地震作用下大型升船机结构的时变动力可靠度

利用三维有限元方法对三峡升船机塔柱结构的动力学特性及随机地震响应进行了计算分析,结果表明塔柱结构柔度较大,其项部节点随机地震位移响应为中宽带过程.在此基础上,采用首次超越破坏机制,以塔柱结构顶部典型位置的位移限值为可靠度界限,对设计地震烈度下升船机塔柱结构的时变动力可靠度进行了计算分析,得到了塔柱结构设计基准期内的时变动力可靠度,并讨论了可靠度界限值的随机性对结构抗震时变可靠度计算结果的影响,建议升船机结构抗震可靠度计算模型采用Markov过程假定.该文可为升船机结构设计及安全运行提供必要的参考.

Time and space-resolved measurement of a gas-puff laser-plasma x-ray source

The dynamic interaction processes between a nano-second laser pulse and a gas-puff target, such as those of plasma formation, laser heating, and x-ray emission, have been investigated quantitatively. Time and space-resolved x-ray and optical measurement techniques were used in order to investigate time-resolved laser absorption and subsequent x-ray generation. Efficient absorption of the incident laser energy into the gas-puff target of 17%, 12%, 38%, and 91% for neon, argon, krypton, and xenon, respectively, was shown experimentally. It was found that the laser absorption starts and, simultaneously, soft x-ray emission occurs. The soft x-ray lasts much longer than the laser pulse due to the recombination. Temporal evolution of the soft x-ray emission region was analyzed by comparing the experimental results to the results of the model calculation, in which the laser light propagation through a gas-puff plasma was taken into account. (C) 2003 American Institute of Physics.

Photoelectron angular distributions of molecules in bichromatic laser fields of circular polarization

Photoelectron angular distributions (PADs) from above-threshold ionization of O-2 and N-2 molecules irradiated by a bichromatic laser field of circular polarization are Studied. The bichromatic laser field is specially modulated such that it can be used to mimic a sequence of one-cycle laser pulses. The PADs are greatly affected by the molecular alignment, the symmetry of the initial electronic distribution, and the carrier-envelope phase of the laser pulses. Generally, the PADs do not show any symmetry, and become symmetric about an axis only when the symmetric axis of laser field coincides with the symmetric axis of molecules. This study shows that the few-cycle laser pulses call be used to steer the photoelectrons and perform the selective ionization of molecules. (C) 2008 Elsevier B.V. All rights reserved.

The status of Arctic charr, Salvelinus alpinus (L.), in southern Scotland: a cause for concern

The objective of this article is to review the populations of Arctic charr in the south of Scotland which have become locally extinct, and the reasons for their demise. In the British Isles, the Arctic charr in individual lakes have been isolated from each other for thousands of years and have developed a variety of phenotypic characteristics which are probably genetically based. About 200 populations of Arctic charr have been recorded from different parts of the British Isles: approximately 12 in England, 50 in Ireland, 175 in Scotland and four in Wales. The threats to charr from acidification, afforestation, engineering schemes, angling and fish farming are assessed, and the establishment of new populations is proposed as a method of replacing extinct stocks or providing an additional safeguard for valuable stocks in threatened waters.

Effects of a flash-flood on channel morphology and some insects of a small stony stream in the Peak District, Derbyshire

In this paper, some observations are made following a flash-flood that occurred in Stake Clough, a small tributary of the River Goyt, during the evening of 6 August 1996. The site was visited eight times between 8 August - 30 October 1996 to take samples and make observations on the stream. The flood scoured the bed of Stake Clough but more significantly, caused it to change course along the middle part of the floodplain. Initially after the flood, the numbers of insects in all stretches of the stream channel were low (100-200 m super(2)), but then gradually rose to population densities approaching ten times this figure. The benthos was dominated by the Chironomidae and also leuctrid stoneflies (Leuctra nigra, L. hippopus and L. inermis). On 8th August 1996, 12 mesh bags, each containing oak leaves, were placed in the stream and collected after 24 hours. These were also dominated by chironomids, and contained relatively high numbers of the caddis, Potamophylax cingulatus.

A new method of measuring the waveguide dispersion factor and the thermo-optic coefficient of long-period fiber gratings

Based on the Mach-Zehnder effect between the core mode and the cladding modes, the interference fringes are formed by a pair of cascaded long-period fiber gratings (CLPFGs). Theoretical analyses show that the spectral spacing and the wavelength of these fringes are functions of the waveguide dispersion factor gamma, which is a characterizing parameter to LPFG and with theoretical and applicational significance. By measuring the characteristics of the transmission spectra of CLPFGs, the absolute value of gamma can be obtained. At the same time, the thermo-optic coefficient of effective refractive index difference between core and cladding modes, p, can also be obtained by measured the temperature sensitivity of these fringes. In the experiments, \gamma\ and mu were measured by this method to be 0.874 and 4.08 x 10(-5) degreesC(-1), respectively, for LPFGs with period of 450 mum and with a HE14 resonant peak at 1554 nm. (C) 2004 Elsevier B.V. All rights reserved.

La flexiguridad como clave de la política de empleo en la UE: entre la competitividad, la inclusión social y el respeto a los derechos sociales

Esta publicación obtuvo el "IX Premio de Investigación Fracisco Javier de Landaburu Universitas 2010"

Molecular Antennas and Photoactive Nanomaterials based on Energy Transfer Processes

110 p.

Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy

Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be elevated in severe autism, leading to the 'anabolic hypothesis' of its etiology. Here we performed a focused microarray analysis of genes belonging to NOTCH and WNT signaling cascades, as well as genes related to AD and apoptosis pathways in cerebellar samples from autistic individuals, to provide further evidence for pathological relevance of these cascades for autism. By using the limma package from R and false discovery rate, we demonstrated that 31% (116 out of 374) of the genes belonging to these pathways displayed significant changes in expression (corrected P-values <0.05), with mitochondria- related genes being the most downregulated. We also found upregulation of GRIN1, the channel-forming subunit of NMDA glutamate receptors, and MAP3K1, known activator of the JNK and ERK pathways with anti-apoptotic effect. Expression of PSEN2 (presinilin 2) and APBB1 (or F65) were significantly lower when compared with control samples. Based on these results, we propose a model of NMDA glutamate receptor-mediated ERK activation of alpha-secretase activity and mitochondrial adaptation to apoptosis that may explain the early brain overgrowth and disruption of synaptic plasticity and connectome in autism. Finally, systems pharmacology analyses of the model that integrates all these genes together (NOWADA) highlighted magnesium (Mg2+) and rapamycin as most efficient drugs to target this network model in silico. Their potential therapeutic application, in the context of autism, is therefore discussed.