Hugo von St. Victor und die theologischen Richtungen seiner Zeit /

Includes bibliographical references.

The management improvement initiative : progress report to the General Assembly, Public Act 97-0558 /

On August 25, 2011, Governor Pat Quinn signed House Bill 1488 into law, now Public Act 97-0558 (The Act). The Act specifically directs a Management Improvement Initiative Committee (The Committee) to implement recommendations outlined in the January 2011 report to the General Assembly as required under Public Act 96-1141. The Act directs the group, formed under the auspices of Public Act 96-1141, to continue their work based on categories of recommendations. Each recommendation area has the common goal of reviewing providers from redundant monitoring, auditing, and reporting requirements. Implementing the recommendations of the Act will result in efficiency in business process for our providers, reinvestment of dollars saved from inefficient or unrealized administrative costs, and ultimately foster a network of sustainable human services providers in Illinois while increasing the level of direct service by the State agencies, contracted providers, and communities, who are all facing current economic pressures in the fiscal crisis.

Shou cheng lu : 4 juan /

Block print.

Die Psychologie des Hugo von St. Viktor. Ein Beitrag zur Geschichte der Psychologie in der Frühscholastik,

Bibliographical footnotes.

Bulletin.

Ceased publication with no 1546, June 1971?

Chronicles of the reigns of Stephen, Henry II., and Richard I.

Vol. 4 has imprint: London, Printed for H. M. Stationery off., by Eyre and Spottiswoode.

PROVOCAÇÕES PARA UMA EDUCAÇÃO SENSÍVEL: O OLHAR DO GESTOR PARA O NÃO DITO

Ser sujeito e objeto de seu fazer de pesquisador/educador. Essa é a proposta de pesquisa realizada por este trabalho, por meio da narrativa de história de vida e da implicação do olhar do educador, para compreender a importância da sensibilidade na constituição do sujeito-autor, em uma gestão sensível e democrática. No processo de formação de cidadãos-autores, é preciso considerar a subjetividade como fundamental na formação do sujeito-autor. A relação de ensino-aprendizagem, relação entre sujeitos, para que seja significativa e democrática deve considerar que, em parte, essa relação se dá na intersubjetividade. E como forma de conhecermos nossa sensibilidade, a experiência em uma linguagem artística, diante das funções pedagógicas que a arte possui, surge como uma possibilidade de construção de sentido.(AU)

Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1)

Multidrug resistance protein MRP1 mediates the ATP-dependent efflux of many chemotherapeutic agents and organic anions. MRP1 has two nucleotide binding sites (NBSs) and three membrane spanning domains (MSDs) containing 17 transmembrane helices linked by extracellular and cytoplasmic loops (CL). Homology models suggest that CL7 (amino acids 1141-1195) is in a position where it could participate in signaling between the MSDs and NBSs during the transport process. We have individually replaced eight charged residues in CL7 with Ala, and in some cases, an amino acid with the same charge, and then investigated the effects on MRP1 expression, transport activity, and nucleotide and substrate interactions. A triple mutant in which Glu(1169), Glu(1170), and Glu(1172) were all replaced with Ala was also examined. The properties of R1173A and E1184A were comparable with those of wild-type MRP1, whereas the remaining mutants were either poorly expressed (R1166A, D1183A) or exhibited reduced transport of one or more organic anions (E1144A, D1179A, K1181A, (1169)AAQA). Same charge mutant D1183E was also not expressed, whereas expression and activity of R1166K were similar to wild-type MRP1. The moderate substrate-selective changes in transport activity displayed by mutants E1144A, D1179A, K1181A, and (1169)AAQA were accompanied by changes in orthovanadate-induced trapping of [alpha-(32)P]azidoADP by NBS2 indicating changes in ATP hydrolysis or release of ADP. In the case of E1144A, estradiol glucuronide no longer inhibited trapping of azidoADP. Together, our results demonstrate the extreme sensitivity of CL7 to mutation, consistent with its critical and complex dual role in both the proper folding and transport activity of MRP1.

Formulation design considerations for oral vaccines

Whilst oral vaccination is a potentially preferred route in terms of patient adherence and mass vaccination, the ability to formulate effective oral vaccines remains a challenge. The primary barrier to oral vaccination is effective delivery of the vaccine through the GI tract owing to the many obstacles it presents, including low pH, enzyme degradation and bile-salt solubilization, which can result in breakdown/deactivation of a vaccine. For effective immune responses after oral administration, particulates need to be taken up bythe M cells however, these are few in number. To enhance M-cell uptake, particle characteristics can be optimized with particle size, surface charge, targeting groups and bioadhesive properties all being considerations. Yet improved uptake may not translate into enhanced immune responses and formulating particulates with inherent adjuvant properties can offer advantages. Within this article, we establish the options available for consideration when building effective oral particulate vaccines.

The primacy of data?

Purpose – The purpose of this editorial is to stimulate debate and discussion amongst marketing scholarship regarding the implications for scientific research of increasingly large amounts of data and sophisticated data analytic techniques. Design/methodology/approach – The authors respond to a recent editorial in WIRED magazine which heralds the demise of the scientific method in the face of the vast data sets now available. Findings – The authors propose that more data makes theory more important, not less. They differentiate between raw prediction and scientific knowledge – which is aimed at explanation. Research limitations/implications – These thoughts are preliminary and intended to spark thinking and debate, not represent editorial policy. Due to space constraints, the coverage of many issues is necessarily brief. Practical implications – Marketing researchers should find these thoughts at the very least stimulating, and may wish to investigate these issues further. Originality/value – This piece should provide some interesting food for thought for marketing researchers.

Transversal-load sensor by using local pressure on a chirped fiber bragg grating

A transversal-load sensor based on the local pressure-induced refractive index change in a chirped fiber Bragg grating (CFBG) is proposed. The local pressure induced refractive index change in the touch point can generate a main transmission peak and several subpeaks on the long wavelength side of the reflection band of the CFBG. The difference of the wavelength shifts for the main transmission peak and the first subpeak is used to measure transversal-load with temperature compensation capability.