Overdeepened glacial basins as archives for the Quaternary landscape evolution of the Alps

The Alps and the Alpine foreland have been shaped by repeated glaciations during Quaternary glacial-interglacial cycles. Extent, timing and impact on landscape evolution of these glaciations are, however, poorly constrained due to the fragmentary character of terrestrial archives. In this context, the sedimentary infills of subglacially eroded, ‘overdeepened’, basins may serve as important archives to complement the Quaternary stratigraphy over several glacial-interglacial cycles. In this thesis, the infills of deep subglacial basins in the Lower Glatt valley (N Switzerland) are explored to better constrain the Middle- to Late Pleistocene environmental change. Five drill cores gave direct insight into to the up to ~200 m thick valley fill at the study site and allowed for detailed analysis of sedimentary facies, age and architecture of the basin fills. A first focus is set on the sedimentology of coarse-grained diamicts with sorted interbeds overlying bedrock in the trough center, which mark the onset of deposition in many glacial bedrock troughs. Evidence from macro- and microsedimentology suggests that these sediments are emplaced subglacially and reflect deposition, reworking and deformation in response to repeated coupling and decoupling of the ice-bed interface promoted by high basal water pressures. Overlying these subglacial sediments, large volumes of sandy glacio-deltaic, fine-grained glacio-lacustrine and lacustrine sediments document sedimentation during glacier retreat from the basins. On these thick valley fill sequences the applicability and reliability of luminescence dating is investigated in a second step on the basis of experiments with several different luminescence signals, protocols and experiments to assess the signal stability. The valley fill of the Lower Glatt valley is then grouped into nine depositional cycles (Formations A-I), which are related to the Birrfeld Glaciation (~MIS2), the Beringen Glaciation (~MIS6), and up to three earlier Middle Pleistocene glaciations, tentatively correlated to the Hagenholz, Habsburg, and Möhlin Glaciations, according to the regional glaciation history. The complex bedrock geometry and valley fill architecture are shown to be the result of multiple erosion and infilling cycles and reflect the interplay of subglacial erosion, glacial to lacustrine infilling of overdeepened basins, and fluvial down-cutting and aggradation in the non-overdeepened valley fill. Evidence suggests that in the study area deep bedrock incision, and/or partial re-excavation, occurred mainly during the Beringen and Hagenholz Glaciation, while older structures may have existed. Together with the observation of minor, ‘inlaid’ glacial basins, dynamic changes in the magnitude and focus of subglacial erosion over time are documented.

El estudio del cultivo de roza = The study of shifting cultivation /

Includes indexes.

Transactions of the ... annual meeting of the South Carolina Bar Association.

Includes list of members and constitution and by-laws.

As regards protoplasm / by James Hutchison Stirling.

This new ed. completed by addition of pt. II, in reference to Mr. Huxley's 2d issue; and of Preface, in reply to Mr. Huxley in "Yeast".

Des Knaben Wunderhorn. Alte deutsche Lieder,

"Anmuthiger Blumenkranz aus dem Garten der gemeinde Gottes, ans licht gegeben im Jahre 1712": v. 3, p. 203-239.

Khristomatii︠a︡ po izuchvanie slovesnostʹta. Otredena za gorniti︠e︡ klassove na gimnaziiti︠e︡, petoklassniti︠e︡, pedagogicheskiti︠e︡ i dukhovniti︠e︡ uchilishta.

t. 1. Proza (3d ed.).--t. 2. Epicheska poezii︠a︡ (2d. rev. and enl. ed.).--t. 3. Liricheska i dramaticheska poezii︠a︡.

L'art de vérifier les dates ...

Vols. [33-37 and 39-44] were written by D. B. Warden and have running title "Chronologie historique de l'Amerique."

New York, New Haven & Hartford railroad co.

The report is also published separately with title... "Letter from the Interstate commerce commission... a report concerning the financial transactions of the New York, New Haven & Hartford railroad co.," as Senate doc. 544, 63d Cong., 2d sess.; and again, with a preliminary print of the Evidence appended.

The library of American biography /

General index in last volume.

Chippewa music,

Contains music.

Report on forestry ...

"Report on the production of maple sugar in the United States and Canada, by Franklin B. Hough": v. 4. p. 394-412.

Congrès mondial des associations internationales ...

Mode of access: Internet.

Springfield in the Spanish American war,

Companies B, G, and K of the 2d infantry and Company H, Naval brigade.

Transactions of the annual meeting.

Includes list of members.

Comparative proteomic analysis of GS-NSO murine myeloma cell lines with varying recombinant monoclonal antibody production rate

We have employed an inverse engineering strategy based on quantitative proteome analysis to identify changes in intracellular protein abundance that correlate with increased specific recombinant monoclonal antibody production (qMab) by engineered murine myeloma (NSO) cells. Four homogeneous NSO cell lines differing in qMab were isolated from a pool of primary transfectants. The proteome of each stably transfected cell line was analyzed at mid-exponential growth phase by two-dimensional gel electrophoresis (2D-PAGE) and individual protein spot volume data derived from digitized gel images were compared statistically. To identify changes in protein abundance associated with qMab clatasets were screened for proteins that exhibited either a linear correlation with cell line qMab or a conserved change in abundance specific only to the cell line with highest qMab. Several proteins with altered abundance were identified by mass spectrometry. Proteins exhibiting a significant increase in abundance with increasing qMab included molecular chaperones known to interact directly with nascent immunoglobulins during their folding and assembly (e.g., BiP, endoplasmin, protein disulfide isomerase). 2D-PAGE analysis showed that in all cell lines Mab light chain was more abundant than heavy chain, indicating that this is a likely prerequisite for efficient Mab production. In summary, these data reveal both the adaptive responses and molecular mechanisms enabling mammalian cells in culture to achieve high-level recombinant monoclonal antibody production. (C) 2004 Wiley Periodicals, Inc.