services. The UnB Comission on Chemical Residues Management was established in November 2002, aiming at three main objectives: 1) correct destination for the accumulated residues; 2) implantation of a chemical residues management system and 3) implantation of a UnB Unit for Treatment of Chemical Residues. To fulfil these commitments, a diagnosis of chemical residues produced by the University was performed, which is here presented with an evaluation of their future use, limitations and possibilities.
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Offentlig föreläsning vid professorsinstallation vid Åbo Akademi den 20 april 2007.
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Naistutkimuspäivät, marraskuu 2005, Helsingin kauppakorkeakoulu ja Svenska Handelshögskolan.
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Kirjallisuusarvostelu
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O estudo do carbono assume grande importância devido à sua estreita relação com as mudanças climáticas da Terra. Uma das causas relevantes dessas alterações é a rápida substituição das florestas tropicais da Amazônia por sistemas agropecuários. Este trabalho foi desenvolvido em Juruena (MT), com os seguintes objetivos: estudo da distribuição espacial do teor de carbono e a estimativa do seu estoque na camada de 0-0,60 m de solo em microbacias sob floresta primária, por meio de técnicas geoestatísticas. Foram demarcados 185 pontos georreferenciados em forma de malha sistemática regular, abrangendo quatro microbacias próximas, com espaçamento de 20 x 20 m, em que foram coletadas amostras de solo até a profundidade de 0,60 m. A densidade aparente aumentou de 1,36 ± 0,081 g.cm-3 (± desvio-padrão) para 1,46 ± 0,083 g.cm-3, nas profundidades de 0-0,20 m e 0,40-0,60 m, respectivamente. As microbacias apresentaram estoques médios de carbono (profundidade de 0-0,60 m) distribuídos da seguinte forma: microbacia 1 = 56,73 t.ha-1, microbacia 2 = 59,35 t.ha-1, microbacia 3 = 59,22 t.ha-1 e microbacia 4 = 64,35 t.ha-1, com média geral de 59,74 ± 10,30 t.ha-1. Apesar de existir uma aparente homogeneidade quanto às características visíveis na paisagem, como relevo, cor de solo e vegetação, os atributos carbono e argila apresentaram considerável variabilidade, mesmo dentro de pequenos espaços como as microbacias estudadas. Isso demonstrou que a extrapolação de dados para estimativas de estoque de carbono em áreas maiores pode projetar resultados falsos, quando a variabilidade espacial de atributos de solo não é levada em consideração.