Probing into the role of conserved N-glycosylation sites in the Tyrosinase glycoprotein family

N-linked glycosylation has a profound effect on the proper folding, oligomerization and stability of glycoproteins. These glycans impart many properties to proteins that may be important for their proper functioning, besides having a tendency to exert a chaperone-like effect on them. Certain glycosylation sites in a protein however, are more important than other sites for their function and stability. It has been observed that some N-glycosylation sites are conserved over families of glycoproteins over evolution, one such being the tyrosinase related protein family. The role of these conserved N-glycosylation sites in their trafficking, sorting, stability and activity has been examined here. By scrutinizing the different glycosylation sites on this family of glycoproteins it was inferred that different sites in the same family of polypeptides can perform distinct functions and conserved sites across the paralogues may perform diverse functions.

Strauss family portrait; Würzburg.

Seated front center is grandmother Ernestine Strauss nee Uhlfelder (died before 1914, second wife of Leopold (Laemmle) Strauss) surrounded by six grandchildren; Benno Strauss is standing far left

Studio portrait of the women of the Oppenheimer family.

l-r: Thekla Oppenheimer-Benedick, Jenny Oppenheimer-Frank, Fanny Oppenheimer and Adele Oppenheimer-Nathan

Studio portrait of the women of the Oppenheimer family.

l-r: Sisters Adele Oppenheimer-Nathan, Thekla Oppenheimer-Benedick, Jenny Oppenheimer-Frank and their mother Fanny Oppenheimer

Benno Strauss with unidentified family members; Edel-Str. 6, Würzburg.

Verso: handwritten correspondence

Portrait of brothers Moshe Chayim Eliasberg (on left) and Samuel Eliasberg playing chess watched by Moshe's son Mulek Eliasberg Portraits Family

Moshe Chayim Eliasberg died 1920; Samuel Eliasberg died 1929; Mulek Eliasberg, 1886-1942

Portrait of a family and their dog sitting in a park Portraits Family

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Portrait of brother, mother and sister of Max Rieser seated outdoors; Franzensbad Portraits Family

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Schloss and Schoeneberg family portrait on the occasion of the 80th birthday of Jeanette Bildesheim nee Schoeneberg.

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Benno Strauss (far right) with unidentified family members.

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Pedigree of the Jacob family of Stavenhagen, Mecklenburg, Germany.

Family tree and genealogy of Jacob family in Stavenhagen, Mecklenburg, 1690-1975.

Family portrait at double wedding ceremony of the Heimann and Rosenfelder families Portraits; Family

Double Wedding Ceremony Heimann-Rosenfelder August 17, 1909

Painting of Freiherr Martin von Magnus Family Portraits Family

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Achtentuch family portrait; Odessa Portraits Family

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Jacob Picard with daughter Renate Portraits Family

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