Iowa Board of Nursing Annual Report, July 12, 2004-June 30,2005

Annual report of the Iowa Board of Nursing. Includes information on legislation, rule changes, and statistics related to all aspects of board business: education, continuing education, enforcement, administrative changes, financial report and general nursing demographics.

Wear of two artificial tooth materials in vivo: a 12-month pilot study.

STATEMENT OF PROBLEM: Wear of methacrylate artificial teeth resulting in vertical loss is a problem for both dentists and patients. PURPOSE: The purpose of this study was to quantify wear of artificial teeth in vivo and to relate it to subject and tooth variables. MATERIAL AND METHODS: Twenty-eight subjects treated with complete dentures received 2 artificial tooth materials (polymethyl methacrylate (PMMA)/double-cross linked PMMA fillers; 35%/59% (SR Antaris DCL, SR Postaris DCL); experimental 48%/46%). At baseline and after 12 months, impressions of the dentures were poured with improved stone. After laser scanning, the casts were superimposed and matched. Maximal vertical loss (mm) and volumetric loss (mm(3)) were calculated for each tooth and log-transformed to reduce variability. Volumetric loss was related to the occlusally active surface area. Linear mixed models were used to study the influence of the factors jaw, tooth, and material on adjusted (residual) wear values (alpha=.05). RESULTS: Due to drop outs (n=5) and unmatchable casts (n=3), 69% of all teeth were analyzed. Volumetric loss had a strong linear relationship to surface area (P<.001); this was less pronounced for vertical loss (P=.004). The factor showing the highest influence was the subject. Wear was tooth dependent (increasing from incisors to molars). However, these differences diminished once the wear rates were adjusted for occlusal area, and only a few remained significant (anterior versus posterior maxillary teeth). Another influencing factor was the age of the subject. CONCLUSIONS: Clinical wear of artificial teeth is higher than previously measured or expected. The presented method of analyzing wear of artificial teeth using a laser-scanning device seemed suitable.

Catalogue des vases, colonnes, tables de marbres rares, figures de bronze, porcelaines de choix, laques, meubles précieux, pendules, lustres... et autres effets importants qui composent le cabinet de feu M. le duc d'Aumont . Par P. F. Julliot fils, & A. J. Paillet. La vente se fera le 12 Décembre 1782...

[Vente. Art. 1782-12-12. Paris]

Iowa Lottery Action Newsletter, August 22-September 11, 2005, Vol. 12, no. 16

Iowa Lottery newsletter for Lottery retailers.

Iowa Lottery Action Newsletter, Dec. 12, 2005 through Jan. 8, 2006; Vol. 12, No. 23

Iowa Lottery newsletter for lottery retailers.

Footnotes, November/December 2005, Vol. 29, no. 11-12

Monthly newsletter of the State Library

Arrest du Conseil d'Etat du Roy. Du 12 octobre 1700. Concernant les sucres bruts & non raffinez, provenants de l'isle de Cayenne, qui seront déchargez à Nantes & voiturez sans séjour à droiture par le bureau d'Ingrande...

[Acte. 1700-10-12. Fontainebleau]

EPI Update, May 12, 2006

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Motor Vehicle Accident Fatalities for the Week Ending, May 12, 2006

Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

ABD e-News May 12, 2006

Weekly Newsletter

Iowa Department of Elder Affairs Legislative Update, April 8, 2005, Vol. 1, no. 12

Iowa Department of Elder Affairs provides a brief summation of a Departmental program or other important Departmental information in each Legislative Update. The Legislative Update is produced for informational and educational purposes only.

Iowa Department of Elder Affairs Legislative Update, March 31, 2006, Vol. 2, no. 12

Iowa Department of Elder Affairs provides a brief summation of a Departmental program or other important Departmental information in each Legislative Update. The Legislative Update is produced for informational and educational purposes only.

Iowa Lottery Action, June 19-July 9, 2006, Vol. 13, no. 12

Iowa Lottery newsletter for Lottery retailers.

Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.

Glucagon-like peptide-1 (GLP-1) stimulates glucose-induced insulin secretion by binding to a specific G protein-coupled receptor linked to activation of the adenylyl cyclase pathway. Here, using insulinoma cell lines, we studied homologous and heterologous desensitization of GLP-1-induced cAMP production. Preexposure of the cells to GLP-1 induced a decrease in GLP-1-mediated cAMP production, as assessed by a 3- to 5-fold rightward shift of the dose-response curve and an approximately 20 percent decrease in the maximal production of cAMP. Activation of protein kinase C by the phorbol ester phorbol 12-myristate 13-acetate (PMA) also induced desensitization of the GLP-1-mediated response, leading to a 6- to 9-fold shift in the EC50 and a 30% decrease in the maximal production of cAMP. Both forms of desensitization were additive, and the protein kinase C inhibitor RO-318220 inhibited PMA-induced desensitization, but not agonist-induced desensitization. GLP-1- and PMA-dependent desensitization correlated with receptor phosphorylation, and the levels of phosphorylation induced by the two agents were additive. Furthermore, PMA-induced, but not GLP-1-induced, phosphorylation was totally inhibited by RO-318220. Internalization of the GLP-1 receptor did not participate in the desensitization induced by PMA, as a mutant GLP-1 receptor lacking the last 20 amino acids of the cytoplasmic tail was found to be totally resistant to the internalization process, but was still desensitized after PMA preexposure. PMA and GLP-1 were not able to induce the phosphorylation of a receptor deletion mutant lacking the last 33 amino acids of the cytoplasmic tail, indicating that the phosphorylation sites were located within the deleted region. The cAMP production mediated by this deletion mutant was not desensitized by PMA and was only poorly desensitized by GLP-1. Together, our results indicate that the production of cAMP and, hence, the stimulation of insulin secretion induced by GLP-1 can be negatively modulated by homologous and heterologous desensitization, mechanisms that involve receptor phosphorylation.