Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.

Projecte de restauració mediambiental d'una zona humida degradada per una antiga extractiva a La Roca del Vallès (Vallès Oriental)

L'objectiu del projecte és definir les característiques tècniques i les mesures derevegetació i adequació ambiental que s’han de portar a terme durant l’execució deles obres de recuperació de l’espai degradat per l’home, com a conseqüència dediverses actuacions realitzades, que han sotmès a un estat d’estrès la zona.Per a l’elaboració d’aquest projecte s’han tingut en compte les accions mésdeterminants que han comportat l’estat actual de la zona:- Activitat extractiva “Congostell”. Vilanova del Vallès (X,Y: 442527.2,4602558.8). Activitat extractiva establerta dins domini públic hidràulic. Ubicada, en la seva major part, al municipi de Vilanova del Vallès i enuna menor superfície, dins l’àmbit del projecte. Durant el període defuncionament de l’extractiva, es va extreure força material de la zona d’estudi. Actualment no està en actiu i no s’ha iniciat la restauració.- Obra civil “Projecte Artèria Planta del Ter – Estació de la Trinitat Tram II. LaRoca del Vallès – Montornés del Vallès”. És una obra consistent en el soterrament d’una canonada de diàmetre 2200mm per transport d’aigua i no contemplada en el Pla General d’Ordenació Municipal. - Obra civil “Projecte Artèria Planta del Ter – Estació de la Trinitat Tram II. La Roca del Vallès – Montornés del Vallès”. És una obra consistent en el soterrament d’una canonada de diàmetre 2200mm per transport d’aigua i no contemplada en el Pla General d’Ordenació Municipal. - Obra civil de la construcció del tren d’Alta Velocitat Espanyol (AVE),concretament la línia Madrid-Zaragoza-Barcelona-Frontera Francesa.S’utilitza part de l’àmbit d’estudi com acopi de terres sobrants de l’obra Aquestes activitats han afectat de forma desigual la zona on s’ubica el projecte. L’activitat extractiva i la canonada d’aigua han afectat directament el terreny, ja que tots els treballs de l’activitat han tingut lloc dins l’àmbit d’estudi, mentre que la construcció de l’AVE ha comportat el pas de camions per la zona i l’abocament de les terres.El promotor del projecte és l’Ajuntament de La Roca del Vallès (Vallès Oriental)

Domestic architecture and social differences in North-Eastern Iberia during the iron age (c.525-200 BC)

This paper is concerned with the organization of societies in north-eastern Iberia (present-day Catalonia) during the Iron Age, using data provided by domestic architecture and settlement organization. I offer an analysis of the social differences detected in the dwellings based on a sample of houses excavated at different types of settlement. Although many Iberian houses had simple layouts and small surface areas, some larger dwellings at the main sites are distinguished by the shape of their ground plans, their surface areas, architectural features, and central locations; these houses are believed to be the residences of the Iberian elite. Such dwellings are not found at all sites and the data suggest that there was a relationship between the category of the settlement (or its function) and the types of dwelling in it.

Dictionnaire d'architecture civile et hydraulique et des arts qui en dépendent : comme la maçonnerie, la charpenterie, la menuiserie... ([Reprod.]) / par Augustin Charles d'Aviler...

Collection : Archives de la linguistique française ; 18

Des principes de l'architecture, de la sculpture, de la peinture, et des autres arts qui en dépendent : avec un Dictionnaire des termes propres à chacun de ces arts (Ed. sur microfiche) / [Félibien]

Collection : Archives de la linguistique française ; 151

The micro-architecture estimation by TBS discriminate women with and without osteoporotic fracture independently of age, BMI and BMD: The Osteo-Mobile Vaud cohort study.

Introduction: « Osteo-Mobile Vaud » is a mobile osteoporosis (OP) screening program. The women > 60 years living in the region Vaud will be offered OP screening with new equipment installed in a bus. The main goal is to evaluate the fracture risk with the combination of clinical risk factors (CRF) and informations extracted by a single DXA: bone mineral density (BMD), vertebral fracture assessment (VFA), and micro-architecture (MA) evaluation. MA is yet evaluable in daily practice by the Trabecular Bone Score (TBS) measure. TBS is a novel grey-level texture measurement reflecting bone MA based on the use of experimental variograms of 2D projection images. TBS is very simple to obtain, by reanalyzing a lumbar DXA-scan. TBS has proven to have diagnosis and prognosis value, partially independent of CRF and BMD. A 55-years follow- up is planned. Method: The Osteo-Mobile Vaud cohort (1500 women, > 60 years, living in the region Vaud) started in July 2010. CRF for OP, lumbar spine and hip BMD, VFA by DXA and MA evaluation by TBS are recorded. Preliminary results are reported. Results: In July 31th, we evaluated 510 women: mean age 67 years, BMI 26 kg/m². 72 women had one or more fragility fractures, 39 had vertebral fracture (VFx) grade 2/3. TBS decreases with age (-0.005 / year, p<0.001), and with BMI (-0.011 per kg/m², p<0.001). Correlation between BMD and site matched TBS is low (r=0.4, p<0.001). For the lowest T-score BMD, odds ratio (OR, 95% CI) for VFx grade 2/3 and clinical OP Fx are 1.8 (1.1-2.9) and 2.3 (1.5-3.4). For TBS, age-, BMI- and BMD adjusted ORs (per SD decrease) for VFx grade 2/3 and clinical OP Fx are 1.9 (1.2-3.0) and 1.8 (1.2-2.7). The TBS added value was independent of lumbar spine BMD or the lowest T-score (femoral neck, total hip or lumbar spine). Conclusion: As in the already published studies, these preliminary results confirm the partial independence between BMD and TBS. More importantly, a combination of TBS and BMD may increase significantly the identification of women with prevalent OP Fx. For the first time we are able to have complementary information about fracture (VFA), density (BMD), and micro-architecture (TBS) from a simple, low ionizing radiation and cheap device: DXA. The value of such informations in a screening program will be evaluated.

Flutuação populacional e controle da mariposa oriental (Grapholita molesta Busck, 1916) em produção convencional e integrada de pessegueiro

Este trabalho foi realizado nos anos de 2000 e 2001, em um pomar comercial de pessegueiro 'Marli', no município de São Jerônimo, RS, latitude 30º05'52" S, longitude 51º39'08" W e altitude de 46 metros. A população de Grapholita molesta (Busck, 1916) foi monitorada com o objetivo de comparar as técnicas de controle preconizados no sistema de Produção Integrada (PI) e Convencional (PC), bem como seus reflexos nos danos em frutos e plantas de cada sistema. Em ambos os anos, o uso de monitoramento na PI mostrou-se eficiente para diminuir a população a níveis baixos e dentro do limite de três aplicações de inseticidas para o controle do inseto, quando comparado com a PC. Neste tipo de produção, as aplicações foram realizadas a cada 10 dias a partir de outubro, em um total de sete aplicações no primeiro ano e nove no segundo. Com relação aos danos em frutos e ponteiros, o monitoramento na PI permitiu um controle tão eficiente quanto na PC, com a vantagem da diminuição do número de aplicações dos agroquímicos. O monitoramento mostrou-se eficiente na redução do número de aplicações de agroquímicos, com considerável redução nos custos de produção de pêssego e menor impacto sobre o meio ambiente.

Information architecture for the semantic web

L'objectiu és desenvolupar i avaluar una sèrie de components de l'arquitectura de la informació per a la web semàntica. Aquest components són genèrics i permeten als usuaris explorar conjunts de dades semàntiques sense necessitat de conèixer l'estructura ni tenir coneixements tècnics. S'ha desenvolupat seguint una metodologia de disseny centrat en l'usuari

Espaces et sociétés : revue critique internationale de l'aménagement, de l'architecture et de l'urbanisation / dir. publ. Serge Jonas

1977/03 (N20)-1977/06 (N21).

Espaces et sociétés : revue critique internationale de l'aménagement, de l'architecture et de l'urbanisation / dir. publ. Serge Jonas

1998 (N95,T1).

Espaces et sociétés : revue critique internationale de l'aménagement, de l'architecture et de l'urbanisation / dir. publ. Serge Jonas

1976/03 (N17)-1976/06 (N18).